Mechanism of chloride permeation in the cystic fibrosis transmembrane conductance regulator chloride channel.
about
The ABC protein turned chloride channel whose failure causes cystic fibrosisCystic fibrosis transmembrane conductance regulator modulators in cystic fibrosis: current perspectivesDevelopment of CFTR StructureSmall molecule correctors of F508del-CFTR discovered by structure-based virtual screeningCystic fibrosis: exploiting its genetic basis in the hunt for new therapiesThe cystic fibrosis transmembrane conductance regulator (CFTR) is expressed in maturation stage ameloblasts, odontoblasts and bone cellsDual roles of the sixth transmembrane segment of the CFTR chloride channel in gating and permeation.Cystic fibrosis transmembrane conductance regulator chloride channel blockers: Pharmacological, biophysical and physiological relevance.Altered ion-responsive gene expression in Mmp20 null mice.Modeling the conformational changes underlying channel opening in CFTRMolecular modelling and molecular dynamics of CFTR.Transmembrane helical interactions in the CFTR channel pore.The CFTR ion channel: gating, regulation, and anion permeationCysteine scanning of CFTR's first transmembrane segment reveals its plausible roles in gating and permeationCharacterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR.A continuum method for determining membrane protein insertion energies and the problem of charged residues.Mutations at arginine 352 alter the pore architecture of CFTR.A mutation in CFTR modifies the effects of the adenylate kinase inhibitor Ap5A on channel gating.Enteric oxalate secretion is not directly mediated by the human CFTR chloride channel.CLC-0 and CFTR: chloride channels evolved from transporters.Cystic fibrosis transmembrane conductance regulator (ABCC7) structureApoptotic process in cystic fibrosis cells.Functional architecture of the CFTR chloride channel.Conformational changes opening and closing the CFTR chloride channel: insights from cysteine scanning mutagenesis.Architecture and functional properties of the CFTR channel pore.The search for a common structural moiety among selected pharmacological correctors of the mutant CFTR chloride channel.Tuning of CFTR chloride channel function by location of positive charges within the pore.Regulation of conductance by the number of fixed positive charges in the intracellular vestibule of the CFTR chloride channel pore.Relative movements of transmembrane regions at the outer mouth of the cystic fibrosis transmembrane conductance regulator channel pore during channel gatingRole of the juxtamembrane region of cytoplasmic loop 3 in the gating and conductance of the cystic fibrosis transmembrane conductance regulator chloride channel.Alternating access to the transmembrane domain of the ATP-binding cassette protein cystic fibrosis transmembrane conductance regulator (ABCC7).Changes in accessibility of cytoplasmic substances to the pore associated with activation of the cystic fibrosis transmembrane conductance regulator chloride channel.Cysteine-independent inhibition of the CFTR chloride channel by the cysteine-reactive reagent sodium (2-sulphonatoethyl) methanethiosulphonate.N-terminal CFTR missense variants severely affect the behavior of the CFTR chloride channel.State-dependent access of anions to the cystic fibrosis transmembrane conductance regulator chloride channel pore.On the origin of asymmetric interactions between permeant anions and the cystic fibrosis transmembrane conductance regulator chloride channel pore.Relative contribution of different transmembrane segments to the CFTR chloride channel pore.Alignment of transmembrane regions in the cystic fibrosis transmembrane conductance regulator chloride channel pore.Positive charges at the intracellular mouth of the pore regulate anion conduction in the CFTR chloride channel.Conformational changes in a pore-lining helix coupled to cystic fibrosis transmembrane conductance regulator channel gating.
P2860
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P2860
Mechanism of chloride permeation in the cystic fibrosis transmembrane conductance regulator chloride channel.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Mechanism of chloride permeati ...... ce regulator chloride channel.
@ast
Mechanism of chloride permeati ...... ce regulator chloride channel.
@en
type
label
Mechanism of chloride permeati ...... ce regulator chloride channel.
@ast
Mechanism of chloride permeati ...... ce regulator chloride channel.
@en
prefLabel
Mechanism of chloride permeati ...... ce regulator chloride channel.
@ast
Mechanism of chloride permeati ...... ce regulator chloride channel.
@en
P2860
P1476
Mechanism of chloride permeati ...... ce regulator chloride channel.
@en
P2860
P304
P356
10.1113/EXPPHYSIOL.2005.031757
P577
2005-09-12T00:00:00Z