NMR-based techniques in the hit identification and optimisation processes.
about
Leveraging structure determination with fragment screening for infectious disease drug targets: MECP synthase from Burkholderia pseudomalleiTargeting Zinc Finger Domains with Small Molecules: Solution Structure and Binding Studies of the RanBP2-Type Zinc Finger of RBM5Monitoring binding of HIV-1 capsid assembly inhibitors using (19)F ligand-and (15)N protein-based NMR and X-ray crystallography: early hit validation of a benzodiazepine seriesDiscovery of ligands for Nurr1 by combined use of NMR screening with different isotopic and spin-labeling strategies.NMR-based design and evaluation of novel bidentate inhibitors of the protein tyrosine phosphatase YopH.Rapid acquisition of 1H and 19F NMR experiments for direct and competition ligand-based screening.Efficient synthetic inhibitors of anthrax lethal factor.HTS by NMR of combinatorial libraries: a fragment-based approach to ligand discovery.Perspectives on NMR in drug discovery: a technique comes of ageStructure-activity relationships by interligand NOE-based design and synthesis of antiapoptotic compounds targeting Bid.Saturation transfer difference NMR for fragment screening.High-Throughput Screening (HTS) by NMR Guided Identification of Novel Agents Targeting the Protein Docking Domain of YopH.NMR-Assisted Molecular Docking Methodologies.Targeting tumor invasion: the roles of MDA-9/Syntenin.Targeting the PTPome in human disease.NMR-based approaches for the identification and optimization of inhibitors of protein-protein interactions.SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.Targeting historically refractory interfaces: a partnership model that accelerates drug discovery within an expanded haystack.Computer vision-based automated peak picking applied to protein NMR spectra.Development of molecular probes for second-site screening and design of protein tyrosine phosphatase inhibitorsThe biochemical effect of Ser166 phosphorylation on Euplotes octocarinatus centrin.In vitro visualization of betaine aldehyde synthesis and oxidation using hyperpolarized magnetic resonance spectroscopy.The Sam-Sam interaction between Ship2 and the EphA2 receptor: design and analysis of peptide inhibitors.Mapping functional interaction sites of human prune C-terminal domain by NMR spectroscopy in human cell lysates.Targeting EphA2-Sam and Its Interactome: Design and Evaluation of Helical Peptides Enriched in Charged Residues.
P2860
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P2860
NMR-based techniques in the hit identification and optimisation processes.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
NMR-based techniques in the hit identification and optimisation processes.
@ast
NMR-based techniques in the hit identification and optimisation processes.
@en
type
label
NMR-based techniques in the hit identification and optimisation processes.
@ast
NMR-based techniques in the hit identification and optimisation processes.
@en
prefLabel
NMR-based techniques in the hit identification and optimisation processes.
@ast
NMR-based techniques in the hit identification and optimisation processes.
@en
P2093
P2860
P50
P356
P1476
NMR-based techniques in the hit identification and optimisation processes.
@en
P2093
Dawoon Jung
Kevin J Crowell
Lutz Tautz
Maurizio Pellecchia
Tomas Mustelin
P2860
P304
P356
10.1517/14728222.8.6.597
P407
P577
2004-12-01T00:00:00Z