Autistic-like behaviour in Scn1a+/- mice and rescue by enhanced GABA-mediated neurotransmission. - Wikidata - awgldk - TriplyDB

Autistic-like behaviour in Scn1a+/- mice and rescue by enhanced GABA-mediated neurotransmission.

Autistic-like behaviour in Scn1a+/- mice and rescue by enhanced GABA-mediated neurotransmission.

http://www.wikidata.org/entity/Q36252621

about

Neuropathology and animal models of autism: genetic and environmental factors New Therapeutic Options for Autism Spectrum Disorder: Experimental Evidences Behavioral phenotypes of genetic mouse models of autism.Excitatory/Inhibitory Balance and Circuit Homeostasis in Autism Spectrum Disorders Genetic epilepsy syndromes without structural brain abnormalities: clinical features and experimental models Channelopathy pathogenesis in autism spectrum disorders GABAergic signaling as therapeutic target for autism spectrum disorders Therapeutic approaches for shankopathies Axon initial segments: diverse and dynamic neuronal compartments Dissecting the phenotypes of Dravet syndrome by gene deletion Gamma rhythms link prefrontal interneuron dysfunction with cognitive inflexibility in Dlx5/6(+/-) mice.Pathogenesis and new candidate treatments for infantile spasms and early life epileptic encephalopathies: A view from preclinical studies Seizure-dependent mTOR activation in 5-HT neurons promotes autism-like behaviors in mice Genetic background modulates impaired excitability of inhibitory neurons in a mouse model of Dravet syndrome Early hyperactivity and precocious maturation of corticostriatal circuits in Shank3B(-/-) mice Cognitive deficits caused by a disease-mutation in the α3 Na(+)/K(+)-ATPase isoform.The parvalbumin/somatostatin ratio is increased in Pten mutant mice and by human PTEN ASD alleles.Elucidating an Affective Pain Circuit that Creates a Threat Memory PX-RICS-deficient mice mimic autism spectrum disorder in Jacobsen syndrome through impaired GABAA receptor trafficking Mutation of the CH1 Domain in the Histone Acetyltransferase CREBBP Results in Autism-Relevant Behaviors in Mice Opposite monosynaptic scaling of BLP-vCA1 inputs governs hopefulness- and helplessness-modulated spatial learning and memory Genetic aspects of autism spectrum disorders: insights from animal models Advancing the understanding of autism disease mechanisms through genetics Neuronal mechanisms and circuits underlying repetitive behaviors in mouse models of autism spectrum disorder Sodium channel β subunits: emerging targets in channelopathies Nav1.1 modulation by a novel triazole compound attenuates epileptic seizures in rodents Major channels involved in neuropsychiatric disorders and therapeutic perspectives GABAB Receptor Agonist R-Baclofen Reverses Social Deficits and Reduces Repetitive Behavior in Two Mouse Models of Autism Behavioral characteristics of ubiquitin-specific peptidase 46-deficient mice Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain Activity-dependent adaptations in inhibitory axons FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders Maternal and Early-Life Circadian Disruption Have Long-Lasting Negative Consequences on Offspring Development and Adult Behavior in Mice.MECP2 regulates cortical plasticity underlying a learned behaviour in adult female mice Prioritizing the development of mouse models for childhood brain disorders Sensory integration in mouse insular cortex reflects GABA circuit maturation GABAA receptor subtypes: Therapeutic potential in Down syndrome, affective disorders, schizophrenia, and autism.Diversity of neuronal inhibition: a path to novel treatments for neuropsychiatric disorders.Towards identification of individual etiologies by resolving genomic and biological conundrums in patients with autism spectrum disorders.GABA progenitors grafted into the adult epileptic brain control seizures and abnormal behavior

