Chemical informatics and target identification in a zebrafish phenotypic screen. - Wikidata - awgldk - TriplyDB

Chemical informatics and target identification in a zebrafish phenotypic screen.

Chemical informatics and target identification in a zebrafish phenotypic screen.

http://www.wikidata.org/entity/Q35683136

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Regulation of zebrafish sleep and arousal states: current and prospective approaches Zebrafish as an emerging model for studying complex brain disorders Toward developmental models of psychiatric disorders in zebrafish Shifting from the single to the multitarget paradigm in drug discovery Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feeding Drug screening: zebrafish as a tool for studying epileptic-related chemical compounds The Impact of Introducing a Histidine into an Apolar Cavity Site on Docking and Ligand Recognition Large-scale chemical similarity networks for target profiling of compounds identified in cell-based chemical screens Application of RNAi to Genomic Drug Target Validation in Schistosomes Leveraging Large-scale Behavioral Profiling in Zebrafish to Explore Neuroactive Polypharmacology.Behavioral barcoding in the cloud: embracing data-intensive digital phenotyping in neuropharmacology Developing highER-throughput zebrafish screens for in-vivo CNS drug discovery.Statistical Analysis of Zebrafish Locomotor Behaviour by Generalized Linear Mixed Models Identifying mechanism-of-action targets for drugs and probes.Target deconvolution techniques in modern phenotypic profiling.A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism.Target identification and mechanism of action in chemical biology and drug discovery.Anesthetic drug development: Novel drugs and new approaches.Computational studies to predict or explain G protein coupled receptor polypharmacology Balancing novelty with confined chemical space in modern drug discovery.Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes Extending in silico mechanism-of-action analysis by annotating targets with pathways: application to cellular cytotoxicity readouts.Protein homology reveals new targets for bioactive small molecules.Integrated Approaches for Genome-wide Interrogation of the Druggable Non-olfactory G Protein-coupled Receptor Superfamily.From phenotype to mechanism after zebrafish small molecule screens.Large-scale prediction and testing of drug activity on side-effect targets.In vivo chemical screening for modulators of hematopoiesis and hematological diseases Ligand Similarity Complements Sequence, Physical Interaction, and Co-Expression for Gene Function Prediction.Activity-Independent Discovery of Secondary Metabolites Using Chemical Elicitation and Cheminformatic Inference The Zebrafish as a Tool to Cancer Drug Discovery.ALDH2 mediates 5-nitrofuran activity in multiple species.Changing the Scale and Efficiency of Chemical Warfare Countermeasure Discovery Using the Zebrafish.Advances in zebrafish chemical screening technologies.Towards systems biology of mycotoxin regulation.LITTLE FISH, BIG DATA: ZEBRAFISH AS A MODEL FOR CARDIOVASCULAR AND METABOLIC DISEASE.Narrowing the translational research gap: what needs to be done?Drug Metabolism in Preclinical Drug Development: A Survey of the Discovery Process, Toxicology, and Computational Tools.Regulated expression of pH sensing G Protein-coupled receptor-68 identified through chemical biology defines a new drug target for ischemic heart disease.Towards the Next Generation of Computational Chemogenomics Tools.

P2860

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P2860

Chemical informatics and target identification in a zebrafish phenotypic screen.

http://www.wikidata.org/entity/Q35683136

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2011年论文

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2011年论文

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2011年论文

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name

Chemical informatics and target identification in a zebrafish phenotypic screen.

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Chemical informatics and target identification in a zebrafish phenotypic screen.

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type

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Chemical informatics and target identification in a zebrafish phenotypic screen.

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Chemical informatics and target identification in a zebrafish phenotypic screen.

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Chemical informatics and target identification in a zebrafish phenotypic screen.

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Chemical informatics and target identification in a zebrafish phenotypic screen.

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Nature Chemical Biology

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Chemical informatics and target identification in a zebrafish phenotypic screen

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Alexandra Tolia

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Brian K Shoichet

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Bryan L Roth

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Christian Laggner

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Chung Yan J Cheung

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Daniel L Minor

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Henry Lin

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Randall T Peterson

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Vincent Setola

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P2860

A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase

Predicting new molecular targets for known drugs

Basic local alignment search tool

Chemical Similarity Searching

Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen

Small molecules: the missing link in the central dogma

Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis

Drug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosis

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

Drug-target network

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10.1038/NCHEMBIO.732

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2

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8

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Michael J Keiser

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2011-12-18T00:00:00Z

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51897642

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22179068

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3262069

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