The AML1/ETO fusion protein activates transcription of BCL-2
about
Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemiasETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressorsAML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocationStructural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activityAssociation of MTG8 (ETO/CDR), a leukemia-related protein, with serine/threonine protein kinases and heat shock protein HSP90 in human hematopoietic cell linesAML1 interconnected pathways of leukemogenesisThe RUNX genes: gain or loss of function in cancerAML1/ETO oncoprotein is directed to AML1 binding regions and co-localizes with AML1 and HEB on its targets.Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis.The AML1-ETO chimaeric transcription factor in acute myeloid leukaemia: biology and clinical significance.AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: implication in stepwise leukemogenesis and response to Gleevec.Multiple functional domains of AML1: PU.1 and C/EBPalpha synergize with different regions of AML1Signalling pathways in the brain: cellular transduction of mood stabilisation in the treatment of manic-depressive illness.EB-1, a tyrosine kinase signal transduction gene, is transcriptionally activated in the t(1;19) subset of pre-B ALL, which express oncoprotein E2a-Pbx1.AML1-ETO fusion protein up-regulates TRKA mRNA expression in human CD34+ cells, allowing nerve growth factor-induced expansion.A novel ubiquitin-specific protease, UBP43, cloned from leukemia fusion protein AML1-ETO-expressing mice, functions in hematopoietic cell differentiation.Dichotomy of AML1-ETO functions: growth arrest versus block of differentiationThe leukemogenic t(8;21) fusion protein AML1-ETO controls rRNA genes and associates with nucleolar-organizing regions at mitotic chromosomes.AML1 and the AML1-ETO fusion protein in the pathogenesis of t(8;21) AML.Common themes in the pathogenesis of acute myeloid leukemia.Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?A histone acetyltransferase p300 inhibitor C646 induces cell cycle arrest and apoptosis selectively in AML1-ETO-positive AML cellsRUNX1 repression-independent mechanisms of leukemogenesis by fusion genes CBFB-MYH11 and AML1-ETO (RUNX1-RUNX1T1).Runx transcription factors repress human and murine c-Myc expression in a DNA-binding and C-terminally dependent manner.TEL-AML1 transgenic zebrafish model of precursor B cell acute lymphoblastic leukemia.Genome-wide co-occupancy of AML1-ETO and N-CoR defines the t(8;21) AML signature in leukemic cells.The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation.Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo.The Runx genes: lineage-specific oncogenes and tumor suppressors.The p21Waf1 pathway is involved in blocking leukemogenesis by the t(8;21) fusion protein AML1-ETO.Insertional mutagenesis identifies genes that promote the immortalization of primary bone marrow progenitor cellsNegative regulation of granulocytic differentiation in the myeloid precursor cell line 32Dcl3 by ear-2, a mammalian homolog of Drosophila seven-up, and a chimeric leukemogenic gene, AML1/ETO.Cell type dependent regulation of multidrug resistance-1 gene expression by AML1-ETO.Combined gene expression and DNA occupancy profiling identifies potential therapeutic targets of t(8;21) AML.Expression of the runt homology domain of RUNX1 disrupts homeostasis of hematopoietic stem cells and induces progression to myelodysplastic syndromep53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced deathInduction of apoptosis in myeloid leukaemic cells by ribozymes targeted against AML1/MTG8ETO, but not leukemogenic fusion protein AML1/ETO, augments RBP-Jkappa/SHARP-mediated repression of notch target genesThe t(8;21) chromosomal translocation in acute myelogenous leukemia modifies intranuclear targeting of the AML1/CBFalpha2 transcription factorFrom dissection of disease pathogenesis to elucidation of mechanisms of targeted therapies: leukemia research in the genomic era.
