Defining pathways of spindle checkpoint silencing: functional redundancy between Cdc20 ubiquitination and p31(comet)
about
Phosphorylation of EB2 by Aurora B and CDK1 ensures mitotic progression and genome stability.LOVTRAP: an optogenetic system for photoinduced protein dissociationCryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin LigationThe APC/C subunit Mnd2/Apc15 promotes Cdc20 autoubiquitination and spindle assembly checkpoint inactivation.Spatiotemporal regulation of the anaphase-promoting complex in mitosisThyroid hormone receptor interacting protein 13 (TRIP13) AAA-ATPase is a novel mitotic checkpoint-silencing proteinCohesion fatigue explains why pharmacological inhibition of the APC/C induces a spindle checkpoint-dependent mitotic arrestThe Cdc20-binding Phe box of the spindle checkpoint protein BubR1 maintains the mitotic checkpoint complex during mitosis.p31(comet) acts to ensure timely spindle checkpoint silencing subsequent to kinetochore attachmentMad2 and the APC/C compete for the same site on Cdc20 to ensure proper chromosome segregationPhosphorylation of Xenopus p31(comet) potentiates mitotic checkpoint exit.An E2 enzyme Ubc11 is required for ubiquitination of Slp1/Cdc20 and spindle checkpoint silencing in fission yeastMaking an effective switch at the kinetochore by phosphorylation and dephosphorylation.Roles of different pools of the mitotic checkpoint complex and the mechanisms of their disassembly.Monopolar spindle 1 (MPS1) kinase promotes production of closed MAD2 (C-MAD2) conformer and assembly of the mitotic checkpoint complexCoordinated regulation of p31(Comet) and Mad2 expression is required for cellular proliferationRegulatory mechanisms of kinetochore-microtubule interaction in mitosis.Connecting up and clearing out: how kinetochore attachment silences the spindle assembly checkpoint.Panta rhei: the APC/C at steady state.The Bub1-Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation.Phosphorylation regulates the p31Comet-mitotic arrest-deficient 2 (Mad2) interaction to promote spindle assembly checkpoint (SAC) activity.The mitotic checkpoint complex (MCC): looking back and forth after 15 years.APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex.Mitotic Checkpoint Regulators Control Insulin Signaling and Metabolic Homeostasis.Genome-wide siRNA screen reveals coupling between mitotic apoptosis and adaptationp31(comet) inactivates the chemically induced Mad2-dependent spindle assembly checkpoint and leads to resistance to anti-mitotic drugs.Catalytic assembly of the mitotic checkpoint inhibitor BubR1-Cdc20 by a Mad2-induced functional switch in Cdc20.Mechanistic insight into TRIP13-catalyzed Mad2 structural transition and spindle checkpoint silencing.HDAC2/3 binding and deacetylation of BubR1 initiates spindle assembly checkpoint silencing.Disruption of the anaphase-promoting complex confers resistance to TTK inhibitors in triple-negative breast cancer.Mechanism for remodelling of the cell cycle checkpoint protein MAD2 by the ATPase TRIP13
P2860
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P2860
Defining pathways of spindle checkpoint silencing: functional redundancy between Cdc20 ubiquitination and p31(comet)
description
2011 nî lūn-bûn
@nan
2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Defining pathways of spindle c ...... ubiquitination and p31(comet)
@ast
Defining pathways of spindle c ...... ubiquitination and p31(comet)
@en
type
label
Defining pathways of spindle c ...... ubiquitination and p31(comet)
@ast
Defining pathways of spindle c ...... ubiquitination and p31(comet)
@en
prefLabel
Defining pathways of spindle c ...... ubiquitination and p31(comet)
@ast
Defining pathways of spindle c ...... ubiquitination and p31(comet)
@en
P2093
P2860
P356
P1476
Defining pathways of spindle c ...... ubiquitination and p31(comet)
@en
P2093
Hongtao Yu
Luying Jia
Ross T Warrington
Shixuan Wang
P2860
P304
P356
10.1091/MBC.E11-05-0389
P577
2011-09-21T00:00:00Z