A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Aβ on synapses and dendritic spines
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Alzheimer mechanisms and therapeutic strategiesRole of individual MARK isoforms in phosphorylation of tau at Ser²⁶² in Alzheimer's diseaseThe dendritic hypothesis for Alzheimer's disease pathophysiology.The Ubiquitin-Proteasome System and Molecular Chaperone Deregulation in Alzheimer's DiseaseOverexpression of 14-3-3z promotes tau phosphorylation at Ser262 and accelerates proteosomal degradation of synaptophysin in rat primary hippocampal neuronsRoles of tau protein in health and disease.DAWN: a framework to identify autism genes and subnetworks using gene expression and genetics.MARK4 and MARK3 associate with early tau phosphorylation in Alzheimer's disease granulovacuolar degeneration bodies.Acetylation: a new key to unlock tau's role in neurodegenerationMARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanismβ-Amyloid inhibits E-S potentiation through suppression of cannabinoid receptor 1-dependent synaptic disinhibitionProtein tau: prime cause of synaptic and neuronal degeneration in Alzheimer's disease.Dahl (S × R) rat congenic strain analysis confirms and defines a chromosome 17 spatial navigation quantitative trait locus to <10 MbpTau aggregation and its interplay with amyloid-β.Phospho-dependent ubiquitination and degradation of PAR-1 regulates synaptic morphology and tau-mediated Aβ toxicity in Drosophila.Rescue of tau-induced synaptic transmission pathology by paclitaxel.MARK/Par1 Kinase Is Activated Downstream of NMDA Receptors through a PKA-Dependent Mechanism.Stabilization of Microtubule-Unbound Tau via Tau Phosphorylation at Ser262/356 by Par-1/MARK Contributes to Augmentation of AD-Related Phosphorylation and Aβ42-Induced Tau Toxicity.Active zone proteins are transported via distinct mechanisms regulated by Par-1 kinase.Soluble forms of tau are toxic in Alzheimer's disease.Fasting and Systemic Insulin Signaling Regulate Phosphorylation of Brain Proteins That Modulate Cell Morphology and Link to Neurological Disorders.Mark4 promotes oxidative stress and inflammation via binding to PPARγ and activating NF-κB pathway in mice adipocytes.Phosphorylation of FEZ1 by Microtubule Affinity Regulating Kinases regulates its function in presynaptic protein trafficking.Synaptic alterations in the rTg4510 mouse model of tauopathy.The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers through Tau phosphorylationAttenuation of synaptic toxicity and MARK4/PAR1-mediated Tau phosphorylation by methylene blue for Alzheimer's disease treatment.Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance.Dendritic spines: the locus of structural and functional plasticity.Involvement of 'stress-response' kinase pathways in Alzheimer's disease progression.Protein phosphorylation in neurodegeneration: friend or foe?Endoplasmic reticulum calcium stores in dendritic spinesAβ Influences Cytoskeletal Signaling Cascades with Consequences to Alzheimer's Disease.The myriad roles of Miro in the nervous system: axonal transport of mitochondria and beyond.The Essential Role of Soluble Aβ Oligomers in Alzheimer's Disease.Roles of Calcium Stores and Store-Operated Channels in Plasticity of Dendritic Spines.Liquid-liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau.Cellular and molecular modifier pathways in tauopathies: the big picture from screening invertebrate models.Microtubule affinity-regulating kinases are potential druggable targets for Alzheimer's disease.Candidate gene analysis for Alzheimer's disease in adults with Down syndrome.An acetylation-phosphorylation switch that regulates tau aggregation propensity and function.
P2860
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P2860
A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Aβ on synapses and dendritic spines
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
A critical role for the PAR-1/ ...... synapses and dendritic spines
@ast
A critical role for the PAR-1/ ...... synapses and dendritic spines
@en
type
label
A critical role for the PAR-1/ ...... synapses and dendritic spines
@ast
A critical role for the PAR-1/ ...... synapses and dendritic spines
@en
prefLabel
A critical role for the PAR-1/ ...... synapses and dendritic spines
@ast
A critical role for the PAR-1/ ...... synapses and dendritic spines
@en
P2093
P2860
P50
P356
P1476
A critical role for the PAR-1/ ...... synapses and dendritic spines
@en
P2093
Bingwei Lu
Dhananjay Wagh
Jayakumar Rajadas
P2860
P304
P356
10.1093/HMG/DDR576
P577
2011-12-08T00:00:00Z