Isolation and characterization of a light chain variable region gene for human rheumatoid factors
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Rheumatoid factors isolated from patients with autoimmune disorders are derived from germline genes distinct from those encoding the Wa, Po, and Bla cross-reactive idiotypes.A highly informative probe for two polymorphic Vh gene regions that contain one or more autoantibody-associated Vh genesEvidence that the V kappa III gene usage is nonstochastic in both adult and newborn peripheral B cells and that peripheral CD5+ adult B cells are oligoclonal.The complete nucleotide sequences of the heavy chain variable regions of six monospecific rheumatoid factors derived from Epstein-Barr virus-transformed B cells isolated from the synovial tissue of patients with rheumatoid arthritis. Further evidencNucleotidic sequence analysis of the variable domains of four human monoclonal IgM with an antibody activity to myelin-associated glycoprotein.Idiotypic and subgroup analysis of human monoclonal rheumatoid factors. Implications for structural and genetic basis of autoantibodies in humans.Autoantibody activity and V gene usage by B-cell malignancies.Immunoglobulin V gene expression in CD5 B-cell malignancies.The antigen-binding domain of a human IgG-anti-F(ab')2 autoantibody.Molecular characteristics of antibodies bearing an anti-DNA-associated idiotype.Genetic analysis of self-associating immunoglobulin G rheumatoid factors from two rheumatoid synovia implicates an antigen-driven responseComplete sequence of the genes encoding the VH and VL regions of low- and high-affinity monoclonal IgM and IgA1 rheumatoid factors produced by CD5+ B cells from a rheumatoid arthritis patient.Expression of a public idiotype by human monoclonal IgM directed to myelin-associated glycoprotein and characterization of the variability subgroup of their heavy and light chains.Human immunoglobulin (IgG) induced deletion of IgM rheumatoid factor B cells in transgenic mice.Nonstochastic pairing of immunoglobulin heavy and light chains expressed by chronic lymphocytic leukemia B cells is predicated on the heavy chain CDR3.Rheumatoid factors from patients with rheumatoid arthritis react with beta 2-microglobulin.Human anti-self antibodies with high specificity from phage display libraries.Influence of the light chain repertoire on immunoglobulin genes encoding thyroid autoantibody Fab from combinatorial libraries.From human autoantibodies to the fetal antibody repertoire to B cell malignancy: it's a small world after all.Delineating the synovial fluid proteome: recent advancements and ongoing challenges in biomarker research.The molecular origin of anti-DNA antibodies.Polymorphisms of immunologically relevant loci in human disease. Autoimmunity and human heavy chain variable regions.The structural repertoire of the human V kappa domainMolecular and cellular mechanisms of joint destruction in rheumatoid arthritis: two cellular mechanisms explain joint destruction?Germline variable region gene segment derivation of human monoclonal anti-Rh(D) antibodies. Evidence for affinity maturation by somatic hypermutation and repertoire shift.Hepatitis C virus and non-Hodgkin's lymphomas.VH and V kappa segment structure of anti-insulin IgG autoantibodies in patients with insulin-dependent diabetes mellitus. Evidence for somatic selection.Rheumatoid factors: where are we now?Immunocytochemical detection of kappa and lambda light chain V region subgroups in human B-cell malignancies.Function of B cells expressing a human immunoglobulin M rheumatoid factor autoantibody in transgenic mice.Immunoglobulin Gene Rearrangement and Expression in B-CLL.
P2860
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P2860
Isolation and characterization of a light chain variable region gene for human rheumatoid factors
description
1987 nî lūn-bûn
@nan
1987年の論文
@ja
1987年学术文章
@wuu
1987年学术文章
@zh-cn
1987年学术文章
@zh-hans
1987年学术文章
@zh-my
1987年学术文章
@zh-sg
1987年學術文章
@yue
1987年學術文章
@zh
1987年學術文章
@zh-hant
name
Isolation and characterization ...... e for human rheumatoid factors
@ast
Isolation and characterization ...... e for human rheumatoid factors
@en
type
label
Isolation and characterization ...... e for human rheumatoid factors
@ast
Isolation and characterization ...... e for human rheumatoid factors
@en
prefLabel
Isolation and characterization ...... e for human rheumatoid factors
@ast
Isolation and characterization ...... e for human rheumatoid factors
@en
P2093
P2860
P356
P1476
Isolation and characterization ...... e for human rheumatoid factors
@en
P2093
P2860
P304
P356
10.1084/JEM.166.6.1900
P407
P577
1987-12-01T00:00:00Z