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Progress towards mechanism-based treatment for Diamond-Blackfan anemiaRibosomal proteins as unrevealed caretakers for cellular stress and genomic instabilityPerturbations at the ribosomal genes loci are at the centre of cellular dysfunction and human diseaseStructure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activationRole of ribosomal protein mutations in tumor development (Review)mTOR: An attractive therapeutic target for osteosarcoma?Ribosomal protein S7 regulates arsenite-induced GADD45α expression by attenuating MDM2-mediated GADD45α ubiquitination and degradationShort hairpin RNA library-based functional screening identified ribosomal protein L31 that modulates prostate cancer cell growth via p53 pathwayRibosomal proteins and human diseases: pathogenesis, molecular mechanisms, and therapeutic implicationsNuclear PRAS40 couples the Akt/mTORC1 signaling axis to the RPL11-HDM2-p53 nucleolar stress response pathway.MDM2 SNP309 promoter polymorphism and p53 mutations in urinary bladder carcinoma stage T1.Intravital imaging reveals p53-dependent cancer cell death induced by phototherapy via calcium signaling.Network modeling of MDM2 inhibitor-oxaliplatin combination reveals biological synergy in wt-p53 solid tumors.Downregulation of Mdm2 and Mdm4 enhances viral gene expression during adenovirus infection.Chaperoning 5S RNA assembly.Nucleolar GTP-binding Protein-1 (NGP-1) Promotes G1 to S Phase Transition by Activating Cyclin-dependent Kinase Inhibitor p21 Cip1/Waf1.p63 the guardian of human reproduction.On the interaction mechanisms of a p53 peptide and nutlin with the MDM2 and MDMX proteins: a Brownian dynamics study.Recent discoveries in the cycling, growing and aging of the p53 fieldOncogenic c-Myc-induced lymphomagenesis is inhibited non-redundantly by the p19Arf-Mdm2-p53 and RP-Mdm2-p53 pathwaysThe Role of p53 and MDM2 in Head and Neck Cancer.DNA damage-induced activation of ATM promotes β-TRCP-mediated Mdm2 ubiquitination and destructionA cell-free approach to accelerate the study of protein-protein interactions in vitro.Regulation of the HDM2-p53 pathway by ribosomal protein L6 in response to ribosomal stress.The regulation of MDM2 oncogene and its impact on human cancers.Important molecular genetic markers of colorectal cancer.AKT mediates actinomycin D-induced p53 expression.Role of uL3 in Multidrug Resistance in p53-Mutated Lung Cancer Cells.Deletion of ribosomal protein genes is a common vulnerability in human cancer, especially in concert with TP53 mutations.Regulation of p53: a collaboration between Mdm2 and Mdmx.Nuclear bodies: multifunctional companions of the genome.Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications.Effects of murine double minute 2 polymorphisms on the risk and survival of osteosarcoma: a systemic review and meta-analysis.p53 -Dependent and -Independent Nucleolar Stress Responses.mTOR inhibitors blunt the p53 response to nucleolar stress by regulating RPL11 and MDM2 levels.Human rpL3 plays a crucial role in cell response to nucleolar stress induced by 5-FU and L-OHP.Ribosomal stress activates eEF2K-eEF2 pathway causing translation elongation inhibition and recruitment of terminal oligopyrimidine (TOP) mRNAs on polysomesHuman rpL3 induces G₁/S arrest or apoptosis by modulating p21 (waf1/cip1) levels in a p53-independent manner.p53 expression controls prostate cancer sensitivity to chemotherapy and the MDM2 inhibitor Nutlin-3.cIAP2 represses IKKα/β-mediated activation of MDM2 to prevent p53 degradation.
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description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
The RP-Mdm2-p53 pathway and tumorigenesis
@ast
The RP-Mdm2-p53 pathway and tumorigenesis
@en
type
label
The RP-Mdm2-p53 pathway and tumorigenesis
@ast
The RP-Mdm2-p53 pathway and tumorigenesis
@en
prefLabel
The RP-Mdm2-p53 pathway and tumorigenesis
@ast
The RP-Mdm2-p53 pathway and tumorigenesis
@en
P2860
P921
P356
P1433
P1476
The RP-Mdm2-p53 pathway and tumorigenesis
@en
P2093
Paula L Miliani de Marval
Yanping Zhang
P2860
P304
P356
10.18632/ONCOTARGET.228
P407
P5008
P577
2011-03-01T00:00:00Z