Internalization of interleukin 2 is mediated by the beta chain of the high-affinity interleukin 2 receptor
about
Characterization of the interleukin 2 receptor beta chain using three distinct monoclonal antibodiesUtilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15Cloning and characterization of deer mouse (Peromyscus maniculatus) cytokine and chemokine cDNAsDuck (Anas platyrhynchos), Japanese quail (Coturnix coturnix japonica) and other avian interleukin-2 reveals significant conservation of gene organization, promoter elements and functional residues.Identification of specific residues of human interleukin 2 that affect binding to the 70-kDa subunit (p70) of the interleukin 2 receptor.Interleukin 1 is an autocrine regulator of human endothelial cell growth.Mitogenicity and down-regulation of high-affinity interleukin 2 receptor by YTA-1 and YTA-2, monoclonal antibodies that recognize 75-kDa molecules on human large granular lymphocytes.Production of granulocyte/macrophage-colony-stimulating factor by human natural killer cells. Modulation by the p75 subunit of the interleukin 2 receptor and by the CD2 receptor.Expression of functional interleukin 2 receptors by peripheral blood monocytes from patients with active pulmonary tuberculosis.Inability of mitogen-activated lymphocytes obtained from patients with malignant primary intracranial tumors to express high affinity interleukin 2 receptors.Differential regulation of lymphokine production by distinct subunits of the T cell interleukin 2 receptorInterleukin-2 receptor-directed immunosuppressive therapies: antibody- or cytokine-based targeting molecules.Decreased proliferation, interleukin 2 synthesis, and interleukin 2 receptor expression are accompanied by decreased mRNA expression in phytohemagglutinin-stimulated cells from elderly donorsExpression of p55 (Tac) interleukin-2 receptor (IL-2R), but not p75 IL-2R, in cultured H-RS cells and H-RS cells in tissues.Functional role of IL-2 receptors on tumour-infiltrating lymphocytes.Affinity of IL-2 receptors and proliferation of mitogen activated lymphocytes in Hodgkin's diseaseMurine T-lymphocyte proliferation induced by interleukin 2 correlates with a transient increase in p56lck kinase activity and the tyrosine phosphorylation of a 97-kDa protein.Characterization of the interleukin 2 receptors (IL-2R) expressed on human natural killer cells activated in vivo by IL-2: association of the p64 IL-2R gamma chain with the IL-2R beta chain in functional intermediate-affinity IL-2R.Cyclosporin A inhibition of interleukin 2 gene expression, but not natural killer cell proliferation, after interferon induction in vivo.Increased expression of the interleukin 2 (IL-2) receptor beta chain (p70) on CD56+ natural killer cells after in vivo IL-2 therapy: p70 expression does not alone predict the level of intermediate affinity IL-2 binding.The interleukin 2 receptor. Functional consequences of its bimolecular structureInterleukin 2 receptor-targeted cytotoxicity. Interleukin 2 receptor-mediated action of a diphtheria toxin-related interleukin 2 fusion proteinInteractions between receptors for interleukin 2 and interleukin 4 on lines of helper T cells (HT-2) and B lymphoma cells (BCL1).Interleukin-2 triggers a novel phosphatidylinositol 3-kinase-dependent MEK activation pathway.IL-2Rα mediates temporal regulation of IL-2 signaling and enhances immunotherapy.Ligand-stimulated tyrosine phosphorylation of the IL-2 receptor beta chain and receptor-associated proteins.Interleukin (IL)-2 and IL-3 induce distinct but overlapping responses in murine IL-3-dependent 32D cells transduced with human IL-2 receptor beta chain: involvement of tyrosine kinase(s) other than p56lck.Immunotoxins and cytokine toxin fusion proteins.Protein engineering of DAB-IL-2 fusion toxins to increase biologic potency.Human fusion proteins between interleukin 2 and IgM heavy chain are cytotoxic for cells expressing the interleukin 2 receptor.The immunotherapy of human cancer with interleukin 2: present status and future directions.Localization in human interleukin 2 of the binding site to the alpha chain (p55) of the interleukin 2 receptorEvidence for additional subunits associated to the mouse interleukin 2 receptor p55/p75 complexChimeric fusion proteins used for therapy: indications, mechanisms, and safety.Differential growth requirements and effector functions of alpha/beta and gamma/delta human T cells.An overview of the human interleukin-2 receptor: molecular, biochemical, and functional properties.Theoretical and practical aspects of B-cell activation: murine and human systems.Surface proteins and glycoproteins of human leucocytes.Human T-cell precursors: involvement of the IL-2 pathway in the generation of mature T cells.Lymphocyte motility and lymphocyte chemoattractant factors.
