Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin
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Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylaseSirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activityCrystal structures of human SIRT3 displaying substrate-induced conformational changesEvolution of the arginase fold and functional diversityStructural basis for sirtuin activity and inhibitionProtein lysine acylation and cysteine succination by intermediates of energy metabolismThe Bicyclic Intermediate Structure Provides Insights into the Desuccinylation Mechanism of Human Sirtuin 5 (SIRT5)A Molecular Mechanism for Direct Sirtuin Activation by ResveratrolStructural and Functional Analysis of Human SIRT1Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.An acetylome peptide microarray reveals specificities and deacetylation substrates for all human sirtuin isoforms.Inhibitors of the NAD(+)-Dependent Protein Desuccinylase and Demalonylase Sirt5Modulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectivesRejuvenating sirtuins: the rise of a new family of cancer drug targetsSirtuin regulation of mitochondria: energy production, apoptosis, and signaling.Structure-based development of novel sirtuin inhibitors.Identification and characterization of novel sirtuin inhibitor scaffoldsSirt5 deacylation activities show differential sensitivities to nicotinamide inhibition.Epigenetic drugs against cancer: an evolving landscape.Structure and biochemical functions of SIRT6.The human sirtuin family: evolutionary divergences and functions.Selectivity hot-spots of sirtuin catalytic cores.SIRT1 contains N- and C-terminal regions that potentiate deacetylase activity.Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrolUsing mitochondrial sirtuins as drug targets: disease implications and available compounds.The sirtuins in the pathogenesis of cancer.Sirtuin modulators.Identification of sirtuin 5 inhibitors by ultrafast microchip electrophoresis using nanoliter volume samplesTen years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases.Chemistry of acetyl transfer by histone modifying enzymes: structure, mechanism and implications for effector design.Anaplasma phagocytophilum increases the levels of histone modifying enzymes to inhibit cell apoptosis and facilitate pathogen infection in the tick vector Ixodes scapularis.The emerging and diverse roles of sirtuins in cancer: a clinical perspective.Computational studies on the histone deacetylases and the design of selective histone deacetylase inhibitors.Sirtuin inhibitors.Structural basis for sirtuin function: what we know and what we don't.Erasers of histone acetylation: the histone deacetylase enzymes.p53-based cancer therapySirtuin 1 (SIRT1): the misunderstood HDAC.Sirtuins and disease: the road ahead.Sirtuin activators and inhibitors.
P2860
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P2860
Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin
description
2007 nî lūn-bûn
@nan
2007 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մարտին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin
@ast
Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin
@en
Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin
@nl
type
label
Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin
@ast
Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin
@en
Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin
@nl
prefLabel
Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin
@ast
Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin
@en
Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin
@nl
P2093
P50
P1433
P1476
Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin
@en
P2093
Aiping Dong
Alexander N Plotnikov
Anja Schuetz
Chia-Lin Wang
Jinrong Min
P304
P356
10.1016/J.STR.2007.02.002
P50
P577
2007-03-01T00:00:00Z