Cytoskeletal polarization of T cells is regulated by an immunoreceptor tyrosine-based activation motif-dependent mechanism
about
Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeletonPaxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeletonEnd-binding protein 1 controls signal propagation from the T cell receptor.The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signalingThe polarity protein Par1b/EMK/MARK2 regulates T cell receptor-induced microtubule-organizing center polarizationSH3P7 is a cytoskeleton adapter protein and is coupled to signal transduction from lymphocyte antigen receptors.Kinetics and extent of protein tyrosine kinase activation in individual T cells upon antigenic stimulationComparative Anatomy of Phagocytic and Immunological SynapsesMolecular mechanisms and functional implications of polarized actin remodeling at the T cell immunological synapseProtein tyrosine kinase p53/p56(lyn) forms complexes with gamma-tubulin in rat basophilic leukemia cellsCentrosome repositioning in T cells is biphasic and driven by microtubule end-on capture-shrinkage.CD2 molecules redistribute to the uropod during T cell scanning: implications for cellular activation and immune surveillance.Recruitment of dynein to the Jurkat immunological synapseMTOC reorientation occurs during FcgammaR-mediated phagocytosis in macrophages.T-cell antagonism by short half-life pMHC ligands can be mediated by an efficient trapping of T-cell polarization toward the APCProteomic characterization of plasma membrane-proximal T cell activation responses.A cascade of protein kinase C isozymes promotes cytoskeletal polarization in T cells.INF2 promotes the formation of detyrosinated microtubules necessary for centrosome reorientation in T cellsProtein kinase Cdelta regulates antigen receptor-induced lytic granule polarization in mouse CD8+ CTLHematopoietic lineage cell-specific protein 1 is recruited to the immunological synapse by IL-2-inducible T cell kinase and regulates phospholipase Cgamma1 Microcluster dynamics during T cell spreadingCD81 controls sustained T cell activation signaling and defines the maturation stages of cognate immunological synapses.A model for the interplay of receptor recycling and receptor-mediated contact in T cellsHIV-1 Nef employs two distinct mechanisms to modulate Lck subcellular localization and TCR induced actin remodeling.An experimental and computational study of effects of microtubule stabilization on T-cell polarityWASp-dependent actin cytoskeleton stability at the dendritic cell immunological synapse is required for extensive, functional T cell contacts.Centrosome docking at the immunological synapse is controlled by Lck signaling.The adapter proteins LAT and SLP-76 are required for T-cell activation.Symmetry, stability, and reversibility properties of idealized confined microtubule cytoskeletons.The regulation of actin remodeling during T-cell-APC conjugate formation.Regulation of microtubule-organizing center orientation and actomyosin cytoskeleton rearrangement during immune interactions.Changes in actin dynamics at the T-cell/APC interface: implications for T-cell anergy?Membrane-cytoskeleton interactions during the formation of the immunological synapse and subsequent T-cell activation.Visualization of signaling pathways and cortical cytoskeleton in cytolytic and noncytolytic natural killer cell immune synapses.Leukocyte uropod formation and membrane/cytoskeleton linkage in immune interactions.GSK3-mediated instability of tubulin polymers is responsible for the failure of immature CD4+CD8+ thymocytes to polarize their MTOC in response to TCR stimulationLymphocyte polarity, the immunological synapse and the scope of biological analogy.Casein kinase I delta controls centrosome positioning during T cell activationHydrogen sulfide is an endogenous potentiator of T cell activation.Retroviral spread by induction of virological synapses.Gelsolin overexpression alters actin dynamics and tyrosine phosphorylation of lipid raft-associated proteins in Jurkat T cells.
P2860
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P2860
Cytoskeletal polarization of T cells is regulated by an immunoreceptor tyrosine-based activation motif-dependent mechanism
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
Cytoskeletal polarization of T ...... tion motif-dependent mechanism
@ast
Cytoskeletal polarization of T ...... tion motif-dependent mechanism
@en
type
label
Cytoskeletal polarization of T ...... tion motif-dependent mechanism
@ast
Cytoskeletal polarization of T ...... tion motif-dependent mechanism
@en
prefLabel
Cytoskeletal polarization of T ...... tion motif-dependent mechanism
@ast
Cytoskeletal polarization of T ...... tion motif-dependent mechanism
@en
P2093
P2860
P356
P1476
Cytoskeletal polarization of T ...... tion motif-dependent mechanism
@en
P2093
Lowin-Kropf B
Shapiro VS
P2860
P304
P356
10.1083/JCB.140.4.861
P407
P577
1998-02-01T00:00:00Z