Substitutions of Asn-726 in the active site of yeast DNA topoisomerase I define novel mechanisms of stabilizing the covalent enzyme-DNA intermediate.
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Inhibition of topoisomerase I cleavage activity by thiol-reactive compounds: importance of vicinal cysteines 504 and 505Structural impact of the leukemia drug 1-beta-D-arabinofuranosylcytosine (Ara-C) on the covalent human topoisomerase I-DNA complexLocking the DNA topoisomerase I protein clamp inhibits DNA rotation and induces cell lethality.Contributions of histone H3 nucleosome core surface mutations to chromatin structures, silencing and DNA repair.Mapping topoisomerase sites in mitochondrial DNA with a poisonous mitochondrial topoisomerase I (Top1mt).Structure and hydration of the DNA-human topoisomerase I covalent complex.Tyrosyl-DNA phosphodiesterase I catalytic mutants reveal an alternative nucleophile that can catalyze substrate cleavageDNA topoisomerase I domain interactions impact enzyme activity and sensitivity to camptothecin.Contribution of the serine 129 of histone H2A to chromatin structure.Mutations in topoisomerase I as a self-resistance mechanism coevolved with the production of the anticancer alkaloid camptothecin in plantsCharacterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutationsThr729 in human topoisomerase I modulates anti-cancer drug resistance by altering protein domain communications as suggested by molecular dynamics simulations.Mutation of Gly721 alters DNA topoisomerase I active site architecture and sensitivity to camptothecin.Similar structural basis for membrane localization and protein priming by an RNA-dependent RNA polymerase.Active site mutations in DNA topoisomerase I distinguish the cytotoxic activities of camptothecin and the indolocarbazole, rebeccamycin.A mutation in human topoisomerase II alpha whose expression is lethal in DNA repair-deficient yeast cells.Role of the linker domain and the 203-214 N-terminal residues in the human topoisomerase I DNA complex dynamics.A single mutation in the 729 residue modulates human DNA topoisomerase IB DNA binding and drug resistance.The deubiquitinating enzyme Doa4p protects cells from DNA topoisomerase I poisons.Substitution of conserved residues within the active site alters the cleavage religation equilibrium of DNA topoisomerase I.Defects in SUMO (small ubiquitin-related modifier) conjugation and deconjugation alter cell sensitivity to DNA topoisomerase I-induced DNA damage.
P2860
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P2860
Substitutions of Asn-726 in the active site of yeast DNA topoisomerase I define novel mechanisms of stabilizing the covalent enzyme-DNA intermediate.
description
2000 nî lūn-bûn
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name
Substitutions of Asn-726 in th ...... alent enzyme-DNA intermediate.
@en
Substitutions of Asn-726 in th ...... alent enzyme-DNA intermediate.
@nl
type
label
Substitutions of Asn-726 in th ...... alent enzyme-DNA intermediate.
@en
Substitutions of Asn-726 in th ...... alent enzyme-DNA intermediate.
@nl
prefLabel
Substitutions of Asn-726 in th ...... alent enzyme-DNA intermediate.
@en
Substitutions of Asn-726 in th ...... alent enzyme-DNA intermediate.
@nl
P2093
P2860
P356
P1476
Substitutions of Asn-726 in th ...... alent enzyme-DNA intermediate.
@en
P2093
P2860
P304
15246-15253
P356
10.1074/JBC.275.20.15246
P407
P577
2000-05-01T00:00:00Z