Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology. - Wikidata - awgldk - TriplyDB

Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology.

Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology.

http://www.wikidata.org/entity/Q35813745

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Galactic cosmic radiation leads to cognitive impairment and increased aβ plaque accumulation in a mouse model of Alzheimer's disease Immunotherapy as treatment for Alzheimer’s disease NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice Neural stem/progenitor cells in Alzheimer's disease Microglial Priming and Alzheimer's Disease: A Possible Role for (Early) Immune Challenges and Epigenetics?Targeting innate immunity for neurodegenerative disorders of the central nervous system Role of pro-inflammatory cytokines released from microglia in Alzheimer's disease Rodent models of neuroinflammation for Alzheimer's disease Innate immunity in Alzheimer's disease: a complex affair Alterations in immune cells and mediators in the brain: it's not always neuroinflammation!Neuroinflammation in Alzheimer's disease; A source of heterogeneity and target for personalized therapy Modulation of learning and memory by cytokines: signaling mechanisms and long term consequences Interleukin-1β protects astrocytes against oxidant-induced injury via an NF-κB-dependent upregulation of glutathione synthesis.Balancing the immune response in the brain: IL-10 and its regulation Mechanisms of mononuclear phagocyte recruitment in Alzheimer's disease Antidepressants reduce neuroinflammatory responses and astroglial alpha-synuclein accumulation in a transgenic mouse model of multiple system atrophy Effects of specific multi-nutrient enriched diets on cerebral metabolism, cognition and neuropathology in AβPPswe-PS1dE9 mice Inflammatory Stress on Autophagy in Peripheral Blood Mononuclear Cells from Patients with Alzheimer's Disease during 24 Months of Follow-Up Amyloid-β-induced astrocytic phagocytosis is mediated by CD36, CD47 and RAGE The NALP3 inflammasome is involved in the innate immune response to amyloid-beta Neuroprotective and neurotoxic properties of glial cells in the pathogenesis of Alzheimer's disease Behavioral, structural and molecular changes following long-term hippocampal IL-1β overexpression in transgenic mice.Sustained hippocampal IL-1beta overexpression impairs contextual and spatial memory in transgenic mice.Alzheimer disease models and human neuropathology: similarities and differences Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes.Up-regulation and activation of the P2Y(2) nucleotide receptor mediate neurite extension in IL-1β-treated mouse primary cortical neurons Amyloid-β induces NLRP1-dependent neuronal pyroptosis in models of Alzheimer's disease.Cross-species evidence for the role of interleukin-33 in depression risk Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology.Temporal-logic analysis of microglial phenotypic conversion with exposure to amyloid-β.Detailed immunohistochemical characterization of temporal and spatial progression of Alzheimer's disease-related pathologies in male triple-transgenic mice Dorsal raphe neuroinflammation promotes dramatic behavioral stress dysregulation Intermittent fasting attenuates lipopolysaccharide-induced neuroinflammation and memory impairment.Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model.Why pleiotropic interventions are needed for Alzheimer's disease.Targeting the endocannabinoid system in Alzheimer's disease.Interleukin-1β mediated amyloid plaque clearance is independent of CCR2 signaling in the APP/PS1 mouse model of Alzheimer's disease.Transition from an M1 to a mixed neuroinflammatory phenotype increases amyloid deposition in APP/PS1 transgenic mice.The role of microglia in human disease: therapeutic tool or target?LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice

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P2860

Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology.

http://www.wikidata.org/entity/Q35813745

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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2007年论文

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name

Sustained hippocampal IL-1 bet ...... es Alzheimer plaque pathology.

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Sustained hippocampal IL-1 bet ...... es Alzheimer plaque pathology.

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type

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Sustained hippocampal IL-1 bet ...... es Alzheimer plaque pathology.

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Sustained hippocampal IL-1 bet ...... es Alzheimer plaque pathology.

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Sustained hippocampal IL-1 bet ...... es Alzheimer plaque pathology.

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Sustained hippocampal IL-1 bet ...... es Alzheimer plaque pathology.

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Journal of Clinical Investigation

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Sustained hippocampal IL-1 bet ...... es Alzheimer plaque pathology.

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Jen-nie H Miller

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John A Olschowka

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M Kerry O'Banion

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Renee E Johnson

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Solomon S Shaftel

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Stephanos Kyrkanides

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P2860

Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus

Transcriptional and posttranslational regulation of Cre recombinase by RU486 as the basis for an enhanced inducible expression system

Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase

Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database

Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells.

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease

Microglial chemotaxis, activation, and phagocytosis of amyloid beta-peptide as linked phenomena in Alzheimer's disease.

Interleukin-1 mediates Alzheimer and Lewy body pathologies.

Microglia and inflammatory mechanisms in the clearance of amyloid beta peptide.

Neuroinflammation and anti-inflammatory therapy for Alzheimer's disease.

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1595-1604

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10.1172/JCI31450

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6

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117

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17549256

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Alzheimer's disease

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1878531

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