Ubiquitylation and proteasomal degradation of the p21(Cip1), p27(Kip1) and p57(Kip2) CDK inhibitors
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Translational Upregulation of an Individual p21Cip1 Transcript Variant by GCN2 Regulates Cell Proliferation and Survival under Nutrient StressA NIK-IKKα module expands ErbB2-induced tumor-initiating cells by stimulating nuclear export of p27/Kip1N-Terminal Acetylation-Targeted N-End Rule Proteolytic System: The Ac/N-End Rule PathwayCurrent topics of functional links between primary cilia and cell cycleCathepsin B promotes colorectal tumorigenesis, cell invasion, and metastasisP21-activated kinase 4 regulates the cyclin-dependent kinase inhibitor p57(kip2) in human breast cancerNeurofibromatosis type 2 tumor suppressor protein, NF2, induces proteasome-mediated degradation of JC virus T-antigen in human glioblastomaPCTAIRE1 phosphorylates p27 and regulates mitosis in cancer cells.miR-221 promotes tumorigenesis in human triple negative breast cancer cells.CRL4BDCAF11 E3 ligase targets p21 for degradation to control cell cycle progression in human osteosarcoma cellsInhibitor of differentiation 4 (ID4) inactivation promotes de novo steroidogenesis and castration-resistant prostate cancer.Cell cycle-related genes p57kip2, Cdk5 and Spin in the pathogenesis of neural tube defects.Basal p21 controls population heterogeneity in cycling and quiescent cell cycle states.VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cellsPKM2 phosphorylates MLC2 and regulates cytokinesis of tumour cells.SKP2 oncogene is a direct MYC target gene and MYC down-regulates p27(KIP1) through SKP2 in human leukemia cells.MAPK signaling pathway regulates p27 phosphorylation at threonin 187 as part of the mechanism triggered by early-weaning to induce cell proliferation in rat gastric mucosa.Increased protein stability of CDKN1C causes a gain-of-function phenotype in patients with IMAGe syndromePolycomb protein SCML2 regulates the cell cycle by binding and modulating CDK/CYCLIN/p21 complexes.Transforming growth factor β1 increases p27 levels via synthesis and degradation mechanisms in the hyperproliferative gastric epithelium in rats.The scaffolding protein EBP50 promotes vascular smooth muscle cell proliferation and neointima formation by regulating Skp2 and p21(cip1).The 26S proteasome complex: an attractive target for cancer therapyCrude extract of Euphorbia formosana induces apoptosis of DU145 human prostate cancer cells acts through the caspase-dependent and independent signaling pathway.Lupeol Induces Apoptosis and Cell Cycle Arrest of Human Osteosarcoma Cells Through PI3K/AKT/mTOR Pathway.High Skp2/Low p57(Kip2) Expression is Associated with Poor Prognosis in Human Breast Carcinoma.FOXM1 is overexpressed in B-acute lymphoblastic leukemia (B-ALL) and its inhibition sensitizes B-ALL cells to chemotherapeutic drugsPromising pharmacological profile of a Kunitz-type inhibitor in murine renal cell carcinoma modelThe histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathwaysThe deubiquitylase USP37 links REST to the control of p27 stability and cell proliferationOmics for prediction of environmental health effects: Blood leukocyte-based cross-omic profiling reliably predicts diseases associated with tobacco smokingLoss of p27Kip¹ promotes metaplasia in the pancreas via the regulation of Sox9 expressionUnfolded-protein response-associated stabilization of p27(Cdkn1b) interferes with lens fiber cell denucleation, leading to cataractStabilization of p21 (Cip1/WAF1) following Tip60-dependent acetylation is required for p21-mediated DNA damage responseAkt destabilizes p57 (Kip2) : Akt at the converging crossroad?The Proteasome Ubiquitin Receptor hRpn13 and Its Interacting Deubiquitinating Enzyme Uch37 Are Required for Proper Cell Cycle ProgressionControl of Trx1 redox state modulates protection against methyl methanesulfonate-induced DNA damage via stabilization of p21.CASZ1 inhibits cell cycle progression in neuroblastoma by restoring pRb activityRNF115/BCA2 E3 ubiquitin ligase promotes breast cancer cell proliferation through targeting p21Waf1/Cip1 for ubiquitin-mediated degradation.TLE3 represses colorectal cancer proliferation by inhibiting MAPK and AKT signaling pathways.SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression.
P2860
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P2860
Ubiquitylation and proteasomal degradation of the p21(Cip1), p27(Kip1) and p57(Kip2) CDK inhibitors
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Ubiquitylation and proteasomal ...... ) and p57(Kip2) CDK inhibitors
@ast
Ubiquitylation and proteasomal ...... ) and p57(Kip2) CDK inhibitors
@en
type
label
Ubiquitylation and proteasomal ...... ) and p57(Kip2) CDK inhibitors
@ast
Ubiquitylation and proteasomal ...... ) and p57(Kip2) CDK inhibitors
@en
prefLabel
Ubiquitylation and proteasomal ...... ) and p57(Kip2) CDK inhibitors
@ast
Ubiquitylation and proteasomal ...... ) and p57(Kip2) CDK inhibitors
@en
P2860
P356
P1433
P1476
Ubiquitylation and proteasomal ...... ) and p57(Kip2) CDK inhibitors
@en
P2093
Tony Hunter
P2860
P304
P356
10.4161/CC.9.12.11988
P577
2010-06-15T00:00:00Z