Life in the balance: how BH3-only proteins induce apoptosis. - Wikidata - awgldk - TriplyDB

Life in the balance: how BH3-only proteins induce apoptosis.

Life in the balance: how BH3-only proteins induce apoptosis.

http://www.wikidata.org/entity/Q36294226

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The transcriptional cofactor TRIM33 prevents apoptosis in B lymphoblastic leukemia by deactivating a single enhancer Two independent positive feedbacks and bistability in the Bcl-2 apoptotic switch Noxa/Bcl-2 protein interactions contribute to bortezomib resistance in human lymphoid cells Human Bop is a novel BH3-only member of the Bcl-2 protein family ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL BimL directly neutralizes Bcl-xL to promote Bax activation during UV-induced apoptosis The vaccinia virus protein F1L interacts with Bim and inhibits activation of the pro-apoptotic protein Bax The hepatitis C virus core protein contains a BH3 domain that regulates apoptosis through specific interaction with human Mcl-1 A short Nur77-derived peptide converts Bcl-2 from a protector to a killer Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress The Bcl-2 apoptotic switch in cancer development and therapy Phosphorylation of Puma modulates its apoptotic function by regulating protein stability Glucose metabolism attenuates p53 and Puma-dependent cell death upon growth factor deprivation The BH3-only protein Puma plays an essential role in cytokine deprivation induced apoptosis of mast cells mir-29 regulates Mcl-1 protein expression and apoptosis Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction Inhibition of ubiquitin-mediated degradation of MOAP-1 by apoptotic stimuli promotes Bax function in mitochondria Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis Potential of apoptotic pathway-targeted cancer therapeutic research: Where do we stand?Regulation of Bim in Health and Disease Mitochondria and the autophagy-inflammation-cell death axis in organismal aging Bim and Bmf synergize to induce apoptosis in Neisseria gonorrhoeae infection Host-Cell Survival and Death During Chlamydia Infection Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation Determinants of BH3 Binding Specificity for Mcl-1 versus Bcl-xL Rational Design of Proteolytically Stable, Cell-Permeable Peptide-Based Selective Mcl-1 Inhibitors The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist Inhibition of Apoptosis and NF-κB Activation by Vaccinia Protein N1 Occur via Distinct Binding Surfaces and Make Different Contributions to Virulence Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains MicroRNA-221 targets Bmf in hepatocellular carcinoma and correlates with tumor multifocality Puma joins the battery of BH3-only proteins that promote death and infarction during myocardial ischemia Cytoprotection by the modulation of mitochondrial electron transport chain: the emerging role of mitochondrial STAT3 The combination of BH3-mimetic ABT-737 with the alkylating agent temozolomide induces strong synergistic killing of melanoma cells independent of p53 Regulation of the lifespan in dendritic cell subsets Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion via regulation of Bim Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene Estrogen-mediated upregulation of Noxa is associated with cell cycle progression in estrogen receptor-positive breast cancer cells Maternal exposure to polycyclic aromatic hydrocarbons diminishes murine ovarian reserve via induction of Harakiri

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Life in the balance: how BH3-only proteins induce apoptosis.

http://www.wikidata.org/entity/Q36294226

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2005 nî lūn-bûn

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2005年の論文

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年學術文章

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2005年學術文章

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2005年學術文章

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Life in the balance: how BH3-only proteins induce apoptosis.

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Life in the balance: how BH3-only proteins induce apoptosis.

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Life in the balance: how BH3-only proteins induce apoptosis.

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Life in the balance: how BH3-only proteins induce apoptosis.

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Simon N Willis

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P2860

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis

p53 has a direct apoptogenic role at the mitochondria

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.

Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

PUMA couples the nuclear and cytoplasmic proapoptotic function of p53

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.

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apoptotic process

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