CDC45 and DPB11 are required for processive DNA replication and resistance to DNA topoisomerase I-mediated DNA damage.
about
Dpb11 controls the association between DNA polymerases alpha and epsilon and the autonomously replicating sequence region of budding yeastDNA synthesis at individual replication forks requires the essential initiation factor Cdc45pA S-adenosylmethionine methyltransferase-like domain within the essential, Fe-S-containing yeast protein Dre2A newly identified essential complex, Dre2-Tah18, controls mitochondria integrity and cell death after oxidative stress in yeast.TOR signaling is a determinant of cell survival in response to DNA damage.The role of DNA double-strand breaks in spontaneous homologous recombination in S. cerevisiaeCentral role for cdc45 in establishing an initiation complex of DNA replication in Xenopus egg extractsIrinotecan pharmacogenomicsMutations in SID2, a novel gene in Saccharomyces cerevisiae, cause synthetic lethality with sic1 deletion and may cause a defect during S phasePharmacogenetics research on chemotherapy resistance in colorectal cancer over the last 20 yearsDistinct functional domains of Ubc9 dictate cell survival and resistance to genotoxic stressSrs2 overexpression reveals a helicase-independent role at replication forks that requires diverse cell functionsYeast recombination pathways triggered by topoisomerase II-mediated DNA breaks.Pharmacogenetics of irinotecan toxicity.Repair of topoisomerase I-mediated DNA damage.Structure of human Cdc45 and implications for CMG helicase functionA role for the p53 tumour suppressor in regulating the balance between homologous recombination and non-homologous end joining.Proteasome-dependent processing of topoisomerase I-DNA adducts into DNA double strand breaks at arrested replication forks.Active site mutations in DNA topoisomerase I distinguish the cytotoxic activities of camptothecin and the indolocarbazole, rebeccamycin.A mutation in human topoisomerase II alpha whose expression is lethal in DNA repair-deficient yeast cells.Schizosaccharomyces pombe cells lacking the amino-terminal catalytic domains of DNA polymerase epsilon are viable but require the DNA damage checkpoint control.Chromosome integrity in Saccharomyces cerevisiae: the interplay of DNA replication initiation factors, elongation factors, and origins.Chromosomal fragmentation is the major consequence of the rdgB defect in Escherichia coli.Pathways for repair of topoisomerase I covalent complexes in Saccharomyces cerevisiae.Kinetic studies of human tyrosyl-DNA phosphodiesterase, an enzyme in the topoisomerase I DNA repair pathway.The deubiquitinating enzyme Doa4p protects cells from DNA topoisomerase I poisons.Substitution of conserved residues within the active site alters the cleavage religation equilibrium of DNA topoisomerase I.Defects in SUMO (small ubiquitin-related modifier) conjugation and deconjugation alter cell sensitivity to DNA topoisomerase I-induced DNA damage.Substitutions of Asn-726 in the active site of yeast DNA topoisomerase I define novel mechanisms of stabilizing the covalent enzyme-DNA intermediate.
P2860
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P2860
CDC45 and DPB11 are required for processive DNA replication and resistance to DNA topoisomerase I-mediated DNA damage.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
CDC45 and DPB11 are required f ...... omerase I-mediated DNA damage.
@ast
CDC45 and DPB11 are required f ...... omerase I-mediated DNA damage.
@en
type
label
CDC45 and DPB11 are required f ...... omerase I-mediated DNA damage.
@ast
CDC45 and DPB11 are required f ...... omerase I-mediated DNA damage.
@en
prefLabel
CDC45 and DPB11 are required f ...... omerase I-mediated DNA damage.
@ast
CDC45 and DPB11 are required f ...... omerase I-mediated DNA damage.
@en
P2093
P2860
P356
P1476
CDC45 and DPB11 are required f ...... somerase I-mediated DNA damage
@en
P2093
M A Bjornsti
M Sugawara
P2860
P304
11440-11445
P356
10.1073/PNAS.96.20.11440
P407
P577
1999-09-01T00:00:00Z