Localization in human interleukin 2 of the binding site to the alpha chain (p55) of the interleukin 2 receptor
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Definition and spatial location of mouse interleukin-2 residues that interact with its heterotrimeric receptorBinding of small molecules to an adaptive protein-protein interfaceIdentification of an interleukin-15alpha receptor-binding site on human interleukin-15Small-molecule inhibitors of protein-protein interactions: progressing towards the dreamConstruction, purification, and characterization of a chimeric TH1 antagonist.The first alpha helix of interleukin (IL)-2 folds as a homotetramer, acts as an agonist of the IL-2 receptor beta chain, and induces lymphokine-activated killer cellsCooperative interactions between the interleukin 2 receptor alpha and beta chains alter the interleukin 2-binding affinity of the receptor subunits.Small molecules, big targets: drug discovery faces the protein-protein interaction challenge.Identification of a direct interaction between interleukin 2 and the p64 interleukin 2 receptor gamma chain.Hematopoietic cytokines: similarities and differences in the structures, with implications for receptor binding.Structure-function studies of interleukin 15 using site-specific mutagenesis, polyethylene glycol conjugation, and homology modeling.The interleukin 2 receptor (IL-2R): the IL-2R alpha subunit alters the function of the IL-2R beta subunit to enhance IL-2 binding and signaling by mechanisms that do not require binding of IL-2 to IL-2R alpha subunit.High efficacy vasopermeability drug candidates identified by screening in an ex ovo chorioallantoic membrane model.Discovery of multiple interacting partners of gankyrin, a proteasomal chaperone and an oncoprotein--evidence for a common hot spot site at the interface and its functional relevance.Structural analysis and modeling of a synthetic interleukin-2 mimetic and its interleukin-2Rbeta2 receptor.Carbohydrate recognition site of interleukin-2 in relation to cell proliferation.Two distinct functional sites of human interleukin 4 are identified by variants impaired in either receptor binding or receptor activation.DAB389 interleukin-2 receptor binding domain mutations. Cytotoxic probes for studies of ligand-receptor interactions.Identification of three adjacent amino acids of interleukin-2 receptor beta chain which control the affinity and the specificity of the interaction with interleukin-2.Mutation of Asp20 of human interleukin-2 reveals a dual role of the p55 alpha chain of the interleukin-2 receptor.Interleukin-2 induces gamma-S-adenosyl-L-methionine synthetase gene expression during T-lymphocyte activationNMR characterization of interleukin-2 in complexes with the IL-2Ralpha receptor component, and with low molecular weight compounds that inhibit the IL-2/IL-Ralpha interaction.Interleukin-2 carbohydrate recognition modulates CTLL-2 cell proliferation.
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P2860
Localization in human interleukin 2 of the binding site to the alpha chain (p55) of the interleukin 2 receptor
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on June 1991
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Localization in human interleu ...... of the interleukin 2 receptor
@en
Localization in human interleukin 2 of the binding site to the alpha chain
@nl
type
label
Localization in human interleu ...... of the interleukin 2 receptor
@en
Localization in human interleukin 2 of the binding site to the alpha chain
@nl
prefLabel
Localization in human interleu ...... of the interleukin 2 receptor
@en
Localization in human interleukin 2 of the binding site to the alpha chain
@nl
P2093
P2860
P356
P1476
Localization in human interleu ...... of the interleukin 2 receptor
@en
P2093
Campbell E
P2860
P304
P356
10.1073/PNAS.88.11.4636
P407
P577
1991-06-01T00:00:00Z