Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells.
about
Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domainDistinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domainsCharacterization of an interaction between insulin receptor substrate 1 and the insulin receptor by using the two-hybrid systemCross talk of pp125(FAK) and pp59(Lyn) non-receptor tyrosine kinases to insulin-mimetic signaling in adipocytesTyr624 and Tyr628 in insulin receptor substrate-2 mediate its association with the insulin receptorErythropoietin induces the tyrosine phosphorylation of insulin receptor substrate-2. An alternate pathway for erythropoietin-induced phosphatidylinositol 3-kinase activationInteraction of insulin receptor substrate-2 (IRS-2) with the insulin and insulin-like growth factor I receptors. Evidence for two distinct phosphotyrosine-dependent interaction domains within IRS-2Interleukin-9 induces tyrosine phosphorylation of insulin receptor substrate-1 via JAK tyrosine kinasesGrowth hormone, interferon-gamma, and leukemia inhibitory factor utilize insulin receptor substrate-2 in intracellular signalingConsequences of Stat6 deletion on Sis/PDGF- and IL-4-induced proliferation and transcriptional activation in murine fibroblastsThe Fyn tyrosine kinase binds Irs-1 and forms a distinct signaling complex during insulin stimulationInterferon-alpha engages the insulin receptor substrate-1 to associate with the phosphatidylinositol 3'-kinaseJanus kinase-dependent activation of insulin receptor substrate 1 in response to interleukin-4, oncostatin M, and the interferonsTyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15Interactions of Cbl with Grb2 and phosphatidylinositol 3'-kinase in activated Jurkat cells.Role of IRS-1-GRB-2 complexes in insulin signaling.Cytokines in asthma.CD30 ligand (CD30L)-expressing acute myeloid leukemias: a new model of paracrine interactions for the regulation of blast cells proliferation.The adaptor protein insulin receptor substrate 2 inhibits alternative macrophage activation and allergic lung inflammationInsulin-like growth factor I synergizes with interleukin 4 for hematopoietic cell proliferation independent of insulin receptor substrate expression.Similarities and differences in signal transduction by interleukin 4 and interleukin 13: analysis of Janus kinase activationInterleukin 4 signals through two related pathwaysBrain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity.Insulin-dependent tyrosine phosphorylation of the vav protooncogene product in cells of hematopoietic origin.Regulation of interleukin 4-mediated signaling by naturally occurring dominant negative and attenuated forms of human Stat6.Interleukin 4 receptor signaling in human monocytes and U937 cells involves the activation of a phosphatidylcholine-specific phospholipase C: a comparison with chemotactic peptide, FMLP, phospholipase D, and sphingomyelinase.Transient inhibition of interleukin 4 signaling by T cell receptor ligation.Molecular cloning of an amphibian insulin receptor substrate 1-like cDNA and involvement of phosphatidylinositol 3-kinase in insulin-induced Xenopus oocyte maturation.Insulin receptor substrate 1 rescues insulin action in CHO cells expressing mutant insulin receptors that lack a juxtamembrane NPXY motif.The Drosophila insulin receptor activates multiple signaling pathways but requires insulin receptor substrate proteins for DNA synthesis.Enhancement or inhibition of insulin signaling by insulin receptor substrate 1 is cell context dependent.Immune-mediated signaling in intestinal goblet cells via PI3-kinase- and AKT-dependent pathways.Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis.Characterization of the interleukin-4 nuclear activated factor/STAT and its activation independent of the insulin receptor substrate proteins.Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice.Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes.An interleukin (IL)-13 receptor lacking the cytoplasmic domain fails to transduce IL-13-induced signals and inhibits responses to IL-4.Activation of phosphatidylinositol 3-kinase by interleukin-13. An inhibitory signal for inducible nitric-oxide synthase expression in epithelial cell line HT-29.Jak1 expression is required for mediating interleukin-4-induced tyrosine phosphorylation of insulin receptor substrate and Stat6 signaling molecules.
P2860
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P2860
Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
1993年學術文章
@zh
1993年學術文章
@zh-hant
name
Common elements in interleukin ...... dependent hematopoietic cells.
@ast
Common elements in interleukin ...... dependent hematopoietic cells.
@en
type
label
Common elements in interleukin ...... dependent hematopoietic cells.
@ast
Common elements in interleukin ...... dependent hematopoietic cells.
@en
prefLabel
Common elements in interleukin ...... dependent hematopoietic cells.
@ast
Common elements in interleukin ...... dependent hematopoietic cells.
@en
P2093
P2860
P356
P1476
Common elements in interleukin ...... -dependent hematopoietic cells
@en
P2093
A D Keegan
G E Lienhard
S A Aaronson
P2860
P304
P356
10.1073/PNAS.90.9.4032
P407
P577
1993-05-01T00:00:00Z