Defective double-strand DNA break repair and chromosomal translocations by MYC overexpression. - Wikidata - awgldk - TriplyDB

Defective double-strand DNA break repair and chromosomal translocations by MYC overexpression.

Defective double-strand DNA break repair and chromosomal translocations by MYC overexpression.

http://www.wikidata.org/entity/Q35814896

about

MYC activation is a hallmark of cancer initiation and maintenance c-Myc accelerates S-phase and requires WRN to avoid replication stress Inhibitory effect of c-Myc on p53-induced apoptosis in leukemia cells. Microarray analysis reveals defective induction of p53 target genes and upregulation of chaperone genes Mutation in Rpa1 results in defective DNA double-strand break repair, chromosomal instability and cancer in mice MYC on the path to cancer Myc is required for activation of the ATM-dependent checkpoints in response to DNA damage c-MYC-Making Liver Sick: Role of c-MYC in Hepatic Cell Function, Homeostasis and Disease.Estrogen receptor β induces antiinflammatory and antitumorigenic networks in colon cancer cells.Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model The DNA double-strand break response is abnormal in myeloblasts from patients with therapy-related acute myeloid leukemia.Multi-gene fluorescence in situ hybridization to detect cell cycle gene copy number aberrations in young breast cancer patients.Inactivation of MYC reverses tumorigenesis.The Dual Roles of MYC in Genomic Instability and Cancer Chemoresistance c-Myc induces chromosomal rearrangements through telomere and chromosome remodeling in the interphase nucleus.Cdc6 cooperates with c-Myc to promote genome instability and epithelial to mesenchymal transition EMT in zebrafish.MYC Inactivation Elicits Oncogene Addiction through Both Tumor Cell-Intrinsic and Host-Dependent Mechanisms.Prostaglandin F2α: a bone remodeling mediator.Homologous recombination DNA repair genes play a critical role in reprogramming to a pluripotent state.Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformation.CSN6 drives carcinogenesis by positively regulating Myc stability.The G1 phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification.Regulation of the cellular DNA double-strand break response.Identification of synthetic lethality of PRKDC in MYC-dependent human cancers by pooled shRNA screening.MYC is a critical target of FBXW7 Dysregulated TCL1 requires the germinal center and genome instability for mature B-cell transformation.c-Myc-dependent formation of Robertsonian translocation chromosomes in mouse cells.c-Myc suppression of DNA double-strand break repair.A quantitative PCR method to detect blood microRNAs associated with tumorigenesis in transgenic mice.The mystery of chromosomal translocations in cancer.Induction of Chromosomal Instability via Telomere Dysfunction and Epigenetic Alterations in Myeloid Neoplasia Cdc45 is a critical effector of myc-dependent DNA replication stress.Histone H2AX suppresses translocations in lymphomas of Eμ-c-Myc transgenic mice that contain a germline amplicon of tumor-promoting genes Low-fidelity compensatory backup alternative DNA repair pathways may unify current carcinogenesis theories.Family matters: How MYC family oncogenes impact small cell lung cancer.A novel alkylating agent Melflufen induces irreversible DNA damage and cytotoxicity in multiple myeloma cells Bcl2 suppresses DNA repair by enhancing c-Myc transcriptional activity.Essential roles of Caspase-3 in facilitating Myc-induced genetic instability and carcinogenesis.c-MYC-induced genomic instability.Hepatitis C virus-induced activation of β-catenin promotes c-Myc expression and a cascade of pro-carcinogenetic events.Programming of Cell Resistance to Genotoxic and Oxidative Stress.

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P2860

Defective double-strand DNA break repair and chromosomal translocations by MYC overexpression.

http://www.wikidata.org/entity/Q35814896

description

2003 nî lūn-bûn

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Defective double-strand DNA br ...... cations by MYC overexpression.

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Defective double-strand DNA br ...... cations by MYC overexpression.

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Defective double-strand DNA br ...... cations by MYC overexpression.

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Defective double-strand DNA br ...... cations by MYC overexpression.

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Proceedings of the National Academy of Sciences of the United States of America

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Defective double-strand DNA br ...... cations by MYC overexpression.

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Asa Karlsson

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Dean W Felsher

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Debabrita Deb-Basu

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Stephanie Turner

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P2860

Overexpression of MYC causes p53-dependent G2 arrest of normal fibroblasts

XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

Megabase chromatin domains involved in DNA double-strand breaks in vivo

The DNA damage response: putting checkpoints in perspective

The Myc/Max/Mad network and the transcriptional control of cell behavior

Proliferation, cell cycle and apoptosis in cancer

DNA double-strand breaks: signaling, repair and the cancer connection

Hus1 acts upstream of chk1 in a mammalian DNA damage response pathway

Myc suppresses induction of the growth arrest genes gadd34, gadd45, and gadd153 by DNA-damaging agents

Characterization of the c-MYC-regulated transcriptome by SAGE: identification and analysis of c-MYC target genes

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