P2860

Q21284779-7148107F-9D91-4AB0-9FF0-00388B352650 Q26771762-38244586-D71B-47F4-8C33-54ECE3BB206F Q26781456-96AFA71E-544A-448A-B0B3-72AB4CFDE886 Q26796321-08045BC1-5687-4A69-8396-99A2F7697DB2 Q26861471-CDFDCE73-ADDE-442B-8403-190FDDB70633 Q26864726-AEF8659D-F112-492A-AAA2-0E7FF71F04C1 Q27013583-9935B599-E1FB-4642-906E-2ECE0FFF9B7A Q27024976-FE73281B-877F-410D-B205-C75901927AEB Q27025814-75B30182-2ADF-42F7-8ED4-DFABCAD38C54 Q27303721-24C4B580-299A-47D7-875C-7D70C628C7D4 Q27305944-4D8471DE-1EA8-4A8D-BE69-33A86B7A3963 Q27308052-E842F424-05C0-4329-B3CB-A6757E2DB14E Q27308143-4FA5198B-1554-4C73-88BA-346F62D4374F Q27308208-6F4A0919-21D3-4CC5-9D07-337079F23079 Q27311527-7E11B7CA-7F36-43BB-BFB4-7008F5E4D87E Q27315555-F7C3D13A-D0BA-445C-A946-91DECE1C051B Q27320524-BE341AAE-CB65-4DA6-9138-86FD4F982CEC Q27322610-9851CAAE-E077-4E5E-8C62-E1ED4E044E33 Q27326861-76AA6983-5B2F-4333-83B7-F29D717E67F6 Q27332438-088C1CEB-73E8-46F6-9F8D-978904AF4B6F Q27342812-98C9DDF4-D129-4862-9FCE-0BE3DB81F326 Q27687011-C0A1FED1-2475-4CD8-A2F7-020039FCD4EF Q28069757-0692FCC8-3F8C-418F-A2F4-87CD243CB259 Q28071696-DCF07F01-8D22-461F-9F77-AE7AE20C6F88 Q28082122-B255B342-5383-403A-8538-C72EAF7AE8CF Q28235994-AB767773-0A98-416E-B75F-60EE1024C948 Q28290639-7ECFB6A0-70C0-4519-9935-0120C63F62DD Q28391720-A3CC3CA2-4FFC-4799-ADDE-13312133F323 Q28507136-214C258E-FAE7-496A-AAA0-2C217BE4E9FF Q28594552-FD321914-5E29-4C8A-AB6A-FD4DC7EB9FD4 Q28661510-9A62C672-99D3-4EA8-BEF7-626DF9E22FB5 Q28973611-02E1C07F-7EE6-4915-9776-4D6C3B103E4D Q30354349-DBE16892-4D8D-4FAC-8701-0C6EF95287BF Q30364233-72C20BD1-ACAE-4A0D-BB8E-6BA246C9BC69 Q30366940-AD4EAC74-6029-4104-B354-919938151CE0 Q30404712-ADA2E673-2622-44AF-932B-895E516E53ED Q30421260-1E83E1A6-A7DA-45D9-9E76-35FB25E41DBF Q30421954-7C00583E-1EDF-4EA6-ADA7-00F1A2DAA6CE Q30451842-94D45396-DA5C-4895-950B-9FA1F34E65F9 Q30540112-681AB648-E4B0-422E-A764-7BCF357AA300

P2860

Autistic-like behaviour in Scn1a+/- mice and rescue by enhanced GABA-mediated neurotransmission.

http://www.wikidata.org/entity/Q36252621

description

2012 nî lūn-bûn

@nan

2012年の論文

@ja

2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

2012年论文

@zh

2012年论文

@zh-cn

name

Autistic-like behaviour in Scn ...... BA-mediated neurotransmission.

@ast

Autistic-like behaviour in Scn ...... BA-mediated neurotransmission.

@en

type

label

Autistic-like behaviour in Scn ...... BA-mediated neurotransmission.

@ast

Autistic-like behaviour in Scn ...... BA-mediated neurotransmission.

@en

prefLabel

Autistic-like behaviour in Scn ...... BA-mediated neurotransmission.

@ast

Autistic-like behaviour in Scn ...... BA-mediated neurotransmission.

