Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation. - Wikidata - awgldk - TriplyDB

Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation.

Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation.

http://www.wikidata.org/entity/Q36322979

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Bub3 is a spindle assembly checkpoint protein regulating chromosome segregation during mouse oocyte meiosis The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions.RAE-1, a novel PHR binding protein, is required for axon termination and synapse formation in Caenorhabditis elegans Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint.The role of aneuploidy in promoting and suppressing tumors Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers When 2+2=5: the origins and fates of aneuploid and tetraploid cells Structural analysis of Bub3 interactions in the mitotic spindle checkpoint Nup358 integrates nuclear envelope breakdown with kinetochore assembly Rae1 interaction with NuMA is required for bipolar spindle formation Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis Mad2 overexpression promotes aneuploidy and tumorigenesis in mice The PHR proteins: intracellular signaling hubs in neuronal development and axon degeneration Tissue Regeneration in the Chronically Inflamed Tumor Environment: Implications for Cell Fusion Driven Tumor Progression and Therapy Resistant Tumor Hybrid Cells Connecting the speckles: Splicing kinases and their role in tumorigenesis and treatment response Aurora B hyperactivation by Bub1 overexpression promotes chromosome missegregation Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation Defining the Molecular Basis of BubR1 Kinetochore Interactions and APC/C-CDC20 Inhibition Nuclear export of the yeast mRNA-binding protein Nab2 is linked to a direct interaction with Gfd1 and to Gle1 function.Building up the nucleus: nuclear organization in the establishment of totipotency and pluripotency during mammalian development Nuclear pore proteins and the control of genome functions Role of cell cycle regulators in lung carcinogenesis Drosophila CENP-A mutations cause a BubR1-dependent early mitotic delay without normal localization of kinetochore components Spindle assembly checkpoint regulates mitotic cell cycle progression during preimplantation embryo development Nuclear pore composition regulates neural stem/progenitor cell differentiation in the mouse embryo USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis Colonic tumorigenesis in BubR1+/-ApcMin/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability Overexpression of ubiquitin specific protease 44 (USP44) induces chromosomal instability and is frequently observed in human T-cell leukemia Inactivating the spindle checkpoint kinase Bub1 during embryonic development results in a global shutdown of proliferation Separase loss of function cooperates with the loss of p53 in the initiation and progression of T- and B-cell lymphoma, leukemia and aneuploidy in mice Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice.In vivo dynamics of Drosophila nuclear envelope components.TAp73 regulates the spindle assembly checkpoint by modulating BubR1 activity Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisons RED, a spindle pole-associated protein, is required for kinetochore localization of MAD1, mitotic progression, and activation of the spindle assembly checkpoint.Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery.Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma.

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P2860

Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation.

http://www.wikidata.org/entity/Q36322979

description

2003 nî lūn-bûn

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2003年の論文

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年學術文章

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2003年學術文章

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name

Rae1 is an essential mitotic c ...... ent chromosome missegregation.

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Rae1 is an essential mitotic c ...... ent chromosome missegregation.

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type

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Rae1 is an essential mitotic c ...... ent chromosome missegregation.

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Rae1 is an essential mitotic c ...... ent chromosome missegregation.

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prefLabel

Rae1 is an essential mitotic c ...... ent chromosome missegregation.

@ast

Rae1 is an essential mitotic c ...... ent chromosome missegregation.

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Journal of Cell Biology

P1476

Rae1 is an essential mitotic c ...... ent chromosome missegregation.

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P2093

Darren J Baker

http://www.w3.org/2001/XMLSchema#string

J Ramesh Babu

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Jan M van Deursen

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Karthik B Jeganathan

http://www.w3.org/2001/XMLSchema#string

Ningling Kang-Decker

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Xiaosheng Wu

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P2860

RAE1 is a shuttling mRNA export factor that binds to a GLEBS-like NUP98 motif at the nuclear pore complex through multiple domains

Characterization of MAD2B and other mitotic spindle checkpoint genes

The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase

Mutations of mitotic checkpoint genes in human cancers

mRNA binding protein mrnp 41 localizes to both nucleus and cytoplasm

TAP binds to the constitutive transport element (CTE) through a novel RNA-binding motif that is sufficient to promote CTE-dependent RNA export from the nucleus

The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates

The Ct-RAE1 protein interacts with Balbiani ring RNP particles at the nuclear pore.

Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex

Mex67p of Schizosaccharomyces pombe interacts with Rae1p in mediating mRNA export

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10930734

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12551952

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2172680

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