Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic beta cells. - Wikidata - awgldk - TriplyDB

Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic beta cells.

Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic beta cells.

http://www.wikidata.org/entity/Q35970911

about

Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6 Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1 Natural history of β-cell adaptation and failure in type 2 diabetes Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size Adhesion-dependent Skp2 transcription requires selenocysteine tRNA gene transcription-activating factor (STAF)p27(Kip1) controls cytokinesis via the regulation of citron kinase activation.Cytoplasmic-nuclear trafficking of G1/S cell cycle molecules and adult human β-cell replication: a revised model of human β-cell G1/S control Deletion of the mitochondrial flavoprotein apoptosis inducing factor (AIF) induces beta-cell apoptosis and impairs beta-cell mass.Normal proliferation and tumorigenesis but impaired pancreatic function in mice lacking the cell cycle regulator sei1.Successful β cells islet regeneration in streptozotocin-induced diabetic baboons using ultrasound-targeted microbubble gene therapy with cyclinD2/CDK4/GLP1.The negative cell cycle regulators, p27(Kip1), p18(Ink4c), and GSK-3, play critical role in maintaining quiescence of adult human pancreatic β-cells and restrict their ability to proliferate.Repurposing cAMP-modulating medications to promote β-cell replication.Increasing β-cell mass requires additional stimulation for adaptation to secretory demand Age-dependent decline in beta-cell proliferation restricts the capacity of beta-cell regeneration in mice.Roles of F-box proteins in cancer Cyclin C stimulates β-cell proliferation in rat and human pancreatic β-cells The role of Skp2 in hematopoietic stem cell quiescence, pool size, and self-renewal Skp2 is required for incretin hormone-mediated β-cell proliferation Skp2-macroH2A1-CDK8 axis orchestrates G2/M transition and tumorigenesis.Transient overexpression of cyclin D2/CDK4/GLP1 genes induces proliferation and differentiation of adult pancreatic progenitors and mediates islet regeneration DNA methylation directs functional maturation of pancreatic β cells.Human β-cell proliferation and intracellular signaling: driving in the dark without a road map.Metabolic effects of intermittent hypoxia in mice: steady versus high-frequency applied hypoxia daily during the rest period.DNMT1 represses p53 to maintain progenitor cell survival during pancreatic organogenesis Prenatal Testosterone Exposure Leads to Gonadal Hormone-Dependent Hyperinsulinemia and Gonadal Hormone-Independent Glucose Intolerance in Adult Male Rat Offspring Expansion of beta-cell mass in response to pregnancy Dicer1 is required to repress neuronal fate during endocrine cell maturation.Inhibition of TGF-β Signaling Promotes Human Pancreatic β-Cell Replication.Exendin-4 stimulation of cyclin A2 in beta-cell proliferation.TGF-β Signaling Regulates Pancreatic β-Cell Proliferation through Control of Cell Cycle Regulator p27 Expression.Human pancreatic β-cell G1/S molecule cell cycle atlas.RIG-I inhibits pancreatic β cell proliferation through competitive binding of activated Src.Survey of the human pancreatic beta-cell G1/S proteome reveals a potential therapeutic role for cdk-6 and cyclin D1 in enhancing human beta-cell replication and function in vivo.Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation.Diminished pancreatic beta-cell mass in securin-null mice is caused by beta-cell apoptosis and senescence Minireview: Meeting the demand for insulin: molecular mechanisms of adaptive postnatal beta-cell mass expansion Combined modulation of polycomb and trithorax genes rejuvenates β cell replication Emerging roles for the ubiquitin-proteasome system and autophagy in pancreatic beta-cells.The transcriptional response of the islet to pregnancy in mice.High Fat Diet Regulation of β-Cell Proliferation and β-Cell Mass.

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P2860

Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic beta cells.

http://www.wikidata.org/entity/Q35970911

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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2007年论文

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name

Essential role of Skp2-mediate ...... sion of pancreatic beta cells.

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Essential role of Skp2-mediate ...... sion of pancreatic beta cells.

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type

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Essential role of Skp2-mediate ...... sion of pancreatic beta cells.

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Essential role of Skp2-mediate ...... sion of pancreatic beta cells.

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Essential role of Skp2-mediate ...... sion of pancreatic beta cells.

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Journal of Clinical Investigation

P1476

Essential role of Skp2-mediate ...... sion of pancreatic beta cells.

@en

P2093

Anil Bhushan

http://www.w3.org/2001/XMLSchema#string

Keiichi Nakayama

http://www.w3.org/2001/XMLSchema#string

Keiko Nakayama

http://www.w3.org/2001/XMLSchema#string

Lingwen Zhong

http://www.w3.org/2001/XMLSchema#string

Senta Georgia

http://www.w3.org/2001/XMLSchema#string

Shuen-Ing Tschen

http://www.w3.org/2001/XMLSchema#string

P2860

p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia

Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication

Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression

Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27

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2869-2876

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scholarly article

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10.1172/JCI32198

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10

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117

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6016095

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17823659

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1964513

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