MDM2 inhibits p300-mediated p53 acetylation and activation by forming a ternary complex with the two proteins.
about
Coordinated regulation of p53 apoptotic targets BAX and PUMA by SMAR1 through an identical MAR elementNegative regulation of p53 functions by Daxx and the involvement of MDM2Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligaseMDM2-HDAC1-mediated deacetylation of p53 is required for its degradationRibosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibitionCooperative regulation of p53 by modulation of ternary complex formation with CBP/p300 and HDM2Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53Hepatitis C Virus Impairs p53 via Persistent Overexpression of 3 -Hydroxysterol 24-ReductaseStructure of the Taz2 domain of p300: insights into ligand bindingp53 Acetylation: Regulation and ConsequencesMDM2 inhibits PCAF (p300/CREB-binding protein-associated factor)-mediated p53 acetylationActivation and activities of the p53 tumour suppressor proteinActivation of p53 by nutlin-3a induces apoptosis and cellular senescence in human glioblastoma multiformeTherapeutic considerations for Mdm2: not just a one trick ponyC-terminal ubiquitination of p53 contributes to nuclear exportCombining Oncolytic Virotherapy with p53 Tumor Suppressor Gene TherapyPIG3 Regulates p53 Stability by Suppressing Its MDM2-Mediated UbiquitinationAge-related susceptibility to apoptosis in human retinal pigment epithelial cells is triggered by disruption of p53-Mdm2 association.MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation.MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional outputMdm2 RING mutation enhances p53 transcriptional activity and p53-p300 interaction.SIRT1 confers protection against UVB- and H2O2-induced cell death via modulation of p53 and JNK in cultured skin keratinocytes.The dynamics of stress p53-Mdm2 network regulated by p300 and HDAC1.A small nuclear RNA, hdm365, is the major processing product of the human mdm2 gene.Zinc Finger 280B regulates sGCα1 and p53 in prostate cancer cellsAnalysing p53 tumour suppressor functions in mice.Regulation of p53 responses by post-translational modifications.The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases.A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53.Inauhzin and Nutlin3 synergistically activate p53 and suppress tumor growthGene and protein analysis reveals that p53 pathway is functionally inactivated in cytogenetically normal Acute Myeloid Leukemia and Acute Promyelocytic LeukemiaYY1 is a novel potential therapeutic target for the treatment of HPV infection-induced cervical cancer by arsenic trioxide.Dual Roles of MDM2 in the Regulation of p53: Ubiquitination Dependent and Ubiquitination Independent Mechanisms of MDM2 Repression of p53 Activity.Inauhzin sensitizes p53-dependent cytotoxicity and tumor suppression of chemotherapeutic agents.Molecular approaches to sarcoma therapy.Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation.Targeting HPV16 E6-p300 interaction reactivates p53 and inhibits the tumorigenicity of HPV-positive head and neck squamous cell carcinoma.Regulation of p53--insights into a complex process.Mdm2 and MdmX as Regulators of Gene ExpressionTargeting the ubiquitin-mediated proteasome degradation of p53 for cancer therapy.
P2860
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P2860
MDM2 inhibits p300-mediated p53 acetylation and activation by forming a ternary complex with the two proteins.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
MDM2 inhibits p300-mediated p5 ...... complex with the two proteins.
@ast
MDM2 inhibits p300-mediated p5 ...... complex with the two proteins.
@en
type
label
MDM2 inhibits p300-mediated p5 ...... complex with the two proteins.
@ast
MDM2 inhibits p300-mediated p5 ...... complex with the two proteins.
@en
prefLabel
MDM2 inhibits p300-mediated p5 ...... complex with the two proteins.
@ast
MDM2 inhibits p300-mediated p5 ...... complex with the two proteins.
@en
P2093
P2860
P356
P1476
MDM2 inhibits p300-mediated p5 ...... complex with the two proteins.
@en
P2093
P2860
P304
12547-12552
P356
10.1073/PNAS.97.23.12547
P407
P577
2000-11-01T00:00:00Z