Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology.
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Galactic cosmic radiation leads to cognitive impairment and increased aβ plaque accumulation in a mouse model of Alzheimer's diseaseImmunotherapy as treatment for Alzheimer’s diseaseNLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 miceNeural stem/progenitor cells in Alzheimer's diseaseMicroglial Priming and Alzheimer's Disease: A Possible Role for (Early) Immune Challenges and Epigenetics?Targeting innate immunity for neurodegenerative disorders of the central nervous systemRole of pro-inflammatory cytokines released from microglia in Alzheimer's diseaseRodent models of neuroinflammation for Alzheimer's diseaseInnate immunity in Alzheimer's disease: a complex affairAlterations in immune cells and mediators in the brain: it's not always neuroinflammation!Neuroinflammation in Alzheimer's disease; A source of heterogeneity and target for personalized therapyModulation of learning and memory by cytokines: signaling mechanisms and long term consequencesInterleukin-1β protects astrocytes against oxidant-induced injury via an NF-κB-dependent upregulation of glutathione synthesis.Balancing the immune response in the brain: IL-10 and its regulationMechanisms of mononuclear phagocyte recruitment in Alzheimer's diseaseAntidepressants reduce neuroinflammatory responses and astroglial alpha-synuclein accumulation in a transgenic mouse model of multiple system atrophyEffects of specific multi-nutrient enriched diets on cerebral metabolism, cognition and neuropathology in AβPPswe-PS1dE9 miceInflammatory Stress on Autophagy in Peripheral Blood Mononuclear Cells from Patients with Alzheimer's Disease during 24 Months of Follow-UpAmyloid-β-induced astrocytic phagocytosis is mediated by CD36, CD47 and RAGEThe NALP3 inflammasome is involved in the innate immune response to amyloid-betaNeuroprotective and neurotoxic properties of glial cells in the pathogenesis of Alzheimer's diseaseBehavioral, structural and molecular changes following long-term hippocampal IL-1β overexpression in transgenic mice.Sustained hippocampal IL-1beta overexpression impairs contextual and spatial memory in transgenic mice.Alzheimer disease models and human neuropathology: similarities and differencesInhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes.Up-regulation and activation of the P2Y(2) nucleotide receptor mediate neurite extension in IL-1β-treated mouse primary cortical neuronsAmyloid-β induces NLRP1-dependent neuronal pyroptosis in models of Alzheimer's disease.Cross-species evidence for the role of interleukin-33 in depression riskEliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology.Temporal-logic analysis of microglial phenotypic conversion with exposure to amyloid-β.Detailed immunohistochemical characterization of temporal and spatial progression of Alzheimer's disease-related pathologies in male triple-transgenic miceDorsal raphe neuroinflammation promotes dramatic behavioral stress dysregulationIntermittent fasting attenuates lipopolysaccharide-induced neuroinflammation and memory impairment.Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model.Why pleiotropic interventions are needed for Alzheimer's disease.Targeting the endocannabinoid system in Alzheimer's disease.Interleukin-1β mediated amyloid plaque clearance is independent of CCR2 signaling in the APP/PS1 mouse model of Alzheimer's disease.Transition from an M1 to a mixed neuroinflammatory phenotype increases amyloid deposition in APP/PS1 transgenic mice.The role of microglia in human disease: therapeutic tool or target?LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice
P2860
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P2860
Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Sustained hippocampal IL-1 bet ...... es Alzheimer plaque pathology.
@ast
Sustained hippocampal IL-1 bet ...... es Alzheimer plaque pathology.
@en
type
label
Sustained hippocampal IL-1 bet ...... es Alzheimer plaque pathology.
@ast
Sustained hippocampal IL-1 bet ...... es Alzheimer plaque pathology.
@en
prefLabel
Sustained hippocampal IL-1 bet ...... es Alzheimer plaque pathology.
@ast
Sustained hippocampal IL-1 bet ...... es Alzheimer plaque pathology.
@en
P2093
P2860
P921
P356
P1476
Sustained hippocampal IL-1 bet ...... es Alzheimer plaque pathology.
@en
P2093
Jen-nie H Miller
John A Olschowka
M Kerry O'Banion
Renee E Johnson
Solomon S Shaftel
Stephanos Kyrkanides
P2860
P304
P356
10.1172/JCI31450
P407
P577
2007-06-01T00:00:00Z