Distribution, functionality and gene regulation of folate receptor isoforms: implications in targeted therapy.
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Structural basis for molecular recognition of folic acid by folate receptorsSynthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibitTargeting folate receptor alpha for cancer treatmentTargeted drug delivery via folate receptors in recurrent ovarian cancer: a reviewMechanisms and implications of dual-acting methotrexate in folate-targeted nanotherapeutic deliveryFarletuzumab in lung cancerBiology of the major facilitative folate transporters SLC19A1 and SLC46A1Nanoparticle-based targeted therapeutics in head-and-neck cancerDevelopment and binding mode assessment of N-[4-[2-propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-γ-glutamyl-D-glutamic acid (BGC 945), a novel thymidylate synthase inhibitor that targetsStructures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognitionNanoparticles for Improving Cancer Diagnosis.Association of MTHFR gene polymorphisms with breast cancer survival.Hydrophobically modified carboxymethyl chitosan nanoparticles targeted delivery of paclitaxel.One-carbon metabolism and nucleotide biosynthesis as attractive targets for anticancer therapy.Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over theGCPII imaging and cancer.Emerging immunotherapeutics in adenocarcinomas: A focus on CAR-T cellsA folate receptor beta-specific human monoclonal antibody recognizes activated macrophage of rheumatoid patients and mediates antibody-dependent cell-mediated cytotoxicity.Expression status of folate receptor alpha is a predictor of survival in pancreatic ductal adenocarcinoma.Targeted dendrimeric anticancer prodrug: a methotrexate-folic acid-poly(amidoamine) conjugate and a novel, rapid, "one pot" synthetic approachFolate-receptor 1 (FOLR1) protein is elevated in the serum of ovarian cancer patients.Lack of association between folate-receptor autoantibodies and neural-tube defects.Tumor cell targeting using folate-conjugated fluorescent quantum dots and receptor-mediated endocytosis.The obligatory intestinal folate transporter PCFT (SLC46A1) is regulated by nuclear respiratory factor 1.Mechanisms of membrane transport of folates into cells and across epithelia.Bioengineering strategies for designing targeted cancer therapiesTherapeutic targeting of a novel 6-substituted pyrrolo [2,3-d]pyrimidine thienoyl antifolate to human solid tumors based on selective uptake by the proton-coupled folate transporterAndrogen activation of the folate receptor α gene through partial tethering of the androgen receptor by C/EBPα.The human proton-coupled folate transporter: Biology and therapeutic applications to cancer.A novel splice variant of folate receptor 4 predominantly expressed in regulatory T cells.Targeting the proton-coupled folate transporter for selective delivery of 6-substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of de novo purine biosynthesis in the chemotherapy of solid tumors.Structure-activity profiles of novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolates with modified amino acids for cellular uptake by folate receptors α and β and the proton-coupled folate transporterThe ABCs of membrane transporters in health and disease (SLC series): introduction.Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors.Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma.Folic acid-tethered Pep-1 peptide-conjugated liposomal nanocarrier for enhanced intracellular drug delivery to cancer cells: conformational characterization and in vitro cellular uptake evaluation.The reduced folate carrier (RFC) is cytotoxic to cells under conditions of severe folate deprivation. RFC as a double edged sword in folate homeostasisMembrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues.Intracellular trafficking considerations in the development of natural ligand-drug molecular conjugates for cancer.Treatment of experimental adjuvant arthritis with a novel folate receptor-targeted folic acid-aminopterin conjugate.
P2860
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P2860
Distribution, functionality and gene regulation of folate receptor isoforms: implications in targeted therapy.
description
2004 nî lūn-bûn
@nan
2004年の論文
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2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
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2004年論文
@zh-tw
2004年论文
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2004年论文
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2004年论文
@zh-cn
name
Distribution, functionality an ...... lications in targeted therapy.
@ast
Distribution, functionality an ...... lications in targeted therapy.
@en
type
label
Distribution, functionality an ...... lications in targeted therapy.
@ast
Distribution, functionality an ...... lications in targeted therapy.
@en
prefLabel
Distribution, functionality an ...... lications in targeted therapy.
@ast
Distribution, functionality an ...... lications in targeted therapy.
@en
P1476
Distribution, functionality an ...... lications in targeted therapy.
@en
P2093
Hala Elnakat
Manohar Ratnam
P304
P356
10.1016/J.ADDR.2004.01.001
P407
P577
2004-04-01T00:00:00Z