Molecular determinants of selectivity and efficacy at the dopamine D3 receptor.
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Dopamine D3 Receptor Antagonists as Potential Therapeutics for the Treatment of Neurological Diseases.A new mechanism of allostery in a G protein-coupled receptor dimerDopamine receptors - IUPHAR Review 13Beyond small-molecule SAR: using the dopamine D3 receptor crystal structure to guide drug designThe role of experimental and computational structural approaches in 7TM drug discovery.Beyond Membrane Protein Structure: Drug Discovery, Dynamics and Difficulties.Applying a multitarget rational drug design strategy: the first set of modulators with potent and balanced activity toward dopamine D3 receptor and fatty acid amide hydrolase.Discovery and characterization of a G protein-biased agonist that inhibits β-arrestin recruitment to the D2 dopamine receptorChiral Resolution and Serendipitous Fluorination Reaction for the Selective Dopamine D3 Receptor Antagonist BAK2-66Design, synthesis, and structure-activity relationship studies of a series of [4-(4-carboxamidobutyl)]-1-arylpiperazines: insights into structural features contributing to dopamine D3 versus D2 receptor subtype selectivity.Tranylcypromine substituted cis-hydroxycyclobutylnaphthamides as potent and selective dopamine D₃ receptor antagonists.Targeting the dopamine D3 receptor: an overview of drug design strategies.Mutation of three residues in the third intracellular loop of the dopamine D2 receptor creates an internalization-defective receptorPramipexole derivatives as potent and selective dopamine D(3) receptor agonists with improved human microsomal stability.What can crystal structures of aminergic receptors tell us about designing subtype-selective ligands?Structure-based ligand discovery targeting orthosteric and allosteric pockets of dopamine receptors.Multiple fragment docking and linking in primary and secondary pockets of dopamine receptors.Using click chemistry toward novel 1,2,3-triazole-linked dopamine D3 receptor ligands.Investigation of the binding and functional properties of extended length D3 dopamine receptor-selective antagonistsIdentifying Medication Targets for Psychostimulant Addiction: Unraveling the Dopamine D3 Receptor Hypothesis.Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity.High Affinity Dopamine D3 Receptor (D3R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D3R Knockout Mice.A single glycine in extracellular loop 1 is the critical determinant for pharmacological specificity of dopamine D2 and D3 receptors.Structural modifications of neuroprotective anti-Parkinsonian (-)-N6-(2-(4-(biphenyl-4-yl)piperazin-1-yl)-ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine (D-264): an effort toward the improvement of in vivo efficacy of the parent molDopamine D3 receptor antagonists: a patent review (2007 - 2012).X-ray structural information of GPCRs in drug design: what are the limitations and where do we go?Structure-based and fragment-based GPCR drug discovery.Insights into the structural biology of G-protein coupled receptors impacts drug design for central nervous system neurodegenerative processes.Intrinsic and Antipsychotic Drug-Induced Metabolic Dysfunction in Schizophrenia.Novel, Selective, and Developable Dopamine D3 Antagonists with a Modified "Amino" Region.Highly Selective Dopamine D3 Receptor (D3R) Antagonists and Partial Agonists Based on Eticlopride and the D3R Crystal Structure: New Leads for Opioid Dependence Treatment.Characterization of [(3) H]LS-3-134, a novel arylamide phenylpiperazine D3 dopamine receptor selective radioligand.Synthesis and in vitro pharmacological evaluation of indolyl carboxylic amide analogues as D3 dopamine receptor selective ligands.Design, synthesis, and evaluation of indolebutylamines as a novel class of selective dopamine D3 receptor ligands.Optical Control of Dopamine Receptors Using a Photoswitchable Tethered Inverse Agonist.D4 dopamine receptor high-resolution structures enable the discovery of selective agonists.Highly Selective Dopamine D3 Receptor Antagonists with Arylated Diazaspiro Alkane Cores.The action of a negative allosteric modulator at the dopamine D2 receptor is dependent upon sodium ions.Toward Understanding the Structural Basis of Partial Agonism at the Dopamine D3 Receptor.Challenges in the development of dopamine D2- and D3-selective radiotracers for PET imaging studies.
P2860
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P2860
Molecular determinants of selectivity and efficacy at the dopamine D3 receptor.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Molecular determinants of selectivity and efficacy at the dopamine D3 receptor.
@ast
Molecular determinants of selectivity and efficacy at the dopamine D3 receptor.
@en
type
label
Molecular determinants of selectivity and efficacy at the dopamine D3 receptor.
@ast
Molecular determinants of selectivity and efficacy at the dopamine D3 receptor.
@en
prefLabel
Molecular determinants of selectivity and efficacy at the dopamine D3 receptor.
@ast
Molecular determinants of selectivity and efficacy at the dopamine D3 receptor.
@en
P2093
P2860
P356
P1476
Molecular determinants of selectivity and efficacy at the dopamine D3 receptor
@en
P2093
Alex LaBounty
Amy Hauck Newman
Ashwini K Banala
Benjamin Levy
Jianjing Cao
Katherine Pongetti
Mayako Michino
Prashant Donthamsetti
Robert R Luedtke
Thijs Beuming
P2860
P304
P356
10.1021/JM300482H
P407
P577
2012-06-07T00:00:00Z