A single autoimmune T cell receptor recognizes more than a million different peptides. - Wikidata - awgldk - TriplyDB

A single autoimmune T cell receptor recognizes more than a million different peptides.

A single autoimmune T cell receptor recognizes more than a million different peptides.

http://www.wikidata.org/entity/Q35668865

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The Unspecific Side of Acquired Immunity Against Infectious Disease: Causes and Consequences Functional Heterogeneity in CD4(+) T Cell Responses Against a Bacterial Pathogen Lower Affinity T Cells are Critical Components and Active Participants of the Immune Response Systemic Lupus Erythematosus: Molecular Mimicry between Anti-dsDNA CDR3 Idiotype, Microbial and Self Peptides-As Antigens for Th Cells The role of the gut microbiota in the pathogenesis of antiphospholipid syndrome TLR cross-talk confers specificity to innate immunity Antigen-Specific T-Cell Activation Independently of the MHC: Chimeric Antigen Receptor-Redirected T Cells T-cell Receptor-optimized Peptide Skewing of the T-cell Repertoire Can Enhance Antigen Targeting Peptide length determines the outcome of TCR/peptide-MHCI engagement Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes.T-cell Receptor Specificity Maintained by Altered Thermodynamics Increased peptide contacts govern high affinity binding of a modified TCR whilst maintaining a native pMHC docking mode T-cell Receptor (TCR)-Peptide Specificity Overrides Affinity-enhancing TCR-Major Histocompatibility Complex Interactions Deconstructing the Peptide-MHC Specificity of T Cell Recognition Lack of heterologous cross-reactivity towards HLA-A*02:01 restricted viral epitopes is underpinned by distinct αβT cell receptor signatures T-cell receptor gene therapy--ready to go viral?Selective antigen-specific CD4(+) T-cell, but not CD8(+) T- or B-cell, tolerance corrupts cancer immunotherapy.TAPBPR alters MHC class I peptide presentation by functioning as a peptide exchange catalyst Generation of individual diversity: a too neglected fundamental property of adaptive immune system.Sequence and Structural Analyses Reveal Distinct and Highly Diverse Human CD8+ TCR Repertoires to Immunodominant Viral Antigens Somatic mutations in clonally expanded cytotoxic T lymphocytes in patients with newly diagnosed rheumatoid arthritis.Compensatory mechanisms allow undersized anchor-deficient class I MHC ligands to mediate pathogenic autoreactive T cell responses Revisiting thymic positive selection and the mature T cell repertoire for antigen.Different affinity windows for virus and cancer-specific T-cell receptors: implications for therapeutic strategies Major histocompatibility complex genomics and human disease.Specific increase in potency via structure-based design of a TCR.Diversity-oriented approaches for interrogating T-cell receptor repertoire, ligand recognition, and function Peptide library-based evaluation of T-cell receptor breadth detects defects in global and regulatory activation in human immunologic diseases.Antibody stabilization of peptide-MHC multimers reveals functional T cells bearing extremely low-affinity TCRs CD8(+) T cell cross-reactivity profiles and HIV-1 immune escape towards an HLA-B35-restricted immunodominant Nef epitope.Improving antigenic peptide vaccines for cancer immunotherapy using a dominant tumor-specific T cell receptor.Quantum chemical calculations predict biological function: the case of T cell receptor interaction with a peptide/MHC class I.Intramolecular polyspecificity in CD4 T-cell recognition of Ad-restricted epitopes of proteoglycan aggrecan.Specific roles of each TCR hemichain in generating functional chain-centric TCR.Clonotypically similar hybrid αβ T cell receptors can exhibit markedly different surface expression, antigen specificity and cross-reactivity.Longitudinal analysis of peripheral blood T cell receptor diversity in patients with systemic lupus erythematosus by next-generation sequencing Identification of a naturally processed HLA-Cw7-binding peptide that cross-reacts with HLA-A24-restricted ovarian cancer-specific CTLs.Insulitis and characterisation of infiltrating T cells in surgical pancreatic tail resections from patients at onset of type 1 diabetes.Analysis of the functional WT1-specific T-cell repertoire in healthy donors reveals a discrepancy between CD4(+) and CD8(+) memory formation.Autopolyreactivity Confers a Holistic Role in the Immune System.

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A single autoimmune T cell receptor recognizes more than a million different peptides.

http://www.wikidata.org/entity/Q35668865

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2011 nî lūn-bûn

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2011年の論文

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2011年论文

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2011年论文

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A single autoimmune T cell receptor recognizes more than a million different peptides.

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A single autoimmune T cell receptor recognizes more than a million different peptides.

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A single autoimmune T cell receptor recognizes more than a million different peptides.

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A single autoimmune T cell receptor recognizes more than a million different peptides.

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A single autoimmune T cell receptor recognizes more than a million different peptides.

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A single autoimmune T cell receptor recognizes more than a million different peptides.

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JBC.M111.289488

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Journal of Biological Chemistry

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A single autoimmune T cell receptor recognizes more than a million different peptides.

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P2093

Anna Skowera

http://www.w3.org/2001/XMLSchema#string

Garry Dolton

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Hugo A van den Berg

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Julia Ekeruche-Makinde

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Linda Wooldridge

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Mai Ping Tan

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Mathew Clement

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Sian Llewellyn-Lacey

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P2860

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

Mimotopes for alloreactive and conventional T cells in a peptide-MHC display library

Crystal structure of a T cell receptor bound to an allogeneic MHC molecule

Crossreactive T Cells Spotlight the Germline Rules for αβ T Cell-Receptor Interactions with MHC Molecules

T cell allorecognition via molecular mimicry

Fidelity of T cell activation through multistep T cell receptor zeta phosphorylation

Quantitating T cell cross-reactivity for unrelated peptide antigens

How TCRs bind MHCs, peptides, and coreceptors

Antigen arrays in T cell immunology.

Specificity and degeneracy of T cells.

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Andrew K Sewell

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