Functional characterization of Candida albicans ABC transporter Cdr1p.
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The ABCs of Candida albicans Multidrug Transporter Cdr1Rational mutational analysis of a multidrug MFS transporter CaMdr1p of Candida albicans by employing a membrane environment based computational approachXenobiotic efflux in bacteria and fungi: a genomics updateThe amino acid residues of transmembrane helix 5 of multidrug resistance protein CaCdr1p of Candida albicans are involved in substrate specificity and drug transportProbing of multidrug ABC membrane transporters of single living cells using single plasmonic nanoparticle optical probes.Fungal PDR transporters: Phylogeny, topology, motifs and function.Design and probing of efflux functions of EGFP fused ABC membrane transporters in live cells using fluorescence spectroscopy.Functional analysis of CaIPT1, a sphingolipid biosynthetic gene involved in multidrug resistance and morphogenesis of Candida albicans.Divergent signature motifs of nucleotide binding domains of ABC multidrug transporter, CaCdr1p of pathogenic Candida albicans, are functionally asymmetric and noninterchangeableHeterozygosity and functional allelic variation in the Candida albicans efflux pump genes CDR1 and CDR2.Mutational Analysis of Intracellular Loops Identify Cross Talk with Nucleotide Binding Domains of Yeast ABC Transporter Cdr1p.In vitro effect of malachite green on Candida albicans involves multiple pathways and transcriptional regulators UPC2 and STP2.Miconazole induces fungistasis and increases killing of Candida albicans subjected to photodynamic therapyP-Glycoprotein is not present in mitochondrial membranes.An update on antifungal targets and mechanisms of resistance in Candida albicans.Mutation of G234 amino acid residue in candida albicans drug-resistance-related protein Rta2p is associated with fluconazole resistance and dihydrosphingosine transportA New Endogenous Overexpression System of Multidrug Transporters of Candida albicans Suitable for Structural and Functional Studies.Antifungal Action of Methylene Blue Involves Mitochondrial Dysfunction and Disruption of Redox and Membrane Homeostasis in C. albicans.Candida drug resistance protein 1, a major multidrug ATP binding cassette transporter of Candida albicans, translocates fluorescent phospholipids in a reconstituted system.The multidrug transporter Pdr5 on the 25th anniversary of its discovery: an important model for the study of asymmetric ABC transportersCandida albicans flu1-mediated efflux of salivary histatin 5 reduces its cytosolic concentration and fungicidal activityConserved Asp327 of walker B motif in the N-terminal nucleotide binding domain (NBD-1) of Cdr1p of Candida albicans has acquired a new role in ATP hydrolysisChemical and pharmacological chaperones as new therapeutic agents.Rationally designed transmembrane peptide mimics of the multidrug transporter protein Cdr1 act as antagonists to selectively block drug efflux and chemosensitize azole-resistant clinical isolates of Candida albicans.Pleiotropic effects of the vacuolar ABC transporter MLT1 of Candida albicans on cell function and virulence.Mutations define cross-talk between the N-terminal nucleotide-binding domain and transmembrane helix-2 of the yeast multidrug transporter Pdr5: possible conservation of a signaling interface for coupling ATP hydrolysis to drug transportRelative contributions of the Candida albicans ABC transporters Cdr1p and Cdr2p to clinical azole resistanceEfflux-mediated antifungal drug resistance.Curcumin modulates efflux mediated by yeast ABC multidrug transporters and is synergistic with antifungals.Membrane sphingolipid-ergosterol interactions are important determinants of multidrug resistance in Candida albicans.Efflux pump proteins in antifungal resistance.Raft-like membrane domains in pathogenic microorganisms.The quorum-sensing molecule farnesol is a modulator of drug efflux mediated by ABC multidrug transporters and synergizes with drugs in Candida albicans.The Candida albicans GAP gene family encodes permeases involved in general and specific amino acid uptake and sensingCandida Efflux ATPases and Antiporters in Clinical Drug Resistance.Targeting efflux pumps to overcome antifungal drug resistance.Functionally Relevant Residues of Cdr1p: A Multidrug ABC Transporter of Human Pathogenic Candida albicans.Sesamol: a natural phenolic compound with promising anticandidal potential.Transcriptional activation and increased mRNA stability contribute to overexpression of CDR1 in azole-resistant Candida albicansMultidrug transporters CaCdr1p and CaMdr1p of Candida albicans display different lipid specificities: both ergosterol and sphingolipids are essential for targeting of CaCdr1p to membrane rafts.
P2860
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P2860
Functional characterization of Candida albicans ABC transporter Cdr1p.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Functional characterization of Candida albicans ABC transporter Cdr1p.
@ast
Functional characterization of Candida albicans ABC transporter Cdr1p.
@en
type
label
Functional characterization of Candida albicans ABC transporter Cdr1p.
@ast
Functional characterization of Candida albicans ABC transporter Cdr1p.
@en
prefLabel
Functional characterization of Candida albicans ABC transporter Cdr1p.
@ast
Functional characterization of Candida albicans ABC transporter Cdr1p.
@en
P2093
P2860
P1433
P1476
Functional characterization of Candida albicans ABC transporter Cdr1p
@en
P2093
Preeti Saini
Rajendra Prasad
Suneet Shukla
Suresh V Ambudkar
P2860
P304
P356
10.1128/EC.2.6.1361-1375.2003
P50
P577
2003-12-01T00:00:00Z