P2860
Q22009417-F07D79C6-9A61-43BD-9A36-D7D9F6A2A195Q24522848-98B6BDF1-80D7-4C9C-BC79-ED6E49C7BA28Q24681049-110B8327-3D7F-4FC5-8AC6-456DA9A98163Q27645524-E9294BAE-BE23-4C9F-AE8F-EAABCC8865D3Q28138744-D5461DC4-C19E-4C15-ABA3-FB244FA0B9A8Q28184349-12A32A2F-1838-4E44-AFA4-1FC0EF8E7CCCQ28247901-76A4BE38-9FD5-47A3-B89E-C107A9AB5F0AQ33388188-5CC4E624-AF81-465F-B172-193A8A8A6408Q33697376-EDBB15C9-8A88-472A-84D3-BC0726CC9C40Q33719096-4755E51E-543C-4E58-960D-B2DA8B704CC1Q33762738-47E2C003-EC33-40A4-9BC6-53EB5A8298B0Q33774804-FC02897C-CF3C-4EDE-A26D-85AD330B6750Q33809252-84AD86B2-0308-480F-A060-7235E4DE34ABQ33874482-F9284EA3-89C0-48AC-9E62-E2B6A29FB8C9Q33932435-132A8AAC-5932-49B7-802C-D6AB64E3F844Q33957786-736168D8-E2A8-404B-A3ED-B987D85FCFFDQ33969245-BF4D18CB-1A0A-416F-9128-8B993D02134CQ33995514-E5C0D446-FE10-4BBE-BD69-B0D4AAEEE878Q34405452-37DA73F2-A234-4084-BA37-293BFF5FDFEFQ34405458-8C32233B-C6C0-4E1A-B230-D4666B6C6BDAQ34542144-6B66E8B6-D77E-486A-868C-8E8A6FB82C2CQ34580082-AE14B878-D002-4074-ABD5-DAC1DD260F54Q34621037-9606DF3F-1264-4E31-8589-170CB0E4DC7DQ34852828-618A5936-E0DA-4E9C-83BD-8560E2A70CBBQ35108114-D19DF414-3912-42CF-965C-3D390547F53DQ35619449-41835D3D-F651-4B61-8139-94F5EE33DCEAQ35650662-C150B917-7C62-4D59-B9F4-AFA4F410439DQ35751083-2D9A4688-C743-4E68-B4D4-474F730975C9Q35779743-8FB77A08-76F4-4622-AE8D-BA8B628E7013Q35828623-92432B23-519F-4EEC-9556-CC28DF5BFB39Q35847760-7315CA1A-74A4-4710-8EF2-30D8DC7AC793Q35891618-31F3EA73-440A-49EB-BA8B-8F816D8A5B71Q36102812-96CC8B77-5083-4698-A26A-4B2CBAB3968AQ36177937-7002957C-D814-442F-90B9-4EDF91BD7EA4Q36395604-D02A0EF6-61D9-41ED-901B-EADDCD8C442BQ36445874-A91D1B7F-65E3-4399-8433-2E96BCF7D55DQ36619128-68724007-AEBB-4669-8B16-04588144308DQ36710850-572ED88C-BEFC-445D-A43B-E3D46263858EQ36775038-7A625EB2-1C17-40CF-AD98-8E824BAD66E8Q36920786-C6AA5268-E769-41F4-9DF1-2DD794168C11
P2860
The AML1/ETO fusion protein activates transcription of BCL-2
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
The AML1/ETO fusion protein activates transcription of BCL-2
@ast
The AML1/ETO fusion protein activates transcription of BCL-2
@en
type
label
The AML1/ETO fusion protein activates transcription of BCL-2
@ast
The AML1/ETO fusion protein activates transcription of BCL-2
@en
prefLabel
The AML1/ETO fusion protein activates transcription of BCL-2
@ast
The AML1/ETO fusion protein activates transcription of BCL-2
@en
P2093
P2860
P356
P1476
The AML1/ETO fusion protein activates transcription of BCL-2
@en
P2093
P2860
P304
14059-14064
P356
10.1073/PNAS.93.24.14059
P407
P577
1996-11-01T00:00:00Z