Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis

Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis

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http://www.wikidata.org/entity/Q36157057

Q36157057

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Ceramide synthases at the centre of sphingolipid metabolism and biology Mammalian ceramide synthases Roles of bioactive sphingolipids in cancer biology and therapeutics Autophagy paradox and ceramide Absence of perilipin 2 prevents hepatic steatosis, glucose intolerance and ceramide accumulation in alcohol-fed mice Ceramide induced mitophagy and tumor suppression A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis.Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways.The expression of sphingosine kinase-1 in head and neck carcinoma The impact of sphingosine kinase-1 in head and neck cancer.Re-configuration of sphingolipid metabolism by oncogenic transformation.Delineating metabolic signatures of head and neck squamous cell carcinoma: phospholipase A2, a potential therapeutic target.Gaucher's disease and cancer: a sphingolipid perspective Apoptotic sphingolipid ceramide in cancer therapy.Tetanus Toxin Hc Fragment Induces the Formation of Ceramide Platforms and Protects Neuronal Cells against Oxidative Stress.Individual profiles of free ceramide species and the constituent ceramide species of sphingomyelin and neutral glycosphingolipid and their alteration according to the sequential changes of environmental oxygen content in human colorectal cancer Caco Lipid Signaling in Tumorigenesis.Results of a phase II trial of gemcitabine plus doxorubicin in patients with recurrent head and neck cancers: serum C₁₈-ceramide as a novel biomarker for monitoring response.Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics.Magic angle spinning NMR-based metabolic profiling of head and neck squamous cell carcinoma tissues Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2+ and ER/Golgi membrane network.Serum Sphingolipid Variations Associate with Hepatic Decompensation and Survival in Patients with Cirrhosis.A role of sphingosine kinase 1 in head and neck carcinogenesis C6 pyridinium ceramide influences alternative pre-mRNA splicing by inhibiting protein phosphatase-1.Concerted functions of HDAC1 and microRNA-574-5p repress alternatively spliced ceramide synthase 1 expression in human cancer cells.Myriocin treatment of CF lung infection and inflammation: complex analyses for enigmatic lipids.Targeting ceramide synthase 6-dependent metastasis-prone phenotype in lung cancer cells.Ceramide limits phosphatidylinositol-3-kinase C2β-controlled cell motility in ovarian cancer: potential of ceramide as a metastasis-suppressor lipid Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy Screening for PPAR Responsive Regulatory Modules in Cancer.Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.Acid ceramidase upregulation in prostate cancer: role in tumor development and implications for therapy C2-ceramide induces cell death and protective autophagy in head and neck squamous cell carcinoma cells.Targeting sphingolipid metabolism in head and neck cancer: rational therapeutic potentials.Therapeutic applications of bioactive sphingolipids in hematological malignancies.Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance.Oncogene and non-oncogene addiction in inflammation-associated cancers.Transcriptional regulation of the human neutral ceramidase gene.Ceramide synthases in mammalians, worms, and insects: emerging schemes.Design of immunoprobes for electrochemical multiplexed tumor marker detection.

P2860

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P2860

Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis

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2007 nî lūn-bûn

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Clinical relevance of ceramide ...... invasion and nodal metastasis

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Can E Senkal

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Debajyoti Sinha

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Jacek Bielawski

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James S Norris

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Kesha Thomas

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M Boyd Gillespie

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Saeed Elojeimy

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Serap Koybasi

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Serdar Karahatay

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P2860

Upstream of growth and differentiation factor 1 (uog1), a mammalian homolog of the yeast longevity assurance gene 1 (LAG1), regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cells

Molecular predictors of clinical outcome in patients with head and neck squamous cell carcinoma.

Ceramide-1-phosphate promotes cell survival through activation of the phosphatidylinositol 3-kinase/protein kinase B pathway

Temporal relationships between ceramide production, caspase activation and mitochondrial dysfunction in cell lines with varying sensitivity to anti-Fas-induced apoptosis

Cancer statistics, 2005

Gender influences subsite of origin of laryngeal carcinoma.

Preliminary report on hormone receptors in the human vocal fold.

Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas.

When do Lasses (longevity assurance genes) become CerS (ceramide synthases)?: Insights into the regulation of ceramide synthesis.

Exogenous and intracellularly generated sphingosine 1-phosphate can regulate cellular processes by divergent pathways.

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Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis

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P2860

P2860

Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis

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