Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury.
about
Progranulin directly binds to the CRD2 and CRD3 of TNFR extracellular domainsMechanisms of granulin deficiency: lessons from cellular and animal modelsTherapeutic and diagnostic challenges for frontotemporal dementiaPotential roles of microglial cell progranulin in HIV-associated CNS pathologies and neurocognitive impairmentProgranulin: at the interface of neurodegenerative and metabolic diseasesGranulin knock out zebrafish lack frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis pathologyFunction and Dysfunction of Microglia during Brain Development: Consequences for Synapses and Neural CircuitsProgranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models.Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation.Withania somnifera Reverses Transactive Response DNA Binding Protein 43 Proteinopathy in a Mouse Model of Amyotrophic Lateral Sclerosis/Frontotemporal Lobar Degeneration.White matter hyperintensities are seen only in GRN mutation carriers in the GENFI cohort.Evidence of the innate antiviral and neuroprotective properties of progranulin.Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia.Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis.Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLDSystemic inflammation and the brain: novel roles of genetic, molecular, and environmental cues as drivers of neurodegeneration.Progranulin gene delivery protects dopaminergic neurons in a mouse model of Parkinson's disease.Three TNFR-binding domains of PGRN act independently in inhibition of TNF-alpha binding and activity.Effects of Exercise on Progranulin Levels and Gliosis in Progranulin-Insufficient MiceProgranulin and Its Related MicroRNAs after Status Epilepticus: Possible Mechanisms of Neuroprotection.Neurotrophic effects of progranulin in vivo in reversing motor neuron defects caused by over or under expression of TDP-43 or FUS.Progranulin Reduced Neuronal Cell Death by Activation of Sortilin 1 Signaling Pathways After Subarachnoid Hemorrhage in Rats.Progranulin deficiency leads to severe inflammation, lung injury and cell death in a mouse model of endotoxic shock.Asymmetric pathology in primary progressive aphasia with progranulin mutations and TDP inclusions.Secreted progranulin is a homodimer and is not a component of high density lipoproteins (HDL)Reducing inflammation and rescuing FTD-related behavioral deficits in progranulin-deficient mice with α7 nicotinic acetylcholine receptor agonistsProgranulin knockout accelerates intervertebral disc degeneration in aging miceProgranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells.The role of the innate immune system in Alzheimer's disease and frontotemporal lobar degeneration: an eye on microglia.Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice.Progranulin deficiency promotes post-ischemic blood-brain barrier disruptionGlucose deprivation regulates the progranulin-sortilin axis in PC12 cells.Immune-mediated mechanisms in the pathoprogression of amyotrophic lateral sclerosis.Innate immune activation in neurodegenerative disease.The role of neuroinflammation in dementias.The Role of TDP-43 in Alzheimer's Disease.Progranulin, lysosomal regulation and neurodegenerative disease.The Receptor-interacting Serine/Threonine Protein Kinase 1 (RIPK1) Regulates Progranulin Levels.Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo.Prosaposin is a regulator of progranulin levels and oligomerization.
P2860
Q24337327-B9B3F8AE-3F1F-4940-9C50-C01CCC6CFED2Q26824221-1B53FE33-2AFA-4F00-8182-7ABA46B5CAEAQ26998919-E7227177-BA54-4A0F-A405-6D3CC5189E36Q27011876-0720E56F-1706-40C5-AAE5-2ED175CCF6F3Q27024421-3576BBAF-4A69-4B9E-AA85-856F8A29B5DBQ28544656-C2221232-DAEF-4434-978D-3DF57E05FBEEQ30355850-4106B8BB-9609-4CBD-B0D4-B784AE222CA7Q30592224-D2B327AB-CCCC-4B10-BE44-F6A1DCD52367Q30754508-56A3FD59-747D-48E3-9F89-C58EC89FD5E5Q33586011-9D8EF2EA-D356-47C9-BFAE-BBF70FA8F92FQ33676267-1B1EAD8F-4EBC-4531-AED6-C78CE1226F5CQ33690042-1E2B2E97-12B4-48E7-9780-F2D84C0C8A10Q33719360-59D0560E-06C7-45B8-A713-CAFAB5FB0D93Q33926457-C0B2628A-3B1A-43A3-B511-7C6D8AF08833Q34230498-C0936A6D-2B50-48A1-BAE4-F82642B4BC23Q34463760-391B852E-B69C-4BDD-A36E-FE6603CDC397Q35164339-AA6CD73E-7B71-41DF-B9CC-1387A9004316Q35541825-BEA52BF0-6512-4E28-8A76-E697F4BA50F5Q36036743-FC3D5129-3743-4EEB-BA66-BCF8AE2EE8CAQ36293051-7A4BE0E8-4573-4ED2-B6E3-F0BEBA6A1941Q36328461-E377C407-B3D4-4643-B4CD-80ABA5E0EFD3Q36570798-C8D73517-C9DE-430A-9659-63725B1799D8Q36595272-ECB2C0D8-717B-4F8F-AA76-2312C67483D9Q36603819-DCC86D46-616A-492A-877E-B6FA9BC1C87FQ36708664-17A20384-A3FB-4A73-9D48-BA36A1E0FD00Q36877434-57034B82-D453-428C-98D3-5CE75D2F2783Q36972672-0316D895-2127-414C-88CA-2B988E015383Q36999042-B12AA00B-CAAE-4E6E-94EF-A237864749CFQ37067641-588FDDE1-DB5A-4DE1-8431-7BA5F4445E4FQ37087755-DC3B15BA-854E-4174-9E7A-22A4896A92C7Q37381816-649C8A1B-B3AF-40FF-B01F-062FACEED9D7Q37625611-3AC3C127-868A-4443-9E0D-3DAE420A5EE7Q38123758-DC076AA1-B521-4B4C-AAC0-2F592A415BF3Q38223011-029CD5C7-78B2-418A-B39E-95CE43F7AD47Q38365247-AD8F7189-F212-43D3-993D-8B726719B2ECQ38529627-B9468176-65D6-4B80-9B0D-0BB20F46D3C7Q38691811-D7F039F8-F5B1-4EED-B1F2-C08443FCF179Q38722210-14C82627-ED58-488C-9852-C62656754369Q38814424-6D304C31-CA02-43BF-AD74-026BD6DFFDEAQ38847140-C1E5C636-D5E7-4BF6-870C-2B01B404E734
P2860
Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Progranulin deficiency promote ...... ollowing toxin-induced injury.
@ast
Progranulin deficiency promote ...... ollowing toxin-induced injury.
@en
type
label
Progranulin deficiency promote ...... ollowing toxin-induced injury.
@ast
Progranulin deficiency promote ...... ollowing toxin-induced injury.
@en
prefLabel
Progranulin deficiency promote ...... ollowing toxin-induced injury.
@ast
Progranulin deficiency promote ...... ollowing toxin-induced injury.
@en
P2093
P2860
P356
P1476
Progranulin deficiency promote ...... ollowing toxin-induced injury.
@en
P2093
Jiasheng Zhang
Lauren Herl Martens
Robert V Farese
Sami J Barmada
Sang-Won Min
Sherry Kamiya
Steven Finkbeiner
P2860
P304
P356
10.1172/JCI63113
P407
P577
2012-10-08T00:00:00Z