Dimethyl fumarate and monoethyl fumarate exhibit differential effects on KEAP1, NRF2 activation, and glutathione depletion in vitro. - Wikidata - awgldk - TriplyDB

Dimethyl fumarate and monoethyl fumarate exhibit differential effects on KEAP1, NRF2 activation, and glutathione depletion in vitro.

Dimethyl fumarate and monoethyl fumarate exhibit differential effects on KEAP1, NRF2 activation, and glutathione depletion in vitro.

http://www.wikidata.org/entity/Q35582048

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Dimethyl fumarate in multiple sclerosis: latest developments, evidence and place in therapy Oral Multiple Sclerosis Drugs Inhibit the In vitro Growth of Epsilon Toxin Producing Gut Bacterium, Clostridium perfringens Fumarate treatment in progressive forms of multiple sclerosis: first results of a single-center observational study Dimethyl fumarate modulates antioxidant and lipid metabolism in oligodendrocytes.Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2.Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease.Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson's Disease Dimethyl Fumarate: A Review in Relapsing-Remitting MS.Antioxidant and Anti-Inflammatory Activities of a Natural Compound, Shizukahenriol, through Nrf2 Activation.The NRF2 transcriptional target, OSGIN1, contributes to monomethyl fumarate-mediated cytoprotection in human astrocytes.Progressive multifocal leukoencephalopathy in patients treated with fumaric acid esters: a review of 19 cases.The Neuroprotective Effect of Dimethyl Fumarate in an MPTP-Mouse Model of Parkinson's Disease: Involvement of Reactive Oxygen Species/Nuclear Factor-κB/Nuclear Transcription Factor Related to NF-E2.Dimethyl fumarate blocks pro-inflammatory cytokine production via inhibition of TLR induced M1 and K63 ubiquitin chain formation.Effects of fumarates on inflammatory human astrocyte responses and oligodendrocyte differentiation.Dimethyl fumarate mediates Nrf2-dependent mitochondrial biogenesis in mice and humans.Recent advances in understanding NRF2 as a druggable target: development of pro-electrophilic and non-covalent NRF2 activators to overcome systemic side effects of electrophilic drugs like dimethyl fumarate.Dimethyl fumarate treatment after traumatic brain injury prevents depletion of antioxidative brain glutathione and confers neuroprotection.Homocysteine Induces Glial Reactivity in Adult Rat Astrocyte Cultures.Effect of dimethyl fumarate on renal disease progression in a genetic ortholog of nephronophthisis.The Role of Astrocytes in Multiple Sclerosis.Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.Dimethyl fumarate (DMF) vs. monoethyl fumarate (MEF) salts for the treatment of plaque psoriasis: a review of clinical data.Efficacy and safety of LAS41008 (dimethyl fumarate) in adults with moderate-to-severe chronic plaque psoriasis: a randomized, double-blind, Fumaderm® - and placebo-controlled trial (BRIDGE).Dimethyl fumarate is coming of age Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases

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P2860

Dimethyl fumarate and monoethyl fumarate exhibit differential effects on KEAP1, NRF2 activation, and glutathione depletion in vitro.

http://www.wikidata.org/entity/Q35582048

description

2015 nî lūn-bûn

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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2015年论文

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2015年论文

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name

Dimethyl fumarate and monoethy ...... lutathione depletion in vitro.

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Dimethyl fumarate and monoethy ...... lutathione depletion in vitro.

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type

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Dimethyl fumarate and monoethy ...... lutathione depletion in vitro.

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Dimethyl fumarate and monoethy ...... lutathione depletion in vitro.

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Dimethyl fumarate and monoethy ...... lutathione depletion in vitro.

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Dimethyl fumarate and monoethy ...... lutathione depletion in vitro.

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JOURNAL.PONE.0120254

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Dimethyl fumarate and monoethy ...... lutathione depletion in vitro.

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P2093

Benbo Gao

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Bing Li

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Kenneth J Rhodes

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Maria F Matos

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Melanie S Brennan

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Peter Juhasz

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Xiaoping Hronowski

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P2860

Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity

Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1

Multiple sclerosis

Regulatory mechanisms controlling gene expression mediated by the antioxidant response element

Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress

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Robert Scannevin

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2015-03-20T00:00:00Z

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