P2860
Q24293092-813FA267-2C6A-4E39-8B24-9A991D65F47AQ24595192-836C577C-52CD-4C32-AD7A-5F9758A6C722Q24794115-C94D9DD9-677B-445D-8F90-96B8034E894EQ30351972-8B7A1C0C-865A-4B1C-BBDE-A791226C4458Q33656209-C8343A06-7C2B-4F04-81CF-CD863A55429EQ33757605-D435B288-4D29-429D-95B9-78FC9024C18DQ33838426-D1350461-7F9B-44D4-BAD6-84E4F1D1FBCAQ34225129-A2CB2035-DA54-47B4-9D00-7A7EC89451C3Q34252586-A2898AAC-78EA-42E4-AF66-A84AE6B402C4Q34255250-20BD0E4E-4EDC-4401-A7BE-A51A9FFD6A38Q34265069-15CCC46A-1772-4C75-9557-CEDEA6CBF1A5Q35595871-04A9D2CA-FAC0-4F9E-B072-F94E1D9458A4Q35811149-507C39D4-3297-4882-9236-E7C9416A0C96Q35811874-36D9B586-3FC5-465D-9E4E-D67B0C591C9DQ35979219-2EC4F889-CDE5-4CF1-96C1-E67984EB9D9EQ35981410-6952E6D3-EA4B-4F14-AFB2-33EEE5399636Q36225768-BC078179-5A14-4157-8797-DA60EF919A2BQ36231652-F5F8E553-2144-4335-A8BE-188DD6EAA809Q36350653-578B242B-B758-464E-9549-6F3D6CA41B59Q36353604-111218F6-C9F0-4534-A74A-8F5BABBA8648Q36354051-E78C5668-A29F-45B0-AD90-83B88374780DQ36354517-F3301088-2767-4748-B284-EB4833BF75B9Q36355965-CA7C24A6-F2A2-41F6-8B2C-C61431A21475Q36551314-5EB9878F-D698-4573-AB6B-91A7FAF1613EQ36722289-69012B2F-A55C-4B52-9FA3-5E83554974E8Q36741909-CFE1DD40-5710-4444-8ABB-BA4923AAE0CDQ36921940-629C86A4-FFB1-4768-84BF-BD56DA99D7EAQ36968800-6DCE1A4C-DE8F-4892-BD5E-E1EF48849588Q36968818-4F0BA8DC-14FC-4F09-A82C-C76124595E5CQ37319417-F8664ED3-322B-4916-A651-1DE2E7CC7AB7Q37427683-7356F7B6-1931-4520-8385-85D856E7157CQ37519286-720CEB6C-BB8F-4257-8B5F-0CE59C719F6CQ37654897-CDC7FE51-C184-433D-9086-7C0460FFBB6CQ38400396-E5FD4089-87B1-4681-846F-E10A77D2FFCCQ38774876-4264B1B4-9353-44C0-9322-C2D0E8349B01Q39464471-2F305ACE-5A7C-45EE-9ED9-7ED80D32F651Q39483737-720EC3B4-2E8D-47CB-89E8-F83A2DE289A5Q39524176-94428009-A091-4A58-8148-84CDD57D8D48Q39526456-05D335CB-3BFC-4032-A1EE-6A5576F08B99Q39564207-B3206957-C249-4D35-AAC6-F9ECA7C4FB7E
P2860
Internalization of interleukin 2 is mediated by the beta chain of the high-affinity interleukin 2 receptor
description
1987 nî lūn-bûn
@nan
1987年の論文
@ja
1987年学术文章
@wuu
1987年学术文章
@zh-cn
1987年学术文章
@zh-hans
1987年学术文章
@zh-my
1987年学术文章
@zh-sg
1987年學術文章
@yue
1987年學術文章
@zh
1987年學術文章
@zh-hant
name
Internalization of interleukin ...... ffinity interleukin 2 receptor
@ast
Internalization of interleukin ...... ffinity interleukin 2 receptor
@en
type
label
Internalization of interleukin ...... ffinity interleukin 2 receptor
@ast
Internalization of interleukin ...... ffinity interleukin 2 receptor
@en
prefLabel
Internalization of interleukin ...... ffinity interleukin 2 receptor
@ast
Internalization of interleukin ...... ffinity interleukin 2 receptor
@en
P2860
P356
P1476
Internalization of interleukin ...... ffinity interleukin 2 receptor
@en
P2093
P2860
P304
P356
10.1084/JEM.165.4.1201
P407
P577
1987-04-01T00:00:00Z