Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor.
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Multilayered mechanism of CD4 downregulation by HIV-1 Vpu involving distinct ER retention and ERAD targeting stepsStructural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1Assembly and architecture of biogenesis of lysosome-related organelles complex-1 (BLOC-1).Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complexLocalization to mature melanosomes by virtue of cytoplasmic dileucine motifs is required for human OCA2 functionStructural basis for recruitment and activation of the AP-1 clathrin adaptor complex by Arf1SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by NefHIV-1 Nef disrupts intracellular trafficking of major histocompatibility complex class I, CD4, CD8, and CD28 by distinct pathways that share common elementsHIV-1 Vpu targets cell surface markers CD4 and BST-2 through distinct mechanismsRemodeling of the Host Cell Plasma Membrane by HIV-1 Nef and Vpu: A Strategy to Ensure Viral Fitness and PersistenceForty Years of Clathrin-coated VesiclesThe clathrin adaptor complexes as a paradigm for membrane-associated allosteryHIV-1 Nef hijacks clathrin coats by stabilizing AP-1:Arf1 polygons.A structural explanation for the binding of endocytic dileucine motifs by the AP2 complexStructural basis of evasion of cellular adaptive immunity by HIV-1 NefHow HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4Structural and Functional Characterization of Cargo-Binding Sites on the μ4-Subunit of Adaptor Protein Complex 4Proteomic-based identification of CD4-interacting proteins in human primary macrophagesGolgi export of the Kir2.1 channel is driven by a trafficking signal located within its tertiary structureThe clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin β1 endocytosisModulation of HIV-1-host interaction: role of the Vpu accessory proteinFunctional characterization of protein-sorting machineries at the trans-Golgi network in Drosophila melanogasterHIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP-dependent pathway in T cells.The Epstein-Barr virus G-protein-coupled receptor contributes to immune evasion by targeting MHC class I molecules for degradationSIV Nef proteins recruit the AP-2 complex to antagonize Tetherin and facilitate virion release.Requirements of the membrane proximal tyrosine and dileucine-based sorting signals for efficient transport of the subtype C Vpu protein to the plasma membrane and in virus release.OrfA downregulates feline immunodeficiency virus primary receptor CD134 on the host cell surface and is important in viral infection.Conservation and diversification of dileucine signal recognition by adaptor protein (AP) complex variantsSelf-association of the Lentivirus protein, NefA cytoplasmic tail determinant in HIV-1 Vpu mediates targeting of tetherin for endosomal degradation and counteracts interferon-induced restriction.Interaction of HIV-1 Nef protein with the host protein Alix promotes lysosomal targeting of CD4 receptor.Cargo recognition in clathrin-mediated endocytosisHigh-affinity Dkk1 receptor Kremen1 is internalized by clathrin-mediated endocytosis.Tetherin/BST-2 antagonism by Nef depends on a direct physical interaction between Nef and tetherin, and on clathrin-mediated endocytosis.At the crossroads of homoeostasis and disease: roles of the PACS proteins in membrane traffic and apoptosis.Nef inhibits glucose uptake in adipocytes and contributes to insulin resistance in human immunodeficiency virus type I infection.Misdirection of membrane trafficking by HIV-1 Vpu and Nef: Keys to viral virulence and persistence.Protein trafficking dysfunctions: Role in the pathogenesis of pulmonary arterial hypertension.ADP ribosylation factor 1 activity is required to recruit AP-1 to the major histocompatibility complex class I (MHC-I) cytoplasmic tail and disrupt MHC-I trafficking in HIV-1-infected primary T cells.Drosophila as a genetic model for studying pathogenic human viruses
P2860
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P2860
Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Downregulation of CD4 by human ...... with the AP2 clathrin adaptor.
@ast
Downregulation of CD4 by human ...... with the AP2 clathrin adaptor.
@en
type
label
Downregulation of CD4 by human ...... with the AP2 clathrin adaptor.
@ast
Downregulation of CD4 by human ...... with the AP2 clathrin adaptor.
@en
prefLabel
Downregulation of CD4 by human ...... with the AP2 clathrin adaptor.
@ast
Downregulation of CD4 by human ...... with the AP2 clathrin adaptor.
@en
P2093
P2860
P356
P1433
P1476
Downregulation of CD4 by human ...... with the AP2 clathrin adaptor
@en
P2093
James H Hurley
O Wolf Lindwasser
Rittik Chaudhuri
William J Smith
P2860
P304
P356
10.1128/JVI.02725-06
P407
P577
2007-01-31T00:00:00Z