Cell type-specific inhibition of p53-mediated apoptosis by mdm2.
about
The Mdm2 oncoprotein interacts with the cell fate regulator NumbExpression of the papillomavirus E2 protein in HeLa cells leads to apoptosisThe requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression.Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulationMDM2 suppresses p73 function without promoting p73 degradationRegulation of p53 function and stability by phosphorylationInhibition of N-terminal lysines acetylation and transcription factor assembly by epirubicin induced deranged cell homeostasisA novel p53-inducible gene, PAG608, encodes a nuclear zinc finger protein whose overexpression promotes apoptosisKinetics of p53 binding to promoter sites in vivo.Mdm2: the ups and downs.Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis.The E7 oncoprotein of human papillomavirus type 16 stabilizes p53 through a mechanism independent of p19(ARF).Regulation of Mdm2-directed degradation by the C terminus of p53.The human oncoprotein MDM2 arrests the cell cycle: elimination of its cell-cycle-inhibitory function induces tumorigenesisProteasomal degradation of p53 by human papillomavirus E6 oncoprotein relies on the structural integrity of p53 core domain.Human papillomavirus oncoproteins E6 and E7 independently abrogate the mitotic spindle checkpoint.A functional polymorphism T309G in MDM2 gene promoter, intensified by Helicobacter pylori lipopolysaccharide, is associated with both an increased susceptibility and poor prognosis of gastric carcinoma in Chinese patients.Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells.Protective effect of the silkworm protein 30Kc6 on human vascular endothelial cells damaged by oxidized low density lipoprotein (Ox-LDL).Suppression of the p300-dependent mdm2 negative-feedback loop induces the p53 apoptotic function.Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study.A repertoire of cell cycle regulators whose expression is coordinated with human cytotrophoblast differentiationThe presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability.High levels of Hdmx promote cell growth in a subset of uveal melanomas.Effects of p53 mutants derived from lung carcinomas on the p53-responsive element (p53RE) of the MDM2 gene.HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53.Transcription abnormalities potentiate apoptosis of normal human fibroblasts.Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function.Proteolytic cleavage of human p53 by calpain: a potential regulator of protein stability.Constitutive activation of gene expression by thyroid hormone receptor results from reversal of p53-mediated repression.SAR405838: A Novel and Potent Inhibitor of the MDM2:p53 Axis for the Treatment of Dedifferentiated Liposarcoma.Reactivation of p53 by novel MDM2 inhibitors: implications for pancreatic cancer therapy.Analysis of Ki67, HMGA1, MDM2, and RB expression in nonfunctioning pituitary adenomas.Oncogenic functions of hMDMX in in vitro transformation of primary human fibroblasts and embryonic retinoblasts.HIV-1 Tat potently stabilises Mdm2 and enhances viral replication.Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis.The double benefit of Spalax p53: surviving underground hypoxia while defying lung cancer cells in vitro via autophagy and caspase-dependent cell deathc-Abl regulates p53 levels under normal and stress conditions by preventing its nuclear export and ubiquitinationDown-regulation of beta-catenin by activated p53.Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitination.
P2860
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P2860
Cell type-specific inhibition of p53-mediated apoptosis by mdm2.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Cell type-specific inhibition of p53-mediated apoptosis by mdm2.
@ast
Cell type-specific inhibition of p53-mediated apoptosis by mdm2.
@en
type
label
Cell type-specific inhibition of p53-mediated apoptosis by mdm2.
@ast
Cell type-specific inhibition of p53-mediated apoptosis by mdm2.
@en
prefLabel
Cell type-specific inhibition of p53-mediated apoptosis by mdm2.
@ast
Cell type-specific inhibition of p53-mediated apoptosis by mdm2.
@en
P2093
P2860
P1433
P1476
Cell type-specific inhibition of p53-mediated apoptosis by mdm2.
@en
P2093
P2860
P304
P407
P577
1996-04-01T00:00:00Z