Mad3p, a pseudosubstrate inhibitor of APCCdc20 in the spindle assembly checkpoint. - Wikidata - awgldk - TriplyDB

Mad3p, a pseudosubstrate inhibitor of APCCdc20 in the spindle assembly checkpoint.

Mad3p, a pseudosubstrate inhibitor of APCCdc20 in the spindle assembly checkpoint.

http://www.wikidata.org/entity/Q35677350

about

Reverse engineering of the spindle assembly checkpoint Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C-Cdc20 complex Probing the in vivo function of Mad1:C-Mad2 in the spindle assembly checkpoint BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis.The crystal structure of the N-terminal region of BUB1 provides insight into the mechanism of BUB1 recruitment to kinetochores Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis Modulation of cell cycle control during oocyte-to-embryo transitions Bub3-BubR1-dependent sequestration of Cdc20Fizzy at DNA breaks facilitates the correct segregation of broken chromosomes Bub1-mediated adaptation of the spindle checkpoint Structure and Substrate Recruitment of the Human Spindle Checkpoint Kinase Bub1 Defining the Molecular Basis of BubR1 Kinetochore Interactions and APC/C-CDC20 Inhibition Structural analysis of human Cdc20 supports multisite degron recognition by APC/C Structure of the mitotic checkpoint complex Insights into Degron Recognition by APC/C Coactivators from the Structure of an Acm1-Cdh1 Complex Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation The APC/C subunit Mnd2/Apc15 promotes Cdc20 autoubiquitination and spindle assembly checkpoint inactivation.Pseudosubstrate inhibition of the anaphase-promoting complex by Acm1: regulation by proteolysis and Cdc28 phosphorylation.Mechanisms of pseudosubstrate inhibition of the anaphase promoting complex by Acm1.Unique D box and KEN box sequences limit ubiquitination of Acm1 and promote pseudosubstrate inhibition of the anaphase-promoting complex Modulation of the mitotic regulatory network by APC-dependent destruction of the Cdh1 inhibitor Acm1.In-silico modeling of the mitotic spindle assembly checkpoint BubR1- and Polo-coated DNA tethers facilitate poleward segregation of acentric chromatids.Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex.Molecular basis of APC/C regulation by the spindle assembly checkpoint.Arabidopsis COPPER MODIFIED RESISTANCE1/PATRONUS1 is essential for growth adaptation to stress and required for mitotic onset control.The influence of catalysis on mad2 activation dynamics.Conditional targeting of MAD1 to kinetochores is sufficient to reactivate the spindle assembly checkpoint in metaphase.Using default constraints of the spindle assembly checkpoint to estimate the associated chemical rates.How chromosome mis-segregation leads to cancer: lessons from BubR1 mouse models Under arrest in mitosis: Cdc20 dies twice.The Cdc20-binding Phe box of the spindle checkpoint protein BubR1 maintains the mitotic checkpoint complex during mitosis.BUBR1 and closed MAD2 (C-MAD2) interact directly to assemble a functional mitotic checkpoint complex.Anaphase promoting complex-dependent degradation of transcriptional repressors Nrm1 and Yhp1 in Saccharomyces cerevisiae The biochemistry of mitosis Meiotic control of the APC/C: similarities & differences from mitosis.Defining pathways of spindle checkpoint silencing: functional redundancy between Cdc20 ubiquitination and p31(comet)Mutual regulation between the spindle checkpoint and APC/C.Closed MAD2 (C-MAD2) is selectively incorporated into the mitotic checkpoint complex (MCC)An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination Running on a treadmill: dynamic inhibition of APC/C by the spindle checkpoint.

P2860

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P2860

Mad3p, a pseudosubstrate inhibitor of APCCdc20 in the spindle assembly checkpoint.

http://www.wikidata.org/entity/Q35677350

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

@yue

2007年論文

@zh-hant

2007年論文

@zh-hk

2007年論文

@zh-mo

2007年論文

@zh-tw

2007年论文

@wuu

2007年论文

@zh

2007年论文

@zh-cn

name

Mad3p, a pseudosubstrate inhibitor of APCCdc20 in the spindle assembly checkpoint.

@ast

Mad3p, a pseudosubstrate inhibitor of APCCdc20 in the spindle assembly checkpoint.

@en

type

label

Mad3p, a pseudosubstrate inhibitor of APCCdc20 in the spindle assembly checkpoint.

@ast

Mad3p, a pseudosubstrate inhibitor of APCCdc20 in the spindle assembly checkpoint.

@en

prefLabel

Mad3p, a pseudosubstrate inhibitor of APCCdc20 in the spindle assembly checkpoint.

@ast

Mad3p, a pseudosubstrate inhibitor of APCCdc20 in the spindle assembly checkpoint.

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Genes & Development

P1476

Mad3p, a pseudosubstrate inhibitor of APCCdc20 in the spindle assembly checkpoint.

@en

P2093

Janet L Burton

http://www.w3.org/2001/XMLSchema#string

Mark J Solomon

http://www.w3.org/2001/XMLSchema#string

P2860

Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1

Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint

Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor

Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint

Bub3 interaction with Mad2, Mad3 and Cdc20 is mediated by WD40 repeats and does not require intact kinetochores

Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex

The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation

The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1

Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2

The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20

P304

655-667

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scholarly article

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10.1101/GAD.1511107

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6

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21

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2007-03-01T00:00:00Z

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6438861

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17369399

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1820940

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