Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation. - Wikidata - awgldk - TriplyDB

Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation.

Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation.

http://www.wikidata.org/entity/Q37175990

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Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6 The role of epigenetics in the pathology of diabetic complications RhoB loss prevents streptozotocin-induced diabetes and ameliorates diabetic complications in mice Epigenetics: a molecular link between environmental factors and type 2 diabetes Changes in Regenerative Capacity through Lifespan Epigenetic Regulation of Islet Development and Regeneration Epithelial-mesenchymal transition and cancer stemness: the Twist1-Bmi1 connection Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer Bmi-1 promotes glioma angiogenesis by activating NF-κB signaling Pcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in mice Long noncoding RNA variations in cardiometabolic diseases.Islet biology, the CDKN2A/B locus and type 2 diabetes risk.Activation of Wnt/β-catenin signaling by lithium chloride attenuates d-galactose-induced neurodegeneration in the auditory cortex of a rat model of aging.Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk.Postnatal development, maturation and aging in the mouse cochlea and their effects on hair cell regeneration.Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy.Islet microenvironment, modulated by vascular endothelial growth factor-A signaling, promotes β cell regeneration.Impact papers on aging in 2009.Chromatin modifications as determinants of muscle stem cell quiescence and chronological aging.Tissue-specific p19Arf regulation dictates the response to oncogenic K-ras.Superior efficacy of a combined epigenetic therapy against human mantle cell lymphoma cells.Gene expression profiles of Beta-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes.The molecular balancing act of p16(INK4a) in cancer and aging.Glucose and aging control the quiescence period that follows pancreatic beta cell replication Age-related impairment of pancreatic Beta-cell function: pathophysiological and cellular mechanisms.Identification and characterization of Bmi-1-responding element within the human p16 promoter.Co-delivery of doxorubicin and Bmi1 siRNA by folate receptor targeted liposomes exhibits enhanced anti-tumor effects in vitro and in vivo.Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock.Pancreatic beta-cells: from generation to regeneration.Bmi-1 promotes the aggressiveness of glioma via activating the NF-kappaB/MMP-9 signaling pathway.The Polycomb protein, Bmi1, regulates insulin sensitivity Bmi1 enhances tumorigenicity and cancer stem cell function in pancreatic adenocarcinoma.Validation of Bmi1 as a therapeutic target of hepatocellular carcinoma in mice.Epigenetic mechanisms in diabetic vascular complications.Heavy metals and epigenetic alterations in brain tumors.A systems view of epigenetic networks regulating pancreas development and β-cell function Deconstructing pancreas development to reconstruct human islets from pluripotent stem cells.The histone lysine demethylase JMJD3/KDM6B is recruited to p53 bound promoters and enhancer elements in a p53 dependent manner.Type 2 diabetes and the aging pancreatic beta cell.Transgenic overexpression of the transcription factor Nkx6.1 in β-cells of mice does not increase β-cell proliferation, β-cell mass, or improve glucose clearance.

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P2860

Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation.

http://www.wikidata.org/entity/Q37175990

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on April 2009

@en

vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation.

@en

Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation.

@nl

type

label

Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation.

@en

Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation.

@nl

prefLabel

Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation.

@en

Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation.

@nl

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Genes & Development

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Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation.

@en

P2093

Anil Bhushan

http://www.w3.org/2001/XMLSchema#string

Sangeeta Dhawan

http://www.w3.org/2001/XMLSchema#string

Shuen-Ing Tschen

http://www.w3.org/2001/XMLSchema#string

P2860

Role of histone H2A ubiquitination in Polycomb silencing

Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation

The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

p16INK4a induces an age-dependent decline in islet regenerative potential

Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing

Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene

Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice.

Ink4a/Arf expression is a biomarker of aging

Deubiquitylation of histone H2A activates transcriptional initiation via trans-histone cross-talk with H3K4 di- and trimethylation

Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation

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906-911

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scholarly article

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10.1101/GAD.1742609

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8

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23

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2009-04-01T00:00:00Z

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19390085

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2675870

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