Inhibitors of protein geranylgeranyltransferase-I lead to prelamin A accumulation in cells by inhibiting ZMPSTE24

Inhibitors of protein geranylgeranyltransferase-I lead to prelamin A accumulation in cells by inhibiting ZMPSTE24

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http://www.wikidata.org/entity/Q35958478
Human isoprenoid synthase enzymes as therapeutic targetsIdentification of a farnesol analog as a Ras function inhibitor using both an in vivo Ras activation sensor and a phenotypic screening approach.AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrityGlucotoxic and diabetic conditions induce caspase 6-mediated degradation of nuclear lamin A in human islets, rodent islets and INS-1 832/13 cellsUse of synthetic isoprenoids to target protein prenylation and Rho GTPases in breast cancer invasionEfficient use of exogenous isoprenols for protein isoprenylation by MDA-MB-231 cells is regulated independently of the mevalonate pathwayGlucotoxic conditions induce endoplasmic reticulum stress to cause caspase 3 mediated lamin B degradation in pancreatic β-cells: protection by nifedipine.Progeroid syndrome patients with ZMPSTE24 deficiency could benefit when treated with rapamycin and dimethylsulfoxideTargeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria.Nifedipine prevents etoposide-induced caspase-3 activation, prenyl transferase degradation and loss in cell viability in pancreatic β-cells.LMNA missense mutations causing familial partial lipodystrophy do not lead to an accumulation of prelamin A.
P2860

Inhibitors of protein geranylgeranyltransferase-I lead to prelamin A accumulation in cells by inhibiting ZMPSTE24

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http://www.wikidata.org/entity/Q35958478
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2012 nî lūn-bûn
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Inhibitors of protein geranylg ...... n cells by inhibiting ZMPSTE24
@ast
Inhibitors of protein geranylg ...... n cells by inhibiting ZMPSTE24
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label
Inhibitors of protein geranylg ...... n cells by inhibiting ZMPSTE24
@ast
Inhibitors of protein geranylg ...... n cells by inhibiting ZMPSTE24
@en
prefLabel
Inhibitors of protein geranylg ...... n cells by inhibiting ZMPSTE24
@ast
Inhibitors of protein geranylg ...... n cells by inhibiting ZMPSTE24
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P698
P932
P356
P1433
P1476
Inhibitors of protein geranylg ...... n cells by inhibiting ZMPSTE24
@en
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P698
P932