Growth inhibition and induction of differentiation of t(8;21) acute myeloid leukemia cells by the DNA-binding domain of PEBP2 and the AML1/MTG8(ETO)-specific antisense oligonucleotide.
about
A novel transcript encoding an N-terminally truncated AML1/PEBP2 alphaB protein interferes with transactivation and blocks granulocytic differentiation of 32Dcl3 myeloid cellsSubcellular localization of the alpha and beta subunits of the acute myeloid leukemia-linked transcription factor PEBP2/CBFIdentification of AML1-ETO modulators by chemical genomicsAML1 interconnected pathways of leukemogenesisExpression of the Runt domain-encoding PEBP2 alpha genes in T cells during thymic developmentRunt-related transcription factor 1 regulates luteinized hormone-induced prostaglandin-endoperoxide synthase 2 expression in rat periovulatory granulosa cellsRunx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartmentsIdentification of a new pebp2alphaA2 isoform from zebrafish runx2 capable of inducing osteocalcin gene expression in vitro.Transcriptional diversity during monocyte to macrophage differentiation.Runx1 directly promotes proliferation of hair follicle stem cells and epithelial tumor formation in mouse skin.Molecular and clinical advances in core binding factor primary acute myeloid leukemia: a paradigm for translational research in malignant hematology.AML1 and the AML1-ETO fusion protein in the pathogenesis of t(8;21) AML.Common themes in the pathogenesis of acute myeloid leukemia.Core-binding factor acute myeloid leukemia: Heterogeneity, monitoring, and therapy.Negative regulation of granulocytic differentiation in the myeloid precursor cell line 32Dcl3 by ear-2, a mammalian homolog of Drosophila seven-up, and a chimeric leukemogenic gene, AML1/ETO.The AML1/ETO fusion protein activates transcription of BCL-2Acute promyelocytic leukemia: a model of molecular target based therapy.AML1-ETO inhibits maturation of multiple lymphohematopoietic lineages and induces myeloblast transformation in synergy with ICSBP deficiencyp53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced deathThe extracellular signal-regulated kinase pathway phosphorylates AML1, an acute myeloid leukemia gene product, and potentially regulates its transactivation ability.Induction of apoptosis in myeloid leukaemic cells by ribozymes targeted against AML1/MTG8Differential gene expression profiles of gastric cancer cells established from primary tumour and malignant ascitesOverexpression of dopa decarboxylase in peritoneal dissemination of gastric cancer and its potential as a novel marker for the detection of peritoneal micrometastases with real-time RT-PCR.The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation.Induction of MTG8-specific cytotoxic T-cell lines: MTG8 is probably a tumour antigen that is recognized by cytotoxic T cells in AML1-MTG8-fused gene-positive acute myelogenous leukaemia.Cytoplasmic sequestration of the polyomavirus enhancer binding protein 2 (PEBP2)/core binding factor alpha (CBFalpha) subunit by the leukemia-related PEBP2/CBFbeta-SMMHC fusion protein inhibits PEBP2/CBF-mediated transactivation.Runt homology domain proteins in osteoblast differentiation: AML3/CBFA1 is a major component of a bone-specific complex.Williams-Beuren syndrome critical region-5/non-T-cell activation linker: a novel target gene of AML1/ETO.Identification of the chimeric protein product of the CBFB-MYH11 fusion gene in inv(16) leukemia cells.Tumour-amplified kinase BTAK is amplified and overexpressed in gastric cancers with possible involvement in aneuploid formation.Phorbol ester treatment of K562 cells regulates the transcriptional activity of AML1c through phosphorylation.Cleavage of AML1/MTG8 by asymmetric hammerhead ribozymes.Skeletal malformations caused by overexpression of Cbfa1 or its dominant negative form in chondrocytes.Proliferative activity of leukaemic blasts and cytosine arabinoside pharmacodynamics are associated with cytogenetically defined prognostic subgroups in acute myeloid leukaemia.Expression of AML1-ETO in human myelomonocytic cells selectively inhibits granulocytic differentiation and promotes their self-renewal.
P2860
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P2860
Growth inhibition and induction of differentiation of t(8;21) acute myeloid leukemia cells by the DNA-binding domain of PEBP2 and the AML1/MTG8(ETO)-specific antisense oligonucleotide.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Growth inhibition and inductio ...... fic antisense oligonucleotide.
@ast
Growth inhibition and inductio ...... fic antisense oligonucleotide.
@en
type
label
Growth inhibition and inductio ...... fic antisense oligonucleotide.
@ast
Growth inhibition and inductio ...... fic antisense oligonucleotide.
@en
prefLabel
Growth inhibition and inductio ...... fic antisense oligonucleotide.
@ast
Growth inhibition and inductio ...... fic antisense oligonucleotide.
@en
P2093
P2860
P356
P1476
Growth inhibition and inductio ...... fic antisense oligonucleotide.
@en
P2093
Hagiwara A
Murakami A
Sakakura C
Takahashi A
Takahashi T
Yamaguchi-Iwai Y
P2860
P304
11723-11727
P356
10.1073/PNAS.91.24.11723
P407
P577
1994-11-01T00:00:00Z