G protein-coupled receptor kinase 2 plays a relevant role in insulin resistance and obesity - Wikidata - awgldk - TriplyDB

G protein-coupled receptor kinase 2 plays a relevant role in insulin resistance and obesity

G protein-coupled receptor kinase 2 plays a relevant role in insulin resistance and obesity

http://www.wikidata.org/entity/Q35757227

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GRK2: multiple roles beyond G protein-coupled receptor desensitization G-protein-coupled receptor kinase 2 and endothelial dysfunction: molecular insights and pathophysiological mechanisms G protein-coupled receptor kinase 2: a link between myocardial contractile function and cardiac metabolism Insulin induces IRS2-dependent and GRK2-mediated β2AR internalization to attenuate βAR signaling in cardiomyocytes.Kinome Screen Identifies PFKFB3 and Glucose Metabolism as Important Regulators of the Insulin/Insulin-like Growth Factor (IGF)-1 Signaling Pathway Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2 G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia.G protein-coupled receptor kinases: more than just kinases and not only for GPCRs Bacillus bombysepticus α-Toxin Binding to G Protein-Coupled Receptor Kinase 2 Regulates cAMP/PKA Signaling Pathway to Induce Host Death.Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2.GRK2 compromises cardiomyocyte mitochondrial function by diminishing fatty acid-mediated oxygen consumption and increasing superoxide levels Evaluation of the association between the ADRA2A genetic polymorphisms and type 2 diabetes in a Chinese Han population.Improvement of vascular insulin sensitivity by downregulation of GRK2 mediates exercise-induced alleviation of hypertension in spontaneously hypertensive rats Adrenergic receptors and metabolism: role in development of cardiovascular disease Adrenergic signaling and oxidative stress: a role for sirtuins?G Protein-coupled receptor kinase 2 (GRK2): A novel modulator of insulin resistance.The connection between GRKs and various signaling pathways involved in diabetic nephropathy.Molecular physiopathology of obesity-related diseases: multi-organ integration by GRK2.Role of G protein-coupled receptor kinase 2 in tumoral angiogenesis.Pro-inflammatory cytokines mediate GPCR dysfunction.Targeting GPCR-Gβγ-GRK2 signaling as a novel strategy for treating cardiorenal pathologies.GRK2 negatively regulates IGF-1R signaling pathway and cyclins' expression in HepG2 cells.Noncanonical Roles of G Protein-coupled Receptor Kinases in Cardiovascular Signaling.Cross-Talk Between Insulin Signaling and G Protein-Coupled Receptors.Obesity-induced cardiac lipid accumulation in adult mice is modulated by G protein-coupled receptor kinase 2 levels.Suppression of GRK2 expression reduces endothelial dysfunction by restoring glucose homeostasis.Skeletal Muscle-specific G Protein-coupled Receptor Kinase 2 Ablation Alters Isolated Skeletal Muscle Mechanics and Enhances Clenbuterol-stimulated Hypertrophy.Comment on Sato et al. Improving type 2 diabetes through a distinct adrenergic signaling pathway involving mTORC2 that mediates glucose uptake in skeletal muscle. Diabetes 2014;63:4115-4129.Inhibiting Insulin-Mediated β2-Adrenergic Receptor Activation Prevents Diabetes-Associated Cardiac Dysfunction.Renoprotective effects of berberine and its possible molecular mechanisms in combination of high-fat diet and low-dose streptozotocin-induced diabetic rats.Skeletal muscle myogenesis is regulated by G protein-coupled receptor kinase 2.Stevioside modulates oxidative damage in the liver and kidney of high fat/low streptozocin diabetic rats.Designer Approaches for G Protein-Coupled Receptor Modulation for Cardiovascular Disease New Insights in Cardiac β-Adrenergic Signaling During Heart Failure and Aging

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P2860

G protein-coupled receptor kinase 2 plays a relevant role in insulin resistance and obesity

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2010 nî lūn-bûn

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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2010年论文

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2010年论文

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name

G protein-coupled receptor kin ...... insulin resistance and obesity

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G protein-coupled receptor kin ...... insulin resistance and obesity

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G protein-coupled receptor kin ...... insulin resistance and obesity

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G protein-coupled receptor kin ...... insulin resistance and obesity

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G protein-coupled receptor kin ...... insulin resistance and obesity

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G protein-coupled receptor kin ...... insulin resistance and obesity

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G protein-coupled receptor kin ...... insulin resistance and obesity

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Cristina Murga

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Federico Mayor

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Iria Nieto-Vazquez

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Javier Díez

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Lucia Garcia-Guerra

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Margarita Lorenzo

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María Jurado-Pueyo

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P2860

Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2

Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice

IRS1-independent defects define major nodes of insulin resistance

The G protein-coupled receptor kinase (GRK) interactome: role of GRKs in GPCR regulation and signaling

Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function

Rosiglitazone restores renal D1A receptor-Gs protein coupling by reducing receptor hyperphosphorylation in obese rats

Insulin induces heterologous desensitization of G-protein-coupled receptor and insulin-like growth factor I signaling by downregulating beta-arrestin-1.

Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

Beta -Arrestin 1 down-regulation after insulin treatment is associated with supersensitization of beta 2 adrenergic receptor Galpha s signaling in 3T3-L1 adipocytes.

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2407-2417

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scholarly article

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10.2337/DB10-0771

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10

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59

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Sonia Fernández-Veledo

Rocio Vila-Bedmar

Guillermo Zalba

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2010-07-13T00:00:00Z

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45185174

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20627936

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G protein-coupled receptor

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3279564

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