CD4 down-regulation by nef alleles isolated from human immunodeficiency virus type 1-infected individuals.
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HIV-1 Nef binds the DOCK2-ELMO1 complex to activate rac and inhibit lymphocyte chemotaxisMechanism for down-regulation of CD28 by Nef.Human immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tailCo-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulationHuman immunodeficiency virus type 1 Nef associates with a cellular serine kinase in T lymphocytesNef-mediated clathrin-coated pit formationThe association of Nef with a cellular serine/threonine kinase and its enhancement of infectivity are viral isolate dependentLentivirus Nef specifically activates Pak2.A consensus surface activation marker signature is partially dependent on human immunodeficiency virus type 1 Nef expression within productively infected macrophagesSimian immunodeficiency virus containing mutations in N-terminal tyrosine residues and in the PxxP motif in Nef replicates efficiently in rhesus macaques.Conservation of the central proline-rich (PxxP) motifs of human immunodeficiency virus type 1 Nef protein during the disease progression in two hemophiliac patients.The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes.Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef.Design and use of an inducibly activated human immunodeficiency virus type 1 Nef to study immune modulation.HIV's Nef interacts with β-catenin of the Wnt signaling pathway in HEK293 cellsThe proteolytic cleavage of human immunodeficiency virus type 1 Nef does not correlate with its ability to stimulate virion infectivity.Tat protein induces human immunodeficiency virus type 1 (HIV-1) coreceptors and promotes infection with both macrophage-tropic and T-lymphotropic HIV-1 strains.Sequence variations in human immunodeficiency virus type 1 Nef are associated with different stages of disease.Genetic and functional diversity of human immunodeficiency virus type 1 subtype B Nef primary isolatesCD4 down-modulation by human immunodeficiency virus type 1 Nef correlates with the efficiency of viral replication and with CD4(+) T-cell depletion in human lymphoid tissue ex vivoHuman immunodeficiency virus type 1 Nef-induced CD4 cell surface downregulation is inhibited by ikarugamycinMyristoylation: An Important Protein Modification in the Immune ResponseRestoration of wild-type infectivity to human immunodeficiency virus type 1 strains lacking nef by intravirion reverse transcription.Two elements target SIV Nef to the AP-2 clathrin adaptor complex, but only one is required for the induction of CD4 endocytosis.The functions of the HIV1 protein Vpr and its action through the DCAF1.DDB1.Cullin4 ubiquitin ligase.Simian and human immunodeficiency virus Nef proteins use different surfaces to downregulate class I major histocompatibility complex antigen expression.Nef proteins from diverse groups of primate lentiviruses downmodulate CXCR4 to inhibit migration to the chemokine stromal derived factor 1.Impaired regulation of HLA-DR expression in human immunodeficiency virus-infected monocytes.OrfA downregulates feline immunodeficiency virus primary receptor CD134 on the host cell surface and is important in viral infection.Simian immunodeficiency virus Nef protein delays the progression of CD4+ T cells through G1/S phase of the cell cycle.Determinants of increased replicative capacity of serially passaged simian immunodeficiency virus with nef deleted in rhesus monkeys.Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor.Dynamin 2 is required for the enhancement of HIV-1 infectivity by Nef.Characterization of nef sequences in long-term survivors of human immunodeficiency virus type 1 infection.Defective accessory genes in a human immunodeficiency virus type 1-infected long-term survivor lacking recoverable virusDetection of CD4+ T cells harboring human immunodeficiency virus type 1 DNA by flow cytometry using simultaneous immunophenotyping and PCR-driven in situ hybridization: evidence of epitope masking of the CD4 cell surface molecule in vivoNef stimulates human immunodeficiency virus type 1 proviral DNA synthesisInhibition of Nef- and phorbol ester-induced CD4 degradation by macrolide antibiotics.High frequency of defective nef alleles in a long-term survivor with nonprogressive human immunodeficiency virus type 1 infection.Nef association with human immunodeficiency virus type 1 virions and cleavage by the viral protease
P2860
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P2860
CD4 down-regulation by nef alleles isolated from human immunodeficiency virus type 1-infected individuals.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
1993年學術文章
@zh
1993年學術文章
@zh-hant
name
CD4 down-regulation by nef all ...... s type 1-infected individuals.
@ast
CD4 down-regulation by nef all ...... s type 1-infected individuals.
@en
type
label
CD4 down-regulation by nef all ...... s type 1-infected individuals.
@ast
CD4 down-regulation by nef all ...... s type 1-infected individuals.
@en
prefLabel
CD4 down-regulation by nef all ...... s type 1-infected individuals.
@ast
CD4 down-regulation by nef all ...... s type 1-infected individuals.
@en
P2860
P356
P1476
CD4 down-regulation by nef all ...... s type 1-infected individuals.
@en
P2093
Skowronski J
P2860
P304
P356
10.1073/PNAS.90.12.5549
P407
P577
1993-06-01T00:00:00Z