Redesign of glycopeptide antibiotics: back to the future
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Targeting Antibiotic ResistanceEnzymatic glycosylation of vancomycin aglycon: completion of a total synthesis of vancomycin and N- and C-terminus substituent effects of the aglycon substrateNatural product synthesis at the interface of chemistry and biology.Total synthesis of [Ψ[C(═NH)NH]Tpg(4)]vancomycin and its (4-chlorobiphenyl)methyl derivative: impact of peripheral modifications on vancomycin analogues redesigned for dual D-Ala-D-Ala and D-Ala-D-Lac binding.The evolving role of chemical synthesis in antibacterial drug discovery.Axinellamines as broad-spectrum antibacterial agents: scalable synthesis and biology.Structure diversification of vancomycin through peptide-catalyzed, site-selective lipidation: a catalysis-based approach to combat glycopeptide-resistant pathogens.Total syntheses and initial evaluation of [Ψ[C(═S)NH]Tpg⁴]vancomycin, [Ψ[C(═NH)NH]Tpg⁴]vancomycin, [Ψ[CH₂NH]Tpg⁴]vancomycin, and their (4-chlorobiphenyl)methyl derivatives: synergistic binding pocket and peripheral modifications for the glycopeptideTotal synthesis of clostrubin.Silver(I)-promoted conversion of thioamides to amidines: divergent synthesis of a key series of vancomycin aglycon residue 4 amidines that clarify binding behavior to model ligandsA stepwise dechlorination/cross-coupling strategy to diversify the vancomycin 'in-chloride'.A Pd(0)-mediated indole (macro)cyclization reaction.Probing the role of the vancomycin e-ring aryl chloride: selective divergent synthesis and evaluation of alternatively substituted E-ring analogues.Investigation into the functional impact of the vancomycin C-ring aryl chlorideChemical tailoring of teicoplanin with site-selective reactionsProspects for new antibiotics: a molecule-centered perspective.Combating multidrug-resistant bacteria: current strategies for the discovery of novel antibacterials.Staphylococcus aureus Penicillin-Binding Protein 2 Can Use Depsi-Lipid II Derived from Vancomycin-Resistant Strains for Cell Wall Synthesis.vanO, a new glycopeptide resistance operon in environmental Rhodococcus equi isolates.Old and New Glycopeptide Antibiotics: Action and Resistance.Membrane Disruption and Enhanced Inhibition of Cell-Wall Biosynthesis: A Synergistic Approach to Tackle Vancomycin-Resistant Bacteria.Total Syntheses of Vancomycin-Related Glycopeptide Antibiotics and Key Analogues.Applications of Nonenzymatic Catalysts to the Alteration of Natural Products.Peripheral modifications of [Ψ[CH2NH]Tpg4]vancomycin with added synergistic mechanisms of action provide durable and potent antibiotics.A Vancomycin Derivative with a Pyrophosphate-Binding Group: A Strategy to Combat Vancomycin-Resistant Bacteria.Tackling vancomycin-resistant bacteria with 'lipophilic-vancomycin-carbohydrate conjugates'.Deciphering the mode of action of cell wall-inhibiting antibiotics using metabolic labeling of growing peptidoglycan in Streptococcus pyogenes.The Difference a Single Atom Can Make: Synthesis and Design at the Chemistry-Biology Interface.A biocompatible betaine-functionalized polycation for coacervation.Developments in Glycopeptide Antibiotics.Glycotriazole-peptides derived from the peptide HSP1: synergistic effect of triazole and saccharide rings on the antifungal activity.New insights into glycopeptide antibiotic binding to cell wall precursors using SPR and NMR spectroscopy.3-Hydroxy-1,5-dihydro-2H-pyrrol-2-ones as novel antibacterial scaffolds against methicillin-resistant Staphylococcus aureus.
P2860
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P2860
Redesign of glycopeptide antibiotics: back to the future
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Redesign of glycopeptide antibiotics: back to the future
@ast
Redesign of glycopeptide antibiotics: back to the future
@en
type
label
Redesign of glycopeptide antibiotics: back to the future
@ast
Redesign of glycopeptide antibiotics: back to the future
@en
prefLabel
Redesign of glycopeptide antibiotics: back to the future
@ast
Redesign of glycopeptide antibiotics: back to the future
@en
P2093
P2860
P356
P1433
P1476
Redesign of glycopeptide antibiotics: back to the future
@en
P2093
Akinori Okano
Dale L Boger
Joshua G Pierce
Robert C James
P2860
P304
P356
10.1021/CB300007J
P577
2012-02-21T00:00:00Z