@en

P1433

Q36252621-001AA526-BA3F-41B7-AE73-9FEE5852EF49

P1476

Q36252621-DC35570F-27B9-47EB-9F6B-DC6FD6029D8B

P2093

Q36252621-6A7A6EDB-4CA7-4EA3-8D96-EE18467EEA0D

Q36252621-6CC146E2-1D00-4CE2-9BC8-239633216EB5

Q36252621-704BA9A0-DDE9-4EFE-9591-6F4E39A1ADF9

Q36252621-C420B13B-D265-49DB-A8A4-62259DE8FF84

Q36252621-C47BD58D-1A63-4890-8F09-FD5777764133

Q36252621-E94B39D7-856A-4141-BDC0-49F01A000E25

Q36252621-ED12A07A-66AC-4B73-BCDF-A5D3499562F3

Q36252621-F1E13C95-7D2E-4346-9BBF-92EDC6D4E1CB

P2860

Q36252621-03743229-C868-4574-9F9B-9C772295BE94

Q36252621-0AF7CD7E-5C5D-4B6C-89BB-9589E108CE52

Q36252621-1B0A77C8-C1AD-445F-89D5-097AB7568D14

Q36252621-20B48868-0AFD-462C-9F89-6B78EBB8525C

Q36252621-28666652-6186-4D18-BA8C-3492EC52F35A

Q36252621-3968037E-B1AB-42AF-9BE7-64408411CEBD

Q36252621-3F425A70-5A70-4213-AC15-E06AAAC7E33A

Q36252621-40003A97-9FBB-410D-AF63-F82DCA9EDAB1

Q36252621-4399E4B2-1BEA-407A-91DB-C8ECE0194AED

Q36252621-467F0EAE-A234-46B7-9C8F-70C5111D68CF

P2888

Q36252621-FD222FF3-482B-47E4-A0AC-1C1A3A5DAFF1

P304

Q36252621-8D13A205-1382-4FB1-A569-FEFC0A606B8F

P31

Q36252621-1BF0F721-D91D-4E22-8416-B8EE49405B02

P356

Q36252621-9370F4CB-6389-4B78-9D8B-A15D342236B7

P407

Q36252621-A61CB470-3EAC-4B5C-9257-1F633532EC07

P433

Q36252621-6AEC0F2A-A5CA-4D39-B1F0-AB4B417649F3

P478

Q36252621-1C02D78F-4BB3-4F23-B545-56062A7040C1

P50

Q36252621-9AC86103-2E06-4E7F-99B3-309BC25CA90A

Q36252621-F98ECE7D-2F99-4DD5-A279-6D61A1E82FF5

P577

Q36252621-A8183BDE-9DF7-42DF-87BF-9B69852F6168

P5875

Q36252621-E2FB2F63-5025-40CB-AD41-96160BEFC964

P6179

Q36252621-C0A43C3F-0486-4F1D-B7D2-FC529E1D56B0

P698

Q36252621-F5D2BA74-8B16-400C-B9A1-DB7D73B2073B

P921

Q36252621-01E06254-4EE0-45B2-BABF-D65B6605B6D5

P932

Q36252621-FB372513-BA42-4F30-A897-9090AC2FD66C

P356

P1433

P1476

Autistic-like behaviour in Scn ...... ABA-mediated neurotransmission

@en

P2093

Chao Tai

http://www.w3.org/2001/XMLSchema#string

Christine S Cheah

http://www.w3.org/2001/XMLSchema#string

Horacio O de la Iglesia

http://www.w3.org/2001/XMLSchema#string

John L Rubenstein

http://www.w3.org/2001/XMLSchema#string

Ruth E Westenbroek

http://www.w3.org/2001/XMLSchema#string

Sung Han

http://www.w3.org/2001/XMLSchema#string

Todd Scheuer

http://www.w3.org/2001/XMLSchema#string

William A Catterall

http://www.w3.org/2001/XMLSchema#string

P2860

Advances in autism genetics: on the threshold of a new neurobiology

De novo mutations in the sodium-channel gene SCN1A cause severe myoclonic epilepsy of infancy

The Intense World Theory – A Unifying Theory of the Neurobiology of Autism

From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels

Sodium channels SCN1A, SCN2A and SCN3A in familial autism

Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy

Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy

Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation

Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations

Model of autism: increased ratio of excitation/inhibition in key neural systems

P2888

P304

385-390

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/NATURE11356

http://www.w3.org/2001/XMLSchema#string

P407

P433

7416

http://www.w3.org/2001/XMLSchema#string

P478

489

http://www.w3.org/2001/XMLSchema#string

P50

Gregory B. Potter

P577

2012-08-22T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

230721974

http://www.w3.org/2001/XMLSchema#string

P6179

1029545750

http://www.w3.org/2001/XMLSchema#string

P698

22914087

http://www.w3.org/2001/XMLSchema#string

P921

P932

3448848

http://www.w3.org/2001/XMLSchema#string