Structure-functional selectivity relationship studies of β-arrestin-biased dopamine D₂ receptor agonists. - Wikidata - awgldk - TriplyDB

Structure-functional selectivity relationship studies of β-arrestin-biased dopamine D₂ receptor agonists.

Structure-functional selectivity relationship studies of β-arrestin-biased dopamine D₂ receptor agonists.

http://www.wikidata.org/entity/Q36237653

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The Treatment of Adult Bipolar Disorder with Aripiprazole: A Systematic Review Drug Repurposing Is a New Opportunity for Developing Drugs against Neuropsychiatric Disorders DREADDs: novel tools for drug discovery and development (-)-Stepholidine is a potent pan-dopamine receptor antagonist of both G protein- and β-arrestin-mediated signaling Dopamine receptors - IUPHAR Review 13 β-Arrestin-Dependent Dopaminergic Regulation of Calcium Channel Activity in the Axon Initial Segment.Discovery and characterization of a G protein-biased agonist that inhibits β-arrestin recruitment to the D2 dopamine receptor Selected rapporteur summaries from the XX World Congress of Psychiatric Genetics, Hamburg, Germany, October 14-18, 2012.Design, synthesis, and structure-activity relationship studies of a series of [4-(4-carboxamidobutyl)]-1-arylpiperazines: insights into structural features contributing to dopamine D3 versus D2 receptor subtype selectivity.Identification of novel functionally selective κ-opioid receptor scaffolds.Identification of G protein-biased agonists that fail to recruit β-arrestin or promote internalization of the D1 dopamine receptor.Functional Characterization of a Novel Series of Biased Signaling Dopamine D3 Receptor Agonists.Conformation guides molecular efficacy in docking screens of activated β-2 adrenergic G protein coupled receptor New functional activity of aripiprazole revealed: Robust antagonism of D2 dopamine receptor-stimulated Gβγ signaling Advances in receptor conformation research: the quest for functionally selective conformations focusing on the β2-adrenoceptor A pharmacological organization of G protein-coupled receptors.Structure-Activity Analysis of Biased Agonism at the Human Adenosine A3 Receptor.A single glycine in extracellular loop 1 is the critical determinant for pharmacological specificity of dopamine D2 and D3 receptors.Distinct cortical and striatal actions of a β-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties.Biased G Protein-Coupled Receptor Signaling: New Player in Modulating Physiology and Pathology Biased agonism at G protein-coupled receptors: the promise and the challenges--a medicinal chemistry perspective.Selectivity of pharmacological tools: implications for use in cell physiology. A review in the theme: Cell signaling: proteins, pathways and mechanisms.Biased agonism: An emerging paradigm in GPCR drug discovery.Advances and challenges in the search for D2 and D3 dopamine receptor-selective compounds.Insertion of arynes into N-halo bonds: a direct approach to o-haloaminoarenes.Multivalent approaches and beyond: novel tools for the investigation of dopamine D2 receptor pharmacology.Discovery of G Protein-Biased EP2 Receptor Agonists.Synthesis and cytotoxic activity evaluation of novel arylpiperazine derivatives on human prostate cancer cell lines.New Concepts in Dopamine D2 Receptor Biased Signaling and Implications for Schizophrenia Therapy.Colloidal aggregation causes inhibition of G protein-coupled receptors.Agonist signalling properties of radiotracers used for imaging of dopamine D2/3 receptors.Structure-bias relationships for fenoterol stereoisomers in six molecular and cellular assays at the β2-adrenoceptor.Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs.Discovery of new GPCR ligands to illuminate new biology.Discovery of G Protein-Biased D2 Dopamine Receptor Partial Agonists.Biased signalling: from simple switches to allosteric microprocessors.Pharmacological Chaperones as Potential Therapeutic Strategies for Misfolded Mutant Vasopressin Receptors.Drug discovery: Structure-led design.Structure-Activity Investigation of a G Protein-Biased Agonist Reveals Molecular Determinants for Biased Signaling of the D2 Dopamine Receptor.Evaluation of e-liquid toxicity using an open-source high-throughput screening assay.

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P2860

Structure-functional selectivity relationship studies of β-arrestin-biased dopamine D₂ receptor agonists.

http://www.wikidata.org/entity/Q36237653

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Structure-functional selectivi ...... dopamine D₂ receptor agonists.

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Structure-functional selectivi ...... dopamine D₂ receptor agonists.

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Structure-functional selectivi ...... dopamine D₂ receptor agonists.

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Journal of Medicinal Chemistry

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Structure-functional selectivi ...... dopamine D₂ receptor agonists.

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Bryan L Roth

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Jian Jin

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Lianyou Zheng

http://www.w3.org/2001/XMLSchema#string

Maria F Sassano

http://www.w3.org/2001/XMLSchema#string

Meng Chen

http://www.w3.org/2001/XMLSchema#string

Stephen V Frye

http://www.w3.org/2001/XMLSchema#string

Vincent Setola

http://www.w3.org/2001/XMLSchema#string

William C Wetsel

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Xin Chen

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Xu Bai

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P2860

Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes

Functional Selectivity and Classical Concepts of Quantitative Pharmacology

An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior

Arresting serotonin

The genetic design of signaling cascades to record receptor activation

NMR Chemical Shifts of Common Laboratory Solvents as Trace Impurities

Functional selectivity of dopamine receptor agonists. I. Selective activation of postsynaptic dopamine D2 receptors linked to adenylate cyclase

Functional selectivity of dopamine receptor agonists. II. Actions of dihydrexidine in D2L receptor-transfected MN9D cells and pituitary lactotrophs

Transduction of receptor signals by beta-arrestins

Interactions of the novel antipsychotic aripiprazole (OPC-14597) with dopamine and serotonin receptor subtypes

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16

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