Chemical informatics and target identification in a zebrafish phenotypic screen.
about
Regulation of zebrafish sleep and arousal states: current and prospective approachesZebrafish as an emerging model for studying complex brain disordersToward developmental models of psychiatric disorders in zebrafishShifting from the single to the multitarget paradigm in drug discoveryMetabolomics and systems pharmacology: why and how to model the human metabolic network for drug discoveryIn silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feedingDrug screening: zebrafish as a tool for studying epileptic-related chemical compoundsThe Impact of Introducing a Histidine into an Apolar Cavity Site on Docking and Ligand RecognitionLarge-scale chemical similarity networks for target profiling of compounds identified in cell-based chemical screensApplication of RNAi to Genomic Drug Target Validation in SchistosomesLeveraging Large-scale Behavioral Profiling in Zebrafish to Explore Neuroactive Polypharmacology.Behavioral barcoding in the cloud: embracing data-intensive digital phenotyping in neuropharmacologyDeveloping highER-throughput zebrafish screens for in-vivo CNS drug discovery.Statistical Analysis of Zebrafish Locomotor Behaviour by Generalized Linear Mixed ModelsIdentifying mechanism-of-action targets for drugs and probes.Target deconvolution techniques in modern phenotypic profiling.A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism.Target identification and mechanism of action in chemical biology and drug discovery.Anesthetic drug development: Novel drugs and new approaches.Computational studies to predict or explain G protein coupled receptor polypharmacologyBalancing novelty with confined chemical space in modern drug discovery.Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetesExtending in silico mechanism-of-action analysis by annotating targets with pathways: application to cellular cytotoxicity readouts.Protein homology reveals new targets for bioactive small molecules.Integrated Approaches for Genome-wide Interrogation of the Druggable Non-olfactory G Protein-coupled Receptor Superfamily.From phenotype to mechanism after zebrafish small molecule screens.Large-scale prediction and testing of drug activity on side-effect targets.In vivo chemical screening for modulators of hematopoiesis and hematological diseasesLigand Similarity Complements Sequence, Physical Interaction, and Co-Expression for Gene Function Prediction.Activity-Independent Discovery of Secondary Metabolites Using Chemical Elicitation and Cheminformatic InferenceThe Zebrafish as a Tool to Cancer Drug Discovery.ALDH2 mediates 5-nitrofuran activity in multiple species.Changing the Scale and Efficiency of Chemical Warfare Countermeasure Discovery Using the Zebrafish.Advances in zebrafish chemical screening technologies.Towards systems biology of mycotoxin regulation.LITTLE FISH, BIG DATA: ZEBRAFISH AS A MODEL FOR CARDIOVASCULAR AND METABOLIC DISEASE.Narrowing the translational research gap: what needs to be done?Drug Metabolism in Preclinical Drug Development: A Survey of the Discovery Process, Toxicology, and Computational Tools.Regulated expression of pH sensing G Protein-coupled receptor-68 identified through chemical biology defines a new drug target for ischemic heart disease.Towards the Next Generation of Computational Chemogenomics Tools.
P2860
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P2860
Chemical informatics and target identification in a zebrafish phenotypic screen.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Chemical informatics and target identification in a zebrafish phenotypic screen.
@ast
Chemical informatics and target identification in a zebrafish phenotypic screen.
@en
type
label
Chemical informatics and target identification in a zebrafish phenotypic screen.
@ast
Chemical informatics and target identification in a zebrafish phenotypic screen.
@en
prefLabel
Chemical informatics and target identification in a zebrafish phenotypic screen.
@ast
Chemical informatics and target identification in a zebrafish phenotypic screen.
@en
P2093
P2860
P50
P356
P1476
Chemical informatics and target identification in a zebrafish phenotypic screen
@en
P2093
Alexandra Tolia
Brian K Shoichet
Bryan L Roth
Christian Laggner
Chung Yan J Cheung
Daniel L Minor
Randall T Peterson
Vincent Setola
P2860
P2888
P304
P356
10.1038/NCHEMBIO.732
P577
2011-12-18T00:00:00Z