Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway. - Wikidata - awgldk - TriplyDB

Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway.

Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway.

http://www.wikidata.org/entity/Q36117201

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Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy Lacritin rescues stressed epithelia via rapid forkhead box O3 (FOXO3)-associated autophagy that restores metabolism Aging as an event of proteostasis collapse Intracellular degradation of misfolded proteins in polyglutamine neurodegenerative diseases Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection The pathogenesis of Niemann-Pick type C disease: a role for autophagy?Cullin-RING ligases in regulation of autophagy Role of autophagy in chronic kidney diseases Autophagy, nutrition and immunology PAMPs and DAMPs: signal 0s that spur autophagy and immunity Reinstating aberrant mTORC1 activity in Huntington's disease mice improves disease phenotypes.RUN and FYVE domain-containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4.High-content chemical and RNAi screens for suppressors of neurotoxicity in a Huntington's disease model Maintenance of basal levels of autophagy in Huntington's disease mouse models displaying metabolic dysfunction Autophagosome dynamics in neurodegeneration at a glance Aggresome formation and neurodegenerative diseases: therapeutic implications Disruption of neuronal autophagy by infected microglia results in neurodegeneration Dysregulation of C/EBPalpha by mutant Huntingtin causes the urea cycle deficiency in Huntington's disease Regulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesis Proteotoxic stress induces phosphorylation of p62/SQSTM1 by ULK1 to regulate selective autophagic clearance of protein aggregates PARP-1 Inhibition Is Neuroprotective in the R6/2 Mouse Model of Huntington's Disease Identification of a candidate therapeutic autophagy-inducing peptide Autophagy gone awry in neurodegenerative diseases Proteomic analysis of wild-type and mutant huntingtin-associated proteins in mouse brains identifies unique interactions and involvement in protein synthesis.Deletion of the huntingtin polyglutamine stretch enhances neuronal autophagy and longevity in mice.ER-associated complexes (ERACs) containing aggregated cystic fibrosis transmembrane conductance regulator (CFTR) are degraded by autophagy.Diversity-Oriented Stapling Yields Intrinsically Cell-Penetrant Inducers of Autophagy.Proteasome activator enhances survival of Huntington's disease neuronal model cells PINK1 defect causes mitochondrial dysfunction, proteasomal deficit and alpha-synuclein aggregation in cell culture models of Parkinson's disease.Potent inhibitors of Huntingtin protein aggregation in a cell-based assay The regulation of N-terminal Huntingtin (Htt552) accumulation by Beclin1.Therapeutic Strategies in Huntington's Disease Lysosomal function in macromolecular homeostasis and bioenergetics in Parkinson's disease.Rapamycin and interleukin-1β impair brain-derived neurotrophic factor-dependent neuron survival by modulating autophagy.Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK and mTOR signaling pathways.An aggregation sensing reporter identifies leflunomide and teriflunomide as polyglutamine aggregate inhibitors.Reducing Igf-1r levels leads to paradoxical and sexually dimorphic effects in HD mice.Rhes suppression enhances disease phenotypes in Huntington's disease mice p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8⁺ T cells.

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Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway.

http://www.wikidata.org/entity/Q36117201

description

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Ai Yamamoto

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James E Rothman

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M Laura Cremona

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P2860

HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin

Role of IRS-2 in insulin and cytokine signalling

Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker

Tor-mediated induction of autophagy via an Apg1 protein kinase complex

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting.

Induction of autophagy and inhibition of tumorigenesis by beclin 1

Normal lysosomal morphology and function in LAMP-1-deficient mice

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