SIRT1 contains N- and C-terminal regions that potentiate deacetylase activity.
about
Structural basis for sirtuin activity and inhibitionStructural and Functional Analysis of Human SIRT1Crystal structure of the N-terminal domain of human SIRT7 reveals a three-helical domain architectureEvidence for a common mechanism of SIRT1 regulation by allosteric activatorsSmall-molecule allosteric activators of sirtuins.Sirt1 carboxyl-domain is an ATP-repressible domain that is transferrable to other proteins.Energy restriction and potential energy restriction mimetics.The multifunctional sorting protein PACS-2 regulates SIRT1-mediated deacetylation of p53 to modulate p21-dependent cell-cycle arrest.Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrolUsing mitochondrial sirtuins as drug targets: disease implications and available compounds.The N-Terminal Domain of SIRT1 Is a Positive Regulator of Endogenous SIRT1-Dependent Deacetylation and Transcriptional OutputsDeacetylation by SIRT1 Reprograms Inflammation and CancerThe emerging and diverse roles of sirtuins in cancer: a clinical perspective.Unreported intrinsic disorder in proteins: Building connections to the literature on IDPs.The sirtuin class of histone deacetylases: regulation and roles in lipid metabolism.Chemical and structural biology of protein lysine deacetylasesBiochemistry. Red wine, toast of the town (again)Jamming up the "β-staple": regulation of SIRT1 activity by its C-terminal regulatory segment (CTR).Molecular architecture of the human protein deacetylase Sirt1 and its regulation by AROS and resveratrol.Crystallographic structure of a small molecule SIRT1 activator-enzyme complex.A novel sirtuin 2 (SIRT2) inhibitor with p53-dependent pro-apoptotic activity in non-small cell lung cancer.Mechanism of Sirt1 NAD+-dependent Protein Deacetylase Inhibition by Cysteine S-Nitrosation.Sirt1 interaction with active Smad2 modulates transforming growth factor-β regulated transcription.The crystal structure of the Leishmania infantum Silent Information Regulator 2 related protein 1: Implications to protein function and drug design.
P2860
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P2860
SIRT1 contains N- and C-terminal regions that potentiate deacetylase activity.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
SIRT1 contains N- and C-terminal regions that potentiate deacetylase activity.
@ast
SIRT1 contains N- and C-terminal regions that potentiate deacetylase activity.
@en
type
label
SIRT1 contains N- and C-terminal regions that potentiate deacetylase activity.
@ast
SIRT1 contains N- and C-terminal regions that potentiate deacetylase activity.
@en
prefLabel
SIRT1 contains N- and C-terminal regions that potentiate deacetylase activity.
@ast
SIRT1 contains N- and C-terminal regions that potentiate deacetylase activity.
@en
P2093
P2860
P356
P1476
SIRT1 contains N- and C-terminal regions that potentiate deacetylase activity.
@en
P2093
Emily Chen Ding
Michael Brent
Ronen Marmorstein
P2860
P304
P356
10.1074/JBC.M111.285031
P407
P577
2011-12-07T00:00:00Z