Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function.
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The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression.Inhibition of cell proliferation, induction of apoptosis, reactivation of DLC1, and modulation of other gene expression by dietary flavone in breast cancer cell linesFunctional promoter upstream p53 regulatory sequence of IGFBP3 that is silenced by tumor specific methylationClinical Overview of MDM2/X-Targeted TherapiesNuclear actions of insulin-like growth factor binding protein-3A ribonucleotide reductase gene is a transcriptional target of p53 and p73Role of insulin-like growth factor binding protein-3 in breast cancer cell growthASPP [corrected] and cancerA novel p53-inducible gene, PAG608, encodes a nuclear zinc finger protein whose overexpression promotes apoptosisCluster Analysis of p53 Binding Site Sequences Reveals Subsets with Different Functions.Functional mutants of the sequence-specific transcription factor p53 and implications for master genes of diversityBiological characterization of two xenografts derived from human CUPs (carcinomas of unknown primary).Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancerp73 competes with p53 and attenuates its response in a human ovarian cancer cell line.Insights into cancer from transgenic mouse models.Mouse models of p53 functions.Characterization of structural p53 mutants which show selective defects in apoptosis but not cell cycle arrestmdm2: a bridge over the two tumour suppressors, p53 and Rb.Role of p53 family members in apoptosis.Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis.p53-mediated repression of alpha-fetoprotein gene expression by specific DNA binding.Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo.p53-dependent senescence delays Emu-myc-induced B-cell lymphomagenesis.Mechanisms of regulatory diversity within the p53 transcriptional network.p53-Dependent and p53-independent induction of insulin-like growth factor binding protein-3 by deoxyribonucleic acid damage and hypoxia.Mutant p53 exerts a dominant negative effect by preventing wild-type p53 from binding to the promoter of its target genes.Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence.Crippling p53 activities via knock-in mutations in mouse models.Disparate chromatin landscapes and kinetics of inactivation impact differential regulation of p53 target genesDysregulation of apoptosis and a novel mechanism of defective apoptotic signal transduction in human B-cell neoplasms.E2 proteins from high- and low-risk human papillomavirus types differ in their ability to bind p53 and induce apoptotic cell death.Apoptosis is the essential target of selective pressure against p53, whereas loss of additional p53 functions facilitates carcinoma progression.Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53p21 delays tumor onset by preservation of chromosomal stability.Enforced expression of PPP1R13L increases tumorigenesis and invasion through p53-dependent and p53-independent mechanisms.Cancer therapeutic approach based on conformational stabilization of mutant p53 protein by small peptides.The tumor suppressor gene TP53: implications for cancer management and therapy.What have animal models taught us about the p53 pathway?Transcriptional functionality of germ line p53 mutants influences cancer phenotype.Gene-specific mechanisms of p53 transcriptional control and prospects for cancer therapy.
P2860
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P2860
Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Differential activation of tar ...... h impaired apoptotic function.
@ast
Differential activation of tar ...... h impaired apoptotic function.
@en
type
label
Differential activation of tar ...... h impaired apoptotic function.
@ast
Differential activation of tar ...... h impaired apoptotic function.
@en
prefLabel
Differential activation of tar ...... h impaired apoptotic function.
@ast
Differential activation of tar ...... h impaired apoptotic function.
@en
P2093
P2860
P356
P1476
Differential activation of tar ...... h impaired apoptotic function.
@en
P2093
P2860
P304
P356
10.1128/MCB.16.9.4952
P407
P577
1996-09-01T00:00:00Z