Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice
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Interactions of metals and Apolipoprotein E in Alzheimer's diseaseOxidative Stress Signaling in Alzheimers DiseaseApolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's diseaseAlzheimer mechanisms and therapeutic strategiesArf4 determines dentate gyrus-mediated pattern separation by regulating dendritic spine developmentImpact of apolipoprotein E on Alzheimer's diseaseRelationships between expression of apolipoprotein E and beta-amyloid precursor protein are altered in proximity to Alzheimer beta-amyloid plaques: potential explanations from cell culture studiesRosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neuronsReduced hippocampal activation during episodic encoding in middle-aged individuals at genetic risk of Alzheimer's disease: a cross-sectional studyAPOE genotype and stress response - a mini reviewThe Rationale for Insulin Therapy in Alzheimer's DiseaseApolipoprotein E: from cardiovascular disease to neurodegenerative disordersProteolytic cleavage of apolipoprotein E4 as the keystone for the heightened risk associated with Alzheimer's diseaseOxidized cholesterol as the driving force behind the development of Alzheimer's diseaseStructural basis for the recognition and cross-linking of amyloid fibrils by human apolipoprotein ENeuroprotective Sirtuin ratio reversed by ApoE4Apolipoprotein E: isoform specific differences in tertiary structure and interaction with amyloid-β in human Alzheimer brainProteomic analysis of mitochondria in APOE transgenic mice and in response to an ischemic challengeThe ε3 and ε4 alleles of human APOE differentially affect tau phosphorylation in hyperinsulinemic and pioglitazone treated miceSmall-molecule structure correctors target abnormal protein structure and function: structure corrector rescue of apolipoprotein E4-associated neuropathologyApolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice.GABAergic interneuron dysfunction impairs hippocampal neurogenesis in adult apolipoprotein E4 knockin mice.Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctorsMolecular basis for increased risk for late-onset Alzheimer disease due to the naturally occurring L28P mutation in apolipoprotein E4.The efficiency of protein compartmentalization into the secretory pathway.Cholesterol in the Pathogenesis of Alzheimer's, Parkinson's Diseases and Autism: Link to Synaptic DysfunctionNuclear uptake of an amino-terminal fragment of apolipoprotein E4 promotes cell death and localizes within microglia of the Alzheimer's disease brain.Sampling the N-terminal proteome of human blood.Genetically altering Abeta distribution from the brain to the vasculature ameliorates tau pathologyApolipoprotein E - A Multifunctional Protein with Implications in Various Pathologies as a Result of Its Structural FeaturesThe effect of apolipoprotein E (ApoE) genotype on biomarkers of amyloidogenesis, tau pathology and neurodegeneration in Alzheimer's disease.Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's diseaseAn apolipoprotein E4 fragment can promote intracellular accumulation of amyloid peptide beta 42APOE and neuroenergetics: an emerging paradigm in Alzheimer's disease.Genetic connections between neurological disorders and cholesterol metabolismSmall molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons.Structural variation in human apolipoprotein E3 and E4: secondary structure, tertiary structure, and size distribution.Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicityApolipoprotein E4 produced in GABAergic interneurons causes learning and memory deficits in miceAPOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF Aβ42
P2860
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P2860
Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Carboxyl-terminal-truncated ap ...... al deficits in transgenic mice
@ast
Carboxyl-terminal-truncated ap ...... al deficits in transgenic mice
@en
type
label
Carboxyl-terminal-truncated ap ...... al deficits in transgenic mice
@ast
Carboxyl-terminal-truncated ap ...... al deficits in transgenic mice
@en
prefLabel
Carboxyl-terminal-truncated ap ...... al deficits in transgenic mice
@ast
Carboxyl-terminal-truncated ap ...... al deficits in transgenic mice
@en
P2093
P2860
P356
P1476
Carboxyl-terminal-truncated ap ...... al deficits in transgenic mice
@en
P2093
Faith M Harris
Ina Tesseur
Jo Dee Fish
Karl H Weisgraber
Kimberly Scearce-Levie
Lennart Mucke
Lisa Kekonius
Paul C Hopkins
Robert W Mahley
P2860
P304
10966-10971
P356
10.1073/PNAS.1434398100
P407
P577
2003-08-25T00:00:00Z