Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death.
about
Exquisite sensitivity of TP53 mutant and basal breast cancers to a dose-dense epirubicin-cyclophosphamide regimenSynergistic antitumor activity of oncolytic reovirus and chemotherapeutic agents in non-small cell lung cancer cellsUnstable microtubule capture at kinetochores depleted of the centromere-associated protein CENP-F.Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development.Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function.Inhibition of TRIP1/S8/hSug1, a component of the human 19S proteasome, enhances mitotic apoptosis induced by spindle poisonsCAMP (C13orf8, ZNF828) is a novel regulator of kinetochore-microtubule attachment.Cyclin-dependent kinase 1-mediated Bcl-xL/Bcl-2 phosphorylation acts as a functional link coupling mitotic arrest and apoptosisThe human synMuv-like protein LIN-9 is required for transcription of G2/M genes and for entry into mitosisMicrotubules do not promote mitotic slippage when the spindle assembly checkpoint cannot be satisfied.Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint.Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fateShugoshin-2 is essential for the completion of meiosis but not for mitotic cell division in miceDido disruption leads to centrosome amplification and mitotic checkpoint defects compromising chromosome stabilityHURP controls spindle dynamics to promote proper interkinetochore tension and efficient kinetochore capture.Cellular Pathways in Response to Ionizing Radiation and Their Targetability for Tumor RadiosensitizationTargeting the Mitotic Catastrophe Signaling Pathway in CancerMitotic Spindle Disruption by Alternating Electric Fields Leads to Improper Chromosome Segregation and Mitotic Catastrophe in Cancer Cells.The 3' untranslated region of the cyclin B mRNA is not sufficient to enhance the synthesis of cyclin B during a mitotic block in human cellsRAN nucleo-cytoplasmic transport and mitotic spindle assembly partners XPO7 and TPX2 are new prognostic biomarkers in serous epithelial ovarian cancerStem cells, senescence, neosis and self-renewal in cancer.Structural and mechanistic insights into Mps1 kinase activationUbiquitin and SUMO systems in the regulation of mitotic checkpointsIn-silico modeling of the mitotic spindle assembly checkpointSmall compound 6-O-angeloylplenolin induces mitotic arrest and exhibits therapeutic potentials in multiple myelomaMicroRNA-135b Regulates Leucine Zipper Tumor Suppressor 1 in Cutaneous Squamous Cell CarcinomaG2/M Cell Cycle Arrest and Tumor Selective Apoptosis of Acute Leukemia Cells by a Promising Benzophenone Thiosemicarbazone CompoundMitotic Checkpoint Kinase Mps1 Has a Role in Normal Physiology which Impacts Clinical UtilityKinetic cell-based morphological screening: prediction of mechanism of compound action and off-target effectsPrinciples of cancer therapy: oncogene and non-oncogene addictionInforming materials: drugs as tools for exploring cancer mechanisms and pathways.Spindle poisons and cell fate: a tale of two pathways.MLN8054, a small-molecule inhibitor of Aurora A, causes spindle pole and chromosome congression defects leading to aneuploidy.Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice.TAp73 regulates the spindle assembly checkpoint by modulating BubR1 activityAn automated fluorescence videomicroscopy assay for the detection of mitotic catastropheIC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation.Chromosomal instability in mouse embryonic fibroblasts null for the transcriptional co-repressor Ski.Rapid induction of apoptosis during Kinesin-5 inhibitor-induced mitotic arrest in HL60 cells.DNA damage causes TP53-dependent coupling of self-renewal and senescence pathways in embryonal carcinoma cells
P2860
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P2860
Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Decoding the links between mit ...... t, adaptation, and cell death.
@ast
Decoding the links between mit ...... t, adaptation, and cell death.
@en
type
label
Decoding the links between mit ...... t, adaptation, and cell death.
@ast
Decoding the links between mit ...... t, adaptation, and cell death.
@en
prefLabel
Decoding the links between mit ...... t, adaptation, and cell death.
@ast
Decoding the links between mit ...... t, adaptation, and cell death.
@en
P1433
P1476
Decoding the links between mit ...... nt, adaptation, and cell death
@en
P2093
Beth A A Weaver
P356
10.1016/J.CCR.2005.06.011
P577
2005-07-01T00:00:00Z