Stable reduction of CCR5 by RNAi through hematopoietic stem cell transplant in non-human primates. - Wikidata - awgldk - TriplyDB

Stable reduction of CCR5 by RNAi through hematopoietic stem cell transplant in non-human primates.

Stable reduction of CCR5 by RNAi through hematopoietic stem cell transplant in non-human primates.

http://www.wikidata.org/entity/Q35928777

about

Engineering HIV-1-resistant T-cells from short-hairpin RNA-expressing hematopoietic stem/progenitor cells in humanized BLT mice Controlling HIV-1: Non-Coding RNA Gene Therapy Approaches to a Functional Cure Lipid nanoparticles as carriers for RNAi against viral infections: current status and future perspectives Combinatorial RNA-based gene therapy for the treatment of HIV/AIDS Engineering T Cells to Functionally Cure HIV-1 Infection Regulation of haeme oxygenase-1 for treatment of neuroinflammation and brain disorders Survival of the fittest: positive selection of CD4+ T cells expressing a membrane-bound fusion inhibitor following HIV-1 infection Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver Characterization of a potent non-cytotoxic shRNA directed to the HIV-1 co-receptor CCR5.Dynamics of HSPC repopulation in nonhuman primates revealed by a decade-long clonal-tracking study.High-throughput screening of effective siRNAs using luciferase-linked chimeric mRNA Preintegration HIV-1 inhibition by a combination lentiviral vector containing a chimeric TRIM5 alpha protein, a CCR5 shRNA, and a TAR decoy.Live cell monitoring of hiPSC generation and differentiation using differential expression of endogenous microRNAs.Computational models of HIV-1 resistance to gene therapy elucidate therapy design principles A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model.RNAi-mediated CCR5 silencing by LFA-1-targeted nanoparticles prevents HIV infection in BLT mice Methodology and software to detect viral integration site hot-spots.Large animal models of hematopoietic stem cell gene therapy.Transmembrane protein aptamers that inhibit CCR5 expression and HIV coreceptor function Stem cell-based anti-HIV gene therapy.Inhibition of HIV-1 infection by a unique short hairpin RNA to chemokine receptor 5 delivered into macrophages through hematopoietic progenitor cell transduction Foamy combinatorial anti-HIV vectors with MGMTP140K potently inhibit HIV-1 and SHIV replication and mediate selection in vivo.Modulation of Gene Expression by Polymer Nanocapsule Delivery of DNA Cassettes Encoding Small RNAs.Generation of an HIV-1-resistant immune system with CD34(+) hematopoietic stem cells transduced with a triple-combination anti-HIV lentiviral vector.Sustained suppression of Bcr-Abl-driven lymphoid leukemia by microRNA mimics.Novel AgoshRNA molecules for silencing of the CCR5 co-receptor for HIV-1 infection.Ectopic expression of anti-HIV-1 shRNAs protects CD8(+) T cells modified with CD4ζ CAR from HIV-1 infection and alleviates impairment of cell proliferation.Multilineage polyclonal engraftment of Cal-1 gene-modified cells and in vivo selection after SHIV infection in a nonhuman primate model of AIDS Stable gene transfer of CCR5 and CXCR4 siRNAs by sleeping beauty transposon system to confer HIV-1 resistance.Monocyte/macrophages and their role in HIV neuropathogenesis.Genetic therapies against HIV.Genetically modified CD34+ hematopoietic stem cells contribute to turnover of brain perivascular macrophages in long-term repopulated primates.Specific transduction of HIV-susceptible cells for CCR5 knockdown and resistance to HIV infection: a novel method for targeted gene therapy and intracellular immunization.Eradication of HIV: current challenges and new directions.Applications of lentiviral vectors for shRNA delivery and transgenesis The feasibility of incorporating Vpx into lentiviral gene therapy vectors.Potent inhibition of HIV-1 by TRIM5-cyclophilin fusion proteins engineered from human components Towards a genetic AIDS vaccine.Phase 2 gene therapy trial of an anti-HIV ribozyme in autologous CD34+ cells.

P2860

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P2860

Stable reduction of CCR5 by RNAi through hematopoietic stem cell transplant in non-human primates.

http://www.wikidata.org/entity/Q35928777

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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2007年论文

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name

Stable reduction of CCR5 by RN ...... nsplant in non-human primates.

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Stable reduction of CCR5 by RN ...... nsplant in non-human primates.

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type

label

Stable reduction of CCR5 by RN ...... nsplant in non-human primates.

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Stable reduction of CCR5 by RN ...... nsplant in non-human primates.

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prefLabel

Stable reduction of CCR5 by RN ...... nsplant in non-human primates.

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Stable reduction of CCR5 by RN ...... nsplant in non-human primates.

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PNAS.0705474104

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Stable reduction of CCR5 by RN ...... nsplant in non-human primates.

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P2093

Allen E Krouse

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Aylin Bonifacino

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Betty Poon

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David Baltimore

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Dong Sung An

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F Xiao-Feng Qin

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Irvin S Y Chen

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Jean-Luc Darlix

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Mark Metzger

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Masakazu Kamata

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P2860

Real-time quantification of microRNAs by stem-loop RT-PCR

Short-term cytotoxic effects and long-term instability of RNAi delivered using lentiviral vectors

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease

Human immunodeficiency virus type 1 coreceptors participate in postentry stages in the virus replication cycle and function in simian immunodeficiency virus infection

Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene

Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection

A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection

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13110-13115

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10.1073/PNAS.0705474104

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104

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6168266

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17670939

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1941789

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