Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions - Wikidata - awgldk - TriplyDB

Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions

Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions

http://www.wikidata.org/entity/Q35869898

about

The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection Chemotherapeutic compounds targeting the DNA double-strand break repair pathways: the good, the bad, and the promising DNA double-strand break repair pathway choice and cancer Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site The tail that wags the dog: p12, the smallest subunit of DNA polymerase δ, is degraded by ubiquitin ligases in response to DNA damage and during cell cycle progression Potentially functional SNPs (pfSNPs) as novel genomic predictors of 5-FU response in metastatic colorectal cancer patients Exonuclease 1 is a critical mediator of survival during DNA double strand break repair in nonquiescent hematopoietic stem and progenitor cells.FOXM1 modulates cisplatin sensitivity by regulating EXO1 in ovarian cancer PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways.Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice.A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy.Immunofluorescence-based methods to monitor DNA end resection.End resection at double-strand breaks: mechanism and regulation.DNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA end resection in human cells RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks.Differential contribution of HP1 proteins to DNA end resection and homology-directed repair.PARP1-driven poly-ADP-ribosylation regulates BRCA1 function in homologous recombination-mediated DNA repair.The role of ATM in the deficiency in nonhomologous end-joining near telomeres in a human cancer cell line.Human RECQ1 interacts with Ku70/80 and modulates DNA end-joining of double-strand breaks BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres DNA end resection is needed for the repair of complex lesions in G1-phase human cells.DNA double-strand break repair is impaired in presenescent Syrian hamster fibroblasts Single-molecule imaging reveals the mechanism of Exo1 regulation by single-stranded DNA binding proteins.EXO1 is critical for embryogenesis and the DNA damage response in mice with a hypomorphic Nbs1 allele.Impact of Charged Particle Exposure on Homologous DNA Double-Strand Break Repair in Human Blood-Derived Cells.Mechanisms of telomere loss and their consequences for chromosome instability.Processing by MRE11 is involved in the sensitivity of subtelomeric regions to DNA double-strand breaks.Exonuclease 1 (Exo1) is required for activating response to S(N)1 DNA methylating agents.Distinct functions of human RECQ helicases WRN and BLM in replication fork recovery and progression after hydroxyurea-induced stalling.Identification of RNF8 as a ubiquitin ligase involved in targeting the p12 subunit of DNA polymerase δ for degradation in response to DNA damage Artemis is required to improve the accuracy of repair of double-strand breaks with 5'-blocked termini generated from non-DSB-clustered lesions.Controlling DNA-end resection: a new task for CDKs.BRCA1 in the DNA damage response and at telomeres Sharpening the ends for repair: mechanisms and regulation of DNA resection.Mechanism and regulation of DNA end resection in eukaryotes CDK1 phosphorylates WRN at collapsed replication forks.Human DNA2 possesses a cryptic DNA unwinding activity that functionally integrates with BLM or WRN helicases.PCNA promotes processive DNA end resection by Exo1.The MutSβ complex is a modulator of p53-driven tumorigenesis through its functions in both DNA double-strand break repair and mismatch repair CD133+ cells contribute to radioresistance via altered regulation of DNA repair genes in human lung cancer cells.

P2860

Q24298401-A05E8747-F0EA-4CE0-8FCE-985BD9A23BFB Q26863501-18E2CA1C-10AC-436A-B291-73A026B169FE Q26996175-EB7E1633-96AF-4933-A1C7-50C83F626143 Q27727694-5B03905C-22B3-4846-9926-5E55DE56C993 Q28303222-52C0ACB4-EAF4-4E5F-BFE6-A1000E297049 Q28544740-5E65CAD0-DDF4-43F1-AF71-E8F5CBF4FCA6 Q33573646-92642F67-809A-47C1-91DB-B8B32D3AAD2B Q33605013-A7DA42DC-E289-4386-8172-56C120B35639 Q33635465-790A37CA-FC04-49C6-8894-B1DB3519F319 Q33697447-7A522AF3-C15F-4515-A7FA-93EB5DB8AAD4 Q33698648-E85EA524-5134-4286-A691-4834A2726A47 Q33828763-74BD9D06-D2E1-4DC3-9F5A-648E07C14D70 Q33938581-76AC9FAA-11A4-409A-B2BF-322927EF88FA Q34245155-390855C6-0724-4669-9833-F0A8423165EC Q34531343-8AEC4600-EEE8-46A6-B706-4A9358C8DF76 Q34536140-2ED2D573-DDC2-4400-9171-7E2B8FFF0C70 Q34644116-BD43DE01-EE09-4F28-BE61-FA8468595FDD Q34649915-ACD62CC3-041C-487C-A352-C7665C984EC6 Q34708378-2F3FD450-847C-4F19-B118-2439D237F92F Q35116646-602AB271-A339-4B55-ACED-F4D649AAF061 Q35500045-63FAE690-B8C5-472C-B2A5-D4AA340AF501 Q35803657-0FABCB1D-0544-4221-8CCC-AE1432B46B09 Q35925569-745EE252-9752-4652-8838-921D398A9EF1 Q36002464-E21A18FA-A97C-4769-9E98-3E2D58693467 Q36270627-78D2AA42-7BFB-4069-A077-922B7650D391 Q36296137-59457F17-33B3-4656-9214-B2C0C5DB80D3 Q36299151-D57FE3D6-D941-443B-9285-4F5B86EF570E Q36421123-CD547790-7679-4968-9805-ED1FE846CB78 Q36553152-4FC24B64-3C3C-4B77-9EB9-091DB6813282 Q36579431-D44B4CCC-BF80-4451-AC81-94FC37F46938 Q36778971-27AD4410-F525-4C70-B33D-798382E176C0 Q36893881-6A6EC600-9354-43C8-86FD-01FB5270A7CF Q36945848-54313741-8D84-4561-B853-E022080AC74F Q37058602-4255C0B8-38F4-49C7-AD16-2A853964CF9A Q37118849-F3B0BDAA-A840-4677-91B6-DEDBA61E64B7 Q37266260-6CA86B0B-FE32-4B50-A38C-37DC805D606D Q37270358-7B9F0CB4-B43E-4CC9-9A18-F9C0D118AF85 Q37271214-EF4A4881-B9A0-46FB-9F8B-30192F73D46A Q37653026-4BEBD893-C7EF-472C-8B83-3E9B1CEAC1EF Q37732341-02853A24-B11E-474B-A2AF-2008EBB921BE

P2860

Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions

http://www.wikidata.org/entity/Q35869898

description

2012 nî lūn-bûn

@nan

2012年の論文

@ja

2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

2012年论文

@zh

2012年论文

@zh-cn

name

Exo1 plays a major role in DNA ...... and damage signaling decisions

@ast

Exo1 plays a major role in DNA ...... and damage signaling decisions

@en

type

label

Exo1 plays a major role in DNA ...... and damage signaling decisions

@ast

Exo1 plays a major role in DNA ...... and damage signaling decisions

@en

prefLabel

Exo1 plays a major role in DNA ...... and damage signaling decisions

@ast

Exo1 plays a major role in DNA ...... and damage signaling decisions

@en

P1433

Q35869898-EE571D98-2E77-43EC-B6B4-07D468D3FBDD

P1476

Q35869898-5F6B4E3A-41A9-4CE6-9214-35F8CD734029

P2093

Q35869898-0CF22F74-AA83-4153-A46B-88DABB724328

Q35869898-0FEB03C2-2D2C-49EA-9FBD-AE99AC908DBF

Q35869898-1949B556-C183-4647-B107-5198F93A5F7E

Q35869898-6F903E9F-12A5-465E-B245-62EDC5D94BB3

Q35869898-A54C336E-A61D-47FF-B408-0CAC852F6F02

Q35869898-E45FAE5E-1F5E-4FE3-A8E6-805114F90F7C

P2860

Q35869898-09700B83-46C0-44C0-BC82-97D41CD1F3E8

Q35869898-18066DDD-E1C7-4FE5-A0FE-9C6CD36376A2

Q35869898-199847C1-5BE0-4F30-AF1F-AE74CD5CF89F

Q35869898-1DD9471A-633A-45D2-B918-FD23472F6615

Q35869898-22BAA2EF-E87A-483A-BAA9-8F75A46C84B8

Q35869898-30F63825-1A8F-4CFE-B1BD-EE7CECDC569D

Q35869898-31420371-1C97-48BF-AAAA-41507A0D8EAE

Q35869898-32423E86-E5AE-41DF-90F6-4F65AEFA0E85

Q35869898-32B97E1C-CF06-4116-995D-B10B8FEA47B0

Q35869898-3404F28B-29C0-4507-854A-C8C5096C776E

P304

Q35869898-8B8F6446-C5EF-4E4F-9D9B-F9EDBF016B1A

P31

Q35869898-BEF2BE0A-54CF-4628-AFB1-7288E4666275

P356

Q35869898-2EB25946-AEE7-49D2-9188-52588F5A8263

P433

Q35869898-EC86F092-CCFD-4809-A2C3-B0D9B6356BA4

P478

Q35869898-6588F83D-C652-43B5-A50F-ECA85187B1FE

P50

Q35869898-A6754AEA-E139-47F1-A748-9FA96207BD93

P577

Q35869898-FC1B9BFC-6269-458B-9DA5-92159C3F3769

P5875

Q35869898-47DAEC5A-06C9-4D53-9162-CC2C1B6D4344

P698

Q35869898-1B20B167-B043-4814-8304-E122DD05F77D

P932

Q35869898-D71134A4-1A55-447E-AC79-569F8C62BB6E

P356

J.DNAREP.2012.01.006

P1433

P1476

Exo1 plays a major role in DNA ...... and damage signaling decisions

@en

P2093

Akihiro Kurimasa

http://www.w3.org/2001/XMLSchema#string

Bipasha Mukherjee

http://www.w3.org/2001/XMLSchema#string

Katherine Deland

http://www.w3.org/2001/XMLSchema#string

Kum Kum Khanna

http://www.w3.org/2001/XMLSchema#string

Nozomi Tomimatsu

http://www.w3.org/2001/XMLSchema#string

Sandeep Burma

http://www.w3.org/2001/XMLSchema#string

P2860

BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair

Ku recruits XLF to DNA double-strand breaks

DNA end resection by CtIP and exonuclease 1 prevents genomic instability

CDK targets Sae2 to control DNA-end resection and homologous recombination

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

DNA resection in eukaryotes: deciding how to fix the break

Human CtIP promotes DNA end resection

DNA end resection: many nucleases make light work

Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair

P304

441-448

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1016/J.DNAREP.2012.01.006

http://www.w3.org/2001/XMLSchema#string

P433

4

http://www.w3.org/2001/XMLSchema#string

P478

11

http://www.w3.org/2001/XMLSchema#string

P50

P577

2012-02-11T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

221824714

http://www.w3.org/2001/XMLSchema#string

P698

22326273

http://www.w3.org/2001/XMLSchema#string

P932

3319278

http://www.w3.org/2001/XMLSchema#string