A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death.
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Serglycin-deficient cytotoxic T lymphocytes display defective secretory granule maturation and granzyme B storagePerforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosisAutophagy induced by conventional chemotherapy mediates tumor cell sensitivity to immunotherapy.Chemotherapy enhances tumor cell susceptibility to CTL-mediated killing during cancer immunotherapy in mice.Perforin enhances the granulysin-induced lysis of Listeria innocua in human dendritic cells.Cationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells.Granzyme A activates another way to dieCytotoxic and non-cytotoxic roles of the CTL/NK protease granzyme B.Discordant regulation of granzyme H and granzyme B expression in human lymphocytes.Death by a thousand cuts: granzyme pathways of programmed cell deathIntracellular versus extracellular granzyme B in immunity and disease: challenging the dogma.Endocytosing the death sentenceRadiation-induced autophagy potentiates immunotherapy of cancer via up-regulation of mannose 6-phosphate receptor on tumor cells in mice.Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis.Mechanisms of granule-dependent killing.The battlefield of perforin/granzyme cell death pathways.Expression of multiple granzymes by cytotoxic T lymphocyte implies that they activate diverse apoptotic pathways in target cells.Mechanism of synergistic effect of chemotherapy and immunotherapy of cancer.Controversies in granzyme biology.Novel mechanism of synergistic effects of conventional chemotherapy and immune therapy of cancer.Human purified CD8+ T cells: Ex vivo expansion model to generate a maximum yield of functional cytotoxic cells.Cell binding, internalization and cytotoxic activity of human granzyme B expressed in the yeast Pichia pastoris.Granule-mediated killing by granzyme B and perforin requires a mannose 6-phosphate receptor and is augmented by cell surface heparan sulfate.Killing of target cells by redirected granzyme B in the absence of perforin.Granzyme-mediated cytotoxicity does not involve the mannose 6-phosphate receptors on target cells.Granzyme B encoded by the commonly occurring human RAH allele retains pro-apoptotic activity.Granzymes in cytolytic lymphocytes--to kill a killer?A central role for Bid in granzyme B-induced apoptosis.A novel mechanism for protein delivery: granzyme B undergoes electrostatic exchange from serglycin to target cells.Granzyme B deficiency promotes osteoblastic differentiation and calcification of vascular smooth muscle cells in hypoxic pulmonary hypertension.
P2860
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P2860
A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
A clathrin/dynamin- and mannos ...... granzyme B-induced cell death.
@ast
A clathrin/dynamin- and mannos ...... granzyme B-induced cell death.
@en
type
label
A clathrin/dynamin- and mannos ...... granzyme B-induced cell death.
@ast
A clathrin/dynamin- and mannos ...... granzyme B-induced cell death.
@en
prefLabel
A clathrin/dynamin- and mannos ...... granzyme B-induced cell death.
@ast
A clathrin/dynamin- and mannos ...... granzyme B-induced cell death.
@en
P2093
P2860
P356
P1476
A clathrin/dynamin- and mannos ...... granzyme B-induced cell death.
@en
P2093
Christopher J Froelich
David A Jans
Joseph A Trapani
Kevin Y T Thia
Kylie A Browne
Mauro S Sandrin
Vivien R Sutton
P2860
P304
P356
10.1083/JCB.200210150
P407
P577
2003-01-21T00:00:00Z