Aβ neurotoxicity depends on interactions between copper ions, prion protein, and N-methyl-D-aspartate receptors
about
A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer's diseaseAmyloid beta precursor protein and prion protein have a conserved interaction affecting cell adhesion and CNS developmentLow levels of copper disrupt brain amyloid-β homeostasis by altering its production and clearanceMulti-Target Directed Donepezil-Like Ligands for Alzheimer's DiseaseAmyloid-β-Induced Dysregulation of AMPA Receptor TraffickingMetallothionein and stress combine to affect multiple organ systemsCopper signaling in the mammalian nervous system: synaptic effectsAmyloid-β induced signaling by cellular prion protein and Fyn kinase in Alzheimer diseaseHijacking PrP(c)-dependent signal transduction: when prions impair Aβ clearanceNCAM1 Polysialylation: The Prion Protein's Elusive Reason for Being?Cell line specific modulation of extracellular aβ42 by Hsp40Solvent microenvironments and copper binding alters the conformation and toxicity of a prion fragmentAlzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons.The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6Pam heterozygous mice reveal essential role for Cu in amygdalar behavioral and synaptic functionThe biological function of the cellular prion protein: an updateMetals and cholesterol: two sides of the same coin in Alzheimer's disease pathology.Amyloid β Protein and Alzheimer's Disease: When Computer Simulations Complement Experimental Studies.Cellular prion protein and NMDA receptor modulation: protecting against excitotoxicity.Copper is an endogenous modulator of neural circuit spontaneous activity.Primary blast-induced traumatic brain injury in rats leads to increased prion protein in plasma: a potential biomarker for blast-induced traumatic brain injuryTranslation of the prion protein mRNA is robust in astrocytes but does not amplify during reactive astrocytosis in the mouse brainHigh resolution imaging study of interactions between the 37 kDa/67 kDa laminin receptor and APP, beta-secretase and gamma-secretase in Alzheimer's disease.Transgenic fatal familial insomnia mice indicate prion infectivity-independent mechanisms of pathogenesis and phenotypic expression of disease.Lipid rafts and Alzheimer's disease: protein-lipid interactions and perturbation of signaling.Autonomous requirements of the Menkes disease protein in the nervous system.An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivoThe neurodegeneration in Alzheimer disease and the prion proteinAmyloid-β Peptide Aβ3pE-42 Induces Lipid Peroxidation, Membrane Permeabilization, and Calcium Influx in Neurons.A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicityInteraction between Prion Protein's Copper-Bound Octarepeat Domain and a Charged C-Terminal Pocket Suggests a Mechanism for N-Terminal Regulation.Role of the P-Type ATPases, ATP7A and ATP7B in brain copper homeostasis.The cellular prion protein traps Alzheimer's Aβ in an oligomeric form and disassembles amyloid fibers.Synaptic dysfunction in prion diseases: a trafficking problem?Selective vulnerability to neurodegenerative disease: the curious case of Prion Protein.A new paradigm for enzymatic control of α-cleavage and β-cleavage of the prion protein.In vivo bioluminescence imaging reveals copper deficiency in a murine model of nonalcoholic fatty liver disease.Fyn kinase inhibition as a novel therapy for Alzheimer's disease.Copper-dependent regulation of NMDA receptors by cellular prion protein: implications for neurodegenerative disorders.Prion propagation, toxicity and degradation.
P2860
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P2860
Aβ neurotoxicity depends on interactions between copper ions, prion protein, and N-methyl-D-aspartate receptors
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Aβ neurotoxicity depends on in ...... N-methyl-D-aspartate receptors
@ast
Aβ neurotoxicity depends on in ...... N-methyl-D-aspartate receptors
@en
type
label
Aβ neurotoxicity depends on in ...... N-methyl-D-aspartate receptors
@ast
Aβ neurotoxicity depends on in ...... N-methyl-D-aspartate receptors
@en
prefLabel
Aβ neurotoxicity depends on in ...... N-methyl-D-aspartate receptors
@ast
Aβ neurotoxicity depends on in ...... N-methyl-D-aspartate receptors
@en
P2093
P2860
P356
P1476
Aβ neurotoxicity depends on in ...... N-methyl-D-aspartate receptors
@en
P2093
Haitao You
Jordan D T Engbers
Peter K Stys
Shahid Hameed
Shigeki Tsutsui
Stuart A Lipton
Thomas J Kannanayakal
P2860
P304
P356
10.1073/PNAS.1110789109
P407
P577
2012-01-17T00:00:00Z