Requirement for an initial signal from the membrane-proximal region of the interleukin 2 receptor gamma(c) chain for Janus kinase activation leading to T cell proliferation.

Requirement for an initial signal from the membrane-proximal region of the interleukin 2 receptor gamma(c) chain for Janus kinase activation leading to T cell proliferation.

Item
http://www.wikidata.org/entity/Q36026082
Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activationA new tyrosine-phosphorylated 97-kDa adaptor protein mediates interleukin-2-induced association of SHP-2 with p85-phosphatidylinositol 3-kinase in human T lymphocytes.Janus kinase 3 (Jak3) is essential for common cytokine receptor gamma chain (gamma(c))-dependent signaling: comparative analysis of gamma(c), Jak3, and gamma(c) and Jak3 double-deficient mice.Interleukin-2 receptor downstream events in regulatory T cells: implications for the choice of immunosuppressive drug therapyEnhanced signaling through the IL-2 receptor in CD8+ T cells regulated by antigen recognition results in preferential proliferation and expansion of responding CD8+ T cells rather than promotion of cell deathDifferential requirement of the cytoplasmic subregions of gamma c chain in T cell development and function.Identification of novel targets of immunosuppressive agents by cDNA-based microarray analysis.Critical role of the membrane-proximal, proline-rich motif of the interleukin-2 receptor gammac chain in the Jak3-independent signal transduction.The common γ-chain cytokine receptor: tricks-and-treats for T cells.Anti-apoptotic signaling by the interleukin-2 receptor reveals a function for cytoplasmic tyrosine residues within the common gamma (gamma c) receptor subunit.Studies with chimeric Mpl/JAK2 receptors indicate that both JAK2 and the membrane-proximal domain of Mpl are required for cellular proliferation.Differential substrate recognition capabilities of Janus family protein tyrosine kinases within the interleukin 2 receptor (IL2R) system: Jak3 as a potential molecular target for treatment of leukemias with a hyperactive Jak-Stat signaling machineryThe interleukin-4 receptor activates STAT5 by a mechanism that relies upon common gamma-chain.The cell surface expression level of the human interleukin-5 receptor alpha subunit determines the agonistic/antagonistic balance of the human interleukin-5 E13Q mutein.
P2860

Requirement for an initial signal from the membrane-proximal region of the interleukin 2 receptor gamma(c) chain for Janus kinase activation leading to T cell proliferation.

Item
http://www.wikidata.org/entity/Q36026082
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Requirement for an initial sig ...... ading to T cell proliferation.
@ast
Requirement for an initial sig ...... ading to T cell proliferation.
@en
type
label
Requirement for an initial sig ...... ading to T cell proliferation.
@ast
Requirement for an initial sig ...... ading to T cell proliferation.
@en
prefLabel
Requirement for an initial sig ...... ading to T cell proliferation.
@ast
Requirement for an initial sig ...... ading to T cell proliferation.
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P932
P356
P1433
P1476
Requirement for an initial sig ...... ading to T cell proliferation